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Head and Neck Cancer

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Technical Basis of Radiation Therapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Technological advances in the field of radiation oncology have revolutionized the management of head and neck cancer over the last decade. As will be discussed, the transition toward more technologically sophisticated methods of radiation therapy (RT) planning and delivery has presented clinicians with unanswered questions requiring a search for new standards. Given the inherent complexity of many of the radiotherapeutic techniques currently used, a thorough understanding of the strengths and weaknesses of each is imperative so that the potential for disease cure can be maximized while keeping side effects to a minimum. Thus, the goal of this chapter is for the reader to gain an understanding of these technological issues and to develop an appreciation of the “art,” as well as the “science” of RT for head and neck cancer. In this chapter, the use of RT refers to external-beam techniques utilizing high-energy photons unless otherwise stated.

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References

  • Ang KK, Jiang Gl, Feng Y et al (2001) Extent and kinetics of recovery of occult spinal cord injury. Int J Radiat Oncol Biol Phys 50:1013–1020

    Article  PubMed  CAS  Google Scholar 

  • Barker JL, Garden AS, Ang KK et al (2004) Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system. Int J Radiat Oncol Biol Phys 59:960–970

    Article  PubMed  Google Scholar 

  • Bhandare N, Jackson A, Eisbruch A et al (2010) Radiation therapy and hearing loss. Int J Radiat Oncol Biol Phys 76:S50–S57

    Article  PubMed  Google Scholar 

  • Bhide S, Clark C, Harrington K et al (2007) Intensity modulated radiotherapy improves target coverage and parotid gland sparing when delivering total mucosal irradiation in patients with squamous cell carcinoma of head and neck of unknown primary site. Med Dosim 32:188–195

    Article  PubMed  Google Scholar 

  • Bhide S, Davies M, Burke K et al (2010) Weekly volume and dosimetric changes during chemoradiotherapy with intensity-modulated radiation therapy for head and neck cancer: a prospective observational study. Int J Radiat Oncol Biol Phys 76:1360–1368

    Article  PubMed  Google Scholar 

  • Bortfeld T (1997) An analytical approximation of the Bragg curve for therapeutic proton beams. Med Phys 24:2024–2033

    Article  PubMed  CAS  Google Scholar 

  • Braam PM, Roesink JM, Raaijmakers CP et al (2007) Quality of life and salivary output in patients with head-and-neck cancer five years after radiotherapy. Radiat Oncol 2:3

    Article  PubMed  Google Scholar 

  • Brown AP, Urie MM, Chisin R et al (1989) Proton therapy for carcinoma of the nasopharynx: a study in comparative treatment planning. Int J Radiat Oncol Biol Phys 16:1607–1614

    Article  PubMed  CAS  Google Scholar 

  • Chao KSC, Deasy JO, Markman J et al (2001a) A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results. Int J Radiat Oncol Biol Phys 49:907–916

    Article  PubMed  CAS  Google Scholar 

  • Chao KS, Majhail N, Huang CJ et al (2001b) Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol 61:275–280

    Article  PubMed  CAS  Google Scholar 

  • Chao KS, Bosch WR, Mutic S et al (2001c) A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 49:1171–1182

    Article  PubMed  CAS  Google Scholar 

  • Chao KS, Ozyigit G, Tran BN et al (2003) Patterns of failure in patients receiving definitive and postoperative IMRT for head and neck cancer. Int J Radiat Oncol Biol Phys 55:312–321

    Article  PubMed  Google Scholar 

  • Chen AM, Daly ME, Bucci MK et al (2007) Carcinomas of the paranasal sinuses and nasal cavity treated with radiotherapy at a single institution over five decades: are we making improvement? Int J Radiat Oncol Biol Phys 69:141–147

    Article  PubMed  Google Scholar 

  • Chen AM, Jennelle RLS, Sreeraman R et al (2009) Initial clinica experience with helical tomotherapy for head and neck cancer. Head Neck 31:1571–1578

    Article  PubMed  Google Scholar 

  • Chen AM, Farwell DG, Luu Q et al (2010) Misses and near-misses after postoperative radiation therapy for head and neck cancer: comparison of IMRT and non-IMRT techniques in the CT-simulation era. Head Neck 32:1452–1459

    Article  PubMed  Google Scholar 

  • Chen AM, Li BQ, Farwell DG et al (2011) Improved dosimetric and clinical outcomes with intensity-modulated radiotherapy for head-and-neck cancer of unknown primary origin. Int J Radiat Oncol Biol Phys 79:756–762

    Article  PubMed  Google Scholar 

  • Chera BS, Amdur RJ, Morris CG et al (2010) Carotid-sparing intensity-modulated radiotherapy for early-stage squamous cell carcinoma of the true vocal cord. Int J Radiat Oncol Biol Phys 77:1380–1385

    Article  PubMed  Google Scholar 

  • Choi W, Lee SW, Park SH et al (2010) Planning study for available dose of hypoxic tumor volume using fluorine-18-labeled fluoromisonidazole positron emission tomography for treatment of the head and neck cancer. Radiother Oncol 97:176–182

    Article  PubMed  Google Scholar 

  • DAHANCA, EORTC, GORTEC, NCIC and RTOG (2010) Endorsed consensus guidelines for the delineation of the CTV in the N0 neck of patients with head and neck squamous cell carcinoma. At: http://www.rtog.org/atlases/hnatlas/main.html. Accessed [December 1,]

  • Daly ME, Le QT, Jain AK et al (2011a) Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx. Head Neck 33:103–111

    Article  PubMed  Google Scholar 

  • Daly ME, Le QT, Jain AK et al (2011b) Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx. Head Neck 33:103–111

    Article  PubMed  Google Scholar 

  • Dawson LA, Myers LL, Bradford CR et al (2001) Conformal re-irradiation of recurrence and new primary head-and-neck cancer. Int J Radiat Oncol Biol Phys 50:377–385

    Article  PubMed  CAS  Google Scholar 

  • De Arruda FF, Puri DR, Zhung J et al (2006) Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: the memorial sloan-kettering cancer center experience. Int J Radiat Oncol Biol Phys 64:363–373

    Article  PubMed  Google Scholar 

  • De Braud F, Heilbrun LK, Ahmed K et al (1989) Metastatic squamous cell carcinoma of an unknown primary localized to the neck. Advantages of an aggressive treatment. Cancer 64:510–515

    Article  PubMed  Google Scholar 

  • De Crevoisier R, Domenge C, Wibault P et al (1998) Full-dose reirradiation for unresectable head and neck carcinoma: experience at the gustave-roussy institute in a series of 169 patients. J Clin Oncol 16:3556–3562

    PubMed  Google Scholar 

  • Deasy JO, Moiseenko C, Marks L et al (2010) Radiation dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys 76:S58–S63

    Article  PubMed  Google Scholar 

  • Den RB, Doemer A, Kubicek G et al (2010) Daily image guidance with cone-beam computed tomography for head and neck cancer intensity-modulated radiotherapy: a prospective study. Int J Radiat Oncol Biol Phys 76:1353–1359

    Article  PubMed  Google Scholar 

  • Dirix P, Nuyts S, Geussens Y et al (2007) Malignancies of the nasal cavity and paranasal sinuses: long-term outcome with conventional or three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 69:1042–1050

    Article  PubMed  Google Scholar 

  • Eisbruch A, Gregoire V (2009) Balancing risk and reward in target delineation for highly conformal radiotherapy in head and neck cancer. Semin Radiat Oncol 19:43–52

    Article  PubMed  Google Scholar 

  • Eisbruch A, Ten Haken RK, Kim HM et al (1999) Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys 45:577–587

    Article  PubMed  CAS  Google Scholar 

  • Eisbruch A, Marsh LH, Dawson LA et al (2004) Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing. Int J Radiat Oncol Biol Phys 59:28–42

    Article  PubMed  Google Scholar 

  • Eisbruch A, Harris J, Garden AS et al (2010) Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00–22). Int J Radiat Oncol Biol Phys 76:1333–1338

    Article  PubMed  Google Scholar 

  • El-Bassiouni M, Ciernik IF, Davis JB et al (2007) 18FDG] PET-CT-based intensity-modulated radiotherapy treatment planning of head and neck cancer. Int J Radiat Oncol Biol Phys 69:286–293

    Article  PubMed  Google Scholar 

  • Emami B, Bignardi M, Devineni VR et al (1987) Re-irradiation of recurrent head and neck cancers. Laryngscope 97:85–88

    CAS  Google Scholar 

  • Feng FY, Kim HM, Lyden TH et al (2007) Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 68:1289–1298

    Article  PubMed  Google Scholar 

  • Forastiere AA, Goepfert H, Maor M (2003) Concurrent chemotherapy and radiohterapy for organ preservasion in advanced laryngeal cancer. N Engl J Med 349:2091–2098

    Article  PubMed  CAS  Google Scholar 

  • Fossati P, Ricardi U, Orecchia R (2009) Pediatric medulloblastoma: toxicity of current treatment and potential role of proton therapy. Cancer Treat Rev 35:79–96

    Article  PubMed  CAS  Google Scholar 

  • Frank SJ, Rosenthal DI, Petsuksiri J et al (2010) Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M. D. Anderson cancer center outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 78:1005–1010

    Article  PubMed  Google Scholar 

  • Fujita M, Hirokawa Y, Kashiwado K (1999) Interstitial brachytherapy for stage I and II squamous cell carcinoma of the oral tongue: factors influencing local control and soft tissue complications. Int J Radiat Oncol Biol Phys 44:767–775

    Article  PubMed  CAS  Google Scholar 

  • Garden AS, Forster K, Wong PF et al (2003) Results of radiotherapy for T2N0 glottic carcinoma: does the “2” stand for twice-daily treatment? Int J Radiat Oncol Biol Phys 55:322–328

    Article  PubMed  Google Scholar 

  • Garden AS, Morrison WH, Wong PF et al (2007) Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 67:438–444

    Article  PubMed  Google Scholar 

  • Gomez D, Cahlon O, Mechalakos J et al (2010) An investigation of intensity-modulated radiation therapy versus conventional two-dimensional, 3D-conformal radiation therapy for early stage larynx cancer. Radiat Oncol 5:74

    Article  PubMed  Google Scholar 

  • Han C, Chen YJ, Liu A et al (2008) Actual dose variation of parotid glands and spinal cord for nasopharyngeal cancer patients during radiotherapy. Int J Radiat Oncol Biol Phys 70:1256–1262

    Article  PubMed  Google Scholar 

  • Hansen EK, Bucci MK, Quivey JM et al (2006) Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 64:355–362

    Article  PubMed  Google Scholar 

  • Hong TS, Tome WA, Chappell RJ et al (2005) The impact of daily setup variations on head-and-neck intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys 61:779–788

    Article  PubMed  Google Scholar 

  • Hosokawa Y, Shirato J, Nishioka T (2001) Effect of treatment time on outcome of radiotherapy for oral tongue carcinoma. Int J Radiat Oncol Biol Phys 57:71–78

    Article  Google Scholar 

  • Houghton F, Benson RJ, Tudor GS et al (2009) An assessment of action levels in imaging strategies in head and neck cancer using tomotherapy. Are our margins adequate in the absence of image guidance. Clin Oncol 21:720–727

    Article  CAS  Google Scholar 

  • Huang D, Xia P, Akazawa P et al (2003) Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys 56:158–168

    Article  PubMed  Google Scholar 

  • Huang K, Xia P, Chuang C et al (2008) Intensity-modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma: the University of california-san francisco experience. Cancer 113:497–507

    Article  PubMed  Google Scholar 

  • Humphreys M, Guerrero-Urbano MT, Mubata C et al (2005) Assessment of a customized immobilization system for head and neck IMRT using electronic portal imaging. Radiother Oncol 77:39–44

    Article  PubMed  Google Scholar 

  • ICRU Report 50 (1993) Prescribing, recording and reporting photon beam therapy. International Commission on Radiation Units and Measurements, Bethesda, MD

    Google Scholar 

  • IMRT Documentation Working Group, Holmes T, Das R, Low D et al (2009) American society of radiation oncology recommendations for documenting intensity-modulated radiation therapy treatments. Int J Radiat Oncol Biol Phys 74:1311–1318

    Article  PubMed  Google Scholar 

  • Islam MK, Purdie TG, Norrlinger BD et al (2006) Patient dose from kilovoltage cone beam computed tomography imaging in radiation therapy. Med Phys 33:1573–1582

    Article  PubMed  Google Scholar 

  • Jabbari S, Kim HM, Feng M et al (2008) Matched case-control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 70:1100–1107

    Article  Google Scholar 

  • Jensen K, Lambertsen K, Grau C (2007) Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters. Radiother Oncol 85:74–82

    Article  PubMed  Google Scholar 

  • Kan MW, Leung LH, Wong W et al (2008) Radiation dose from cone beam computed tomography for image-guided radiation therapy. Int J Radiat Oncol Biol Phys 70:272–279

    Article  PubMed  CAS  Google Scholar 

  • Kirkpatrick JP, Van der Kogel AJ, Schultheiss TE (2010) Radiation dose-volume effects in the spinal cord. Int J Radiat Oncol Biol Phys 76:S42–S49

    Article  PubMed  Google Scholar 

  • Langer CJ, Harris J, Horwitz EM et al (2007) Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of the radiation therapy oncology group protocol 9911. J Clin Oncol 25:4800–4805

    Article  PubMed  CAS  Google Scholar 

  • Langlois D, Eschwege F, Kramar A et al (1985) Re-irradiation of recurrent head and neck cancers. Radiother Oncol 3:27–33

    Article  PubMed  CAS  Google Scholar 

  • Lawrence YR, Li XA, el Naga I et al (2010) Radiation dose-volume effects in the brain. Int J Radiat Oncol Biol Phys 76:S20–S27

    Article  PubMed  Google Scholar 

  • Le QT, Fu KK, Kaplan M et al (2000) Lymph node metastasis in maxillary sinus carcinoma. Int J Radiat Oncol Biol Phys 46:541–549

    Article  PubMed  CAS  Google Scholar 

  • Lee N, Xia P, Fischbein NJ et al (2003) Intensity-modulated radiation therapy for head-and-neck cancer: the UCSF experience focusing on target volume delineation. Int J Radiat Oncol Biol Phys 57:49–60

    Article  PubMed  Google Scholar 

  • Lee N, Chan K, Bekelman JE et al (2007) Salvage re-irradiation for recurrent head and neck cancer. Int J Radiat Oncol Biol Phys 68:731–740

    Article  PubMed  Google Scholar 

  • Lee TK, Rosen II, Gibbons JP et al (2008a) Helical tomotherapy for parotid gland tumors. Int J Radiat Oncol Biol Phys 70:883–891

    Article  PubMed  Google Scholar 

  • Lee NY, Mechalakos JG, Nehmeh S et al (2008b) Fluorine-18-labeled fluoromisonidazole positron emission and computed tomography-guided intensity-modulated radiotherapy for head and neck cancer: a feasibility study. Int J Radiat Oncol Biol Phys 70:2–13

    Article  PubMed  CAS  Google Scholar 

  • Lee C, Langen KM, Lu W et al (2008c) Assesment of parotid gland dose changes during head and neck cancer radiotherapy using daily megavoltage computed tomography and deformable image registration. Int J Radiat Oncol Biol Phys 71:1563–1571

    Article  PubMed  Google Scholar 

  • Lee N, Harris J, Garden AS et al (2009) Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 27:3684–3690

    Article  PubMed  Google Scholar 

  • Lehmann J, Perks J, Sermon S et al (2007) Commissioning experience with cone-beam computed tomography for image-guided radiation therapy. J Appl Clin Med Phys 8:21–36

    Article  Google Scholar 

  • Levendag P, Braaksma M, Coche E et al (2004) Rotterdam and brussels CT-based neck nodal delineation compared with the surgical levels as defined by the American academy of otolaryngology-head and neck surgery. Int J Radiat Oncol Biol Phys 58:113–123

    Article  PubMed  Google Scholar 

  • Levendag PC, Teguh DN, Voet P et al (2007) Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship. Radiother Oncol 85:64–73

    Article  PubMed  Google Scholar 

  • Li H, Zhu RX, Zhang L et al (2008) Comparison of 2D radiographic images and 3D cone beam computed tomography for positioning head-and-neck radiotherapy patients. Int J Radiat Oncol Biol Phys 71:916–925

    Article  PubMed  Google Scholar 

  • Logue JP, Sharrock CL, Cowan RA et al (1998) Clinical variability of target volume description in conformal radiotherapy planning. Int J Radiat Oncol Biol Phys 41:929–931

    Article  PubMed  CAS  Google Scholar 

  • Lu H, Yao M, Tan H (2009) Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: to what extent the volume should be irradiated. Oral Oncol 45:474–479

    Article  PubMed  Google Scholar 

  • Madani I, Duthoy W, Derie C et al (2007) Positron emission tomography-guided, focal-dose escalation using intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 68:126–135

    Article  PubMed  Google Scholar 

  • Mayo C, Martel MK, Marks LB et al (2010a) Radiation dose–volume effects of optic nerves and chiasm. Int J Radiat Oncol Biol Phys 76:S28–S35

    Article  PubMed  Google Scholar 

  • Mayo C, Yorke E, Merchant TE (2010b) Radiation associated brainstem injury. Int J Radiat Oncol Biol Phys 76:S36–S41

    Article  PubMed  Google Scholar 

  • Mechalakos J, Lee N, Hunt M et al (2009) The effect of significant tumor reduction on the dose distribution in intensity modulated radiation therapy for head-and-neck cancer: a case study. Med Dosim 34:250–255

    Article  PubMed  Google Scholar 

  • Meeks SL, Harmon JF, Langen KM et al (2005) Performance characterization of megavoltage computed tomography imaging on a helical tomotherapy unit. Med Phys 32:2673–2681

    Article  PubMed  Google Scholar 

  • Mendenhall WM, Mendenhall CM, Malyapa RS et al (2008) Re-irradiation of head and neck carcinoma. Am J Clin Oncol 31:393–398

    Article  PubMed  Google Scholar 

  • Miah A, Scott-Brown M, Harrington K et al (2010) Evidence-based review: quality of life following head and neck intensity-modulated radiotherapy. Radiother Oncol 97:249–257

    Article  PubMed  Google Scholar 

  • Miralbell R, Crowell C, Suit HD (1992) Potential improvement of three dimension treatment planning and proton therapy in the outcome of maxillary sinus cancer. Int J Radiat Oncol Biol Phys 22:305–310

    Article  PubMed  CAS  Google Scholar 

  • Mock U, Georg D, Bogner J et al (2004) Treatment planning comparison of conventional, 3D conformal, and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys 58:147–154

    Article  PubMed  Google Scholar 

  • Mohan R, Zhang X, Wang H et al (2005) Use of deformed intensity distributions for on-line modification of image-guided IMRT to account for interfractional anatomic changes. Int J Radiat Oncol Biol Phys 61:1258–1266

    Article  PubMed  Google Scholar 

  • Montejo ME, Shrieve DC, Bentz BG, et al. (2010) IMRT with simultaneous integrated boost and concurrent chemotherapy for locoregionally advanced squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. Dec 16. (Epub ahead of print)

    Google Scholar 

  • Nieder C, Milas L, Ang KK (2000) Tissue tolerance to reirradiation. Sem Radiat Oncol 10:200–209

    Article  CAS  Google Scholar 

  • Nieder C, Gregoire V, Ang KK (2001) Cervical lymph node metastasis from occult squamous cell carcinoma: cut down a tree to get an apple? Int J Radiat Oncol Biol Phys 50:727–733

    Article  PubMed  CAS  Google Scholar 

  • Nithiananthan S, Brock KK, Daly MJ et al (2009) Demons deformable registration for CBCT-guided procedures in the head and neck: convergence and accuracy. Med Phys 36:4755–4764

    Article  PubMed  CAS  Google Scholar 

  • Nutting CM, Morden JP, Harrington KJ et al (2011) Parotid-sparing intensity-modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomized controlled trial. Lancet Oncol 12:127–136

    Article  PubMed  Google Scholar 

  • O’daniel JC, Garden AS, Schwartz DL et al (2007) Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get? Int J Radiat Oncol Biol Phys 69:1290–1296

    Article  PubMed  Google Scholar 

  • O’sullivan B, Warde P, Grice B et al (2001) The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region. Int J Radiat Oncol Biol Phys 51:332–343

    Article  PubMed  Google Scholar 

  • Palazzi M, Fossa-Jereczeck BA, Soatti C (2004) CT-based delineation of lymph node levels in the neck: can we optimize the consensus? Radiother Oncol 73:383–386

    Article  PubMed  Google Scholar 

  • Pfister DG, Laurie SA, Weinstein GS et al (2006) American society of clinical oncology clinical practice guideline for the use of laryn-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 24:3693–3704

    Article  PubMed  Google Scholar 

  • Poon I, Fischbein N, Lee N et al (2004) A population-based atlas and clinical target volume for the head and neck lymph nodes. Int J Radiat Oncol Biol Phys 59:1301–1311

    Article  PubMed  Google Scholar 

  • Rancati T, Schwarz M, Allen AM et al (2010) Radiation dose-volume effects in the larynx and pharynx. Int J Radiat Oncol Biol Phys 76:S64–S69

    Article  PubMed  Google Scholar 

  • Rosenthal DI, Fuller CD, Barker JL Jr et al (2010) Simple carotid-sparing intensity-modulated radiotherapy technique and preliminary experience for T1–2 glottic cancer. Int J Radiat Oncol Biol Phys 77:455–461

    Article  PubMed  Google Scholar 

  • Salama JK, Vokes EE, Chmura SJ et al (2006) Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 64:382–391

    Article  PubMed  Google Scholar 

  • Schoenfeld JD, Sher DJ, Norris CM Jr, et al. (2010) Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy. Int J Radiat Oncol Biol Phys

    Google Scholar 

  • Schubert LK, Westerly DC, Tome WA et al (2009) A comprehensive assessment of tumor site of patient setup using daily MVCT imaging from more than 3,800 helical tomotherapy treatments. Int J Radiat Oncol Biol Phys 73:1260–1269

    Article  PubMed  Google Scholar 

  • Spencer SA, Harris J, Wheeler RH et al (2008) Final report of RTOG 96–10, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head Neck 30:281–288

    Article  PubMed  Google Scholar 

  • Stapleford LJ, Lawson JD, Perkins C et al (2010) Evaluation of automatic atlas-based lymph node segmentation for head-and-neck cancer. Int J Radiat Oncol Biol Phys 77:959–966

    Article  PubMed  Google Scholar 

  • Steneker M, Lomax A, Schneider U (2006) Intensity modulated photon and proton therapy for the treatment of head and neck tumors. Radiother Oncol 80:263–267

    Article  PubMed  CAS  Google Scholar 

  • Stroom JC, Heijmen BJ (2002) Geometrical uncertainties, radiotherapy planning margins, and the ICRU-62 report. Radiother Oncol 64:75–83

    Article  PubMed  Google Scholar 

  • Studer G, Furrer K, Davis BJ et al (2006) Postoperative IMRT in head and neck cancer. Radiat Oncol 1:40

    Article  PubMed  Google Scholar 

  • Sulman EP, Schwartz DL, Le TT et al (2009) IMRT reirradiation of head and neck cancer- disease control and morbidity outcomes. Int J Radiat Oncol Biol Phys 73:399–409

    Article  PubMed  Google Scholar 

  • Sykes JR, Amer A, Czajka J et al (2005) A feasibility study for image guided radiotherapy using low dose, high speed, cone beam X-ray volumetric imaging. Radiother Oncol 77:45–52

    Article  PubMed  Google Scholar 

  • The Department of Veterans Affairs Laryngeal Cancer Study Group (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 324:1685–1690

    Article  Google Scholar 

  • Tsien C, Eisbruch A, McShan D et al (2003) Intensity-modulated radiation therapy for locally advanced paranasal sinus tumors: incorporating clinical decisions in the optimization process. Int J Radiat Oncol Biol Phys 55:776–784

    Article  PubMed  Google Scholar 

  • van Asselen B, Dehnad H, Raaijmakers CP et al (2002) The dose to the parotid glands with IMRT for oropharyngeal tumors: the effect of reduction of positioning margins. Radiother Oncol 64:197–204

    Article  PubMed  Google Scholar 

  • van Herk M (2004) Errors and margins in radiotherapy. Semin Radiat Oncol 14:52–64

    Article  PubMed  Google Scholar 

  • Voet PW, Dirkx ML, Teguh DN et al (2011) Does atlas-based autosegmentation of neck levels require subsequent manual contour editing to avoid risk of severe target underdosage? A dosimetric analysis. Radiother Oncol 98:373–377

    Article  PubMed  Google Scholar 

  • Wang CC, Biggs PJ (1992) Technical and radiotherapeutic considerations of intra-oral cone electron beam radiation therapy for head and neck cancer. Semin Radiat Oncol 2:171–179

    Article  PubMed  Google Scholar 

  • Wang CC, Doppke KP, Biggs PJ (1983) Intra-oral cone radiation therapy for selected carcinomas of the oral cavity. Int J Radiat Oncol Biol Phys 9:1185–1189

    Article  PubMed  CAS  Google Scholar 

  • Wang D, Schultz CJ, Jursinic PA et al (2006) Initial experience of FDG-PET/CT guided IMRT of head-and-neck carcinoma. Int J Radiat Oncol Biol Phys 65:143–151

    Article  PubMed  Google Scholar 

  • Wijers OB, Levendag PC, Tan T et al (1999) A simplified CT-based definition of the lymph node levels in the node negative neck. Radiother Oncol 52:35–42

    Article  PubMed  CAS  Google Scholar 

  • Wu Q, Mohan R, Morris M et al (2003) Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results. Int J Radiat Oncol Biol Phys 56:573–585

    Article  PubMed  Google Scholar 

  • Wu Q, Chi Y, Chen PY et al (2009) Adaptive replanning strategies accounting for shrinkage in head and neck IMRT. Int J Radiat Oncol Biol Phys 75:924–932

    Article  PubMed  Google Scholar 

  • Yan D, Wong J, Vicini F et al (1997) Adaptive modification of treatment planning to minimize the deleterious effects of treatment setup errors. Int J Radiat Oncol Biol Phys 38:197–206

    Article  PubMed  CAS  Google Scholar 

  • Yao M, Dornfeld KJ, Buatti JM et al (2005) Intensity-modulated radiation treatment for head-and-neck squamous cell carcinoma—the University of Iowa experience. Int J Radiat Oncol Biol Phys 63:410–421

    Article  PubMed  Google Scholar 

  • Yu Y, Michaud AL, Sreeraman R et al (2010) Potential utility of image-guidance to reduce PTV margins for patients treated by IMRT for head, neck cancer: evaluation of temporal-based protocols. Int J Radiat Oncol Biol Phys 78:105S

    Article  Google Scholar 

  • Zeidan OA, Langen KM, Meeks SL et al (2007) Evaluation of image-guidance protocols in the treatment of head and neck cancers. Int J Radiat Oncol Biol Phys 67:670–677

    Article  PubMed  Google Scholar 

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Correspondence to Allen M. Chen .

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© 2011 Springer-Verlag Berlin Heidelberg

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Chen, A.M., Clifford Chao, K.S. (2011). Head and Neck Cancer. In: Levitt, S., Purdy, J., Perez, C., Poortmans, P. (eds) Technical Basis of Radiation Therapy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_353

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  • DOI: https://doi.org/10.1007/174_2011_353

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