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Technical Basis of Radiation Therapy pp 565–599Cite as

Central Nervous System Tumors

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Tumors of the central nervous system account for a substantial amount of morbidity and mortality annually. Radiation therapy (RT) has played an increasingly larger role in the treatment of CNS tumors as technology has advanced and radiation delivery has become more accurate and conformal. In the modern era of radiation therapy normal structures can be delineated and avoided with extreme precision and accuracy, maximizing the delivery of RT to the tumor and minimizing the RT to normal structures. For patients with tumors not amenable to surgical resection radiotherapy often plays a definitive role in the management of these malignancies. Additionally the ability of radiotherapy to control brain tumors is increasing in the era of modern day chemotherapy which can frequently be used to increase the sensitivity of various malignancies to radiotherapy. As RT technology advances the role of RT in the management of CNS malignancies will likely continue to increase over the coming years. The future of radiation delivery in the CNS is exciting and rapidly changing. The following chapter servers as a general overview to the management and treatment of a variety of CNS tumors, and presents some exciting advances in radiation therapy that may play a larger role in the future.

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References

  • Ali I, Tubbs J, Hibbitts K et al (2010) Evaluation of the setup accuracy of a stereotactic radiotherapy head immobilization mask system using kV on-board imaging. J Appl Clin Med Phys 11:3192

    PubMed  Google Scholar 

  • Amdur RJ, Bennett J, Olivier K et al (2009) A prospective, phase II study demonstrating the potential value and limitation of radiosurgery for spine metastases. Am J Clin Oncol

    Google Scholar 

  • American Cancer Society (2005) Cancer facts and figures 2005. American Cancer Society, Atlanta

    Google Scholar 

  • Andrews DW, Scott CB, Sperduto PW (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672

    Article  PubMed  Google Scholar 

  • Aoyama H, Shirato H, Tago M, Nakagawa K et al (2006) Stereotactic radiosurgery plus whole brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295(21):2483–2491

    Article  PubMed  CAS  Google Scholar 

  • Babiloni F, Mattia D, Babiloni C et al (2004) Multimodal integration of EEG, MEG and fMRI data for the solution of the neuroimage puzzle. Magn Reson Imaging 22:1471–1476

    Article  PubMed  Google Scholar 

  • Balter JM et al (2005) Accuracy of a wireless localization system for radiotherapy. Int J Radiat Oncol Biol Phys 61:933–937

    Article  PubMed  Google Scholar 

  • Barnes D, Egan G, O’Keefe G et al (1997) Characterization of dynamic 3-D PET imaging for functional brain mapping. IEEE Trans Med Imaging 16:261–269

    Article  PubMed  CAS  Google Scholar 

  • Barnett GH et al (2007) Stereotactic radiosurgery: an organized neurosurgery-sanctioned definition. J Neurosurg 106:1–5

    Article  PubMed  Google Scholar 

  • Barnholtz-Sloan JS, Sloan AE, Davis FG et al (2004) Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol 22:2865–2872

    Article  PubMed  Google Scholar 

  • Bell BA, Smith MA, Kean DM et al (1987) Brain water measured by magnetic resonance imaging. Correlation with direct estimation and changes after mannitol and dexamethasone. Lancet 1:66–69

    Article  PubMed  CAS  Google Scholar 

  • Bilsky M, Posner JB (1993) Intensive and postoperative care of intracranial tumors. In: Ropper AH (ed) Neurological and neurosurgical intensive care. Raven Press, New York, pp 309–329

    Google Scholar 

  • Bilsky MH, Lis E, Raizer J et al (1999) The diagnosis and treatment of metastatic spinal tumor. Oncologist 4:459–469

    PubMed  CAS  Google Scholar 

  • Blomgren H et al (1995) Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol 34:861–870

    Article  PubMed  CAS  Google Scholar 

  • Breneman JC, Steinmetz R, Smith A et al (2009) Frameless image-guided intracranial stereotactic radiosurgery: clinical outcomes for brain metastases. Int J Radiat Oncol Biol Phys 74:702–706

    Article  PubMed  Google Scholar 

  • Brodmann K (1908a) Beiträge zur histologischen Lokalisation der Grosshirnrinde. VI. Die Cortexgliederung des Menschen. J Psychol Neurol 10:287–334

    Google Scholar 

  • Brodmann K (1908b) Beiträge zur histologischen Lokalisation der Grosshirnrinde. VI. Die Cortexgliederung des Menschen. J Psychol Neurol 10:231–246

    Google Scholar 

  • Brown PD, Buckner JC, O’Fallon JR et al (2004) Adult patients with supratentorial pilocytic astrocytomas: a prospective multicenter clinical trial. Int J Radiat Oncol Biol Phys 58:1153–1160

    Article  PubMed  Google Scholar 

  • Byrne TN (1992) Spinal cord compression from epidural metastases. N Engl J Med 327:614–619

    Article  PubMed  CAS  Google Scholar 

  • CBTRUS (2004) Statistical report: primary brain tumors in the United States, 1997–2001 years data collected. Central brain tumor registry United States

    Google Scholar 

  • Chang EL, Yi W, Allen PK et al (2003) Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys 56:519–528

    Article  PubMed  Google Scholar 

  • Chang EL, Shiu AS, Mendel E et al (2007) Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine 7(2):151–160

    Article  PubMed  Google Scholar 

  • Chang EL et al (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10:1037–1044

    Article  PubMed  Google Scholar 

  • Chen JC, Bugoci DM, Girvigian MR et al (2009) Control of brain metastases using frameless image-guided radiosurgery. Neurosurg Focus 27:E6

    Article  PubMed  Google Scholar 

  • Choi SJ, Kim JS, Kim JH et al (2005) [(18)F]3′-deoxy-3′-fluorothymidine PET for the diagnosis and grading of brain tumors. Eur J Nucl Med Mol Imaging (in press)

    Google Scholar 

  • Choi CY, Adler JR, Gibbs IC et al (2010) Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord. Int J Radiat Oncol Biol Phys 78(2):499–506

    Article  PubMed  Google Scholar 

  • Condra KS, Buatti JM, Mendenhall WM et al (1997) Benign meningiomas: primary treatment selection affects survival. Int J Radiat Oncol Biol Phys 39:427–436

    Article  PubMed  CAS  Google Scholar 

  • Connolly ES (1982) Spinal cord tumors in adults. In: Winn RH (ed) Youmans’ neurological surgery. Saunders, Philadelphia, p 3196

    Google Scholar 

  • Daumas-Duport C, Scheithauer B, O’Fallon J et al (1988) Grading of astrocytomas. A simple and reproducible method. Cancer 62:2152–2165

    Article  PubMed  CAS  Google Scholar 

  • Degen JW, Gagnon GJ, Voyadzis JM et al (2005) CyberKnife stereotactic radiosurgical treatment of spinal tumors for pain control and quality of life. J Neurosurg Spine 2(5):540–549

    Article  PubMed  Google Scholar 

  • Deye J, Abrams J, Coleman N (2005) The National Cancer Institute Guidelines for the use of intensity-modulated radiation therapy in clinical trials. DCTD, NCI. 1-14-2005. http://www3.cancer.gov/rrp/imrt2004.pdf

  • Di Salle F et al (2003) High field functional MRI. Eur J Radiol 48:138–145

    Article  PubMed  CAS  Google Scholar 

  • Emami B, Lyman J, Brown A et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21:109–122

    Article  PubMed  CAS  Google Scholar 

  • Epilepsy Foundation of America (1993) Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America’s Working Group on Status Epilepticus. JAMA 270:854–859

    Article  Google Scholar 

  • Ferlay J, Bray F, Pisani P, Parkin DM (2001) GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide, version 1.0. IARC CancerBase 5. IARC, Lyon

    Google Scholar 

  • Forsyth PA, Weaver S, Fulton D et al (2003) Prophylactic anticonvulsants in patients with brain tumour. Can J Neurol Sci 30:106–112

    PubMed  Google Scholar 

  • French L (1966) The use of steroids in the treatment of cerebral edema. Bull NY Acad Med 42:301–311

    CAS  Google Scholar 

  • Gaspar L, Scott C, Rotman M et al (1997) Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37:745–751

    Article  PubMed  CAS  Google Scholar 

  • Gaspar L, Scott C, Murray K et al (2000) Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases. Int J Radiat Oncol Biol Phys 47:1001–1006

    Article  PubMed  CAS  Google Scholar 

  • Gerszten PC, Welch WC (2000) Current surgical management of metastatic spinal disease. Oncology (Huntingt) 14:1013–1024

    CAS  Google Scholar 

  • Gerszten PC, Burton SA, Welch WC (2005) Single-fraction radiosurgery for the treatment of spinal breast metastases. Cancer 104:2244–2254

    Article  PubMed  Google Scholar 

  • Gerszten PC, Burton SA, Belani CP (2006) Radiosurgery for the treatment of spinal lung metastases. Cancer 107:2653–2661

    Article  PubMed  Google Scholar 

  • Gerszten PC, Burton SA, Ozhasoglu C, Welch WC (2007) Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine (Phila Pa 1976) 32(2):193–199

    Article  Google Scholar 

  • Gibbs IC, Kamnerdsupaphon P, Ryu MR et al (2007) Image-guided robotic radiosurgery for spinal metastases. Radiother Oncol 82(2):185–190

    Article  PubMed  Google Scholar 

  • Gilbert RW, Kim JH, Posner JB (1978) Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3:40–51

    Article  PubMed  CAS  Google Scholar 

  • Glantz MJ, Cole BF, Friedberg MH et al (1996) A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors. Neurology 46:985–991

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith BJ, Wara WM, Wilson CB et al (1994) Postoperative irradiation for subtotally resected meningiomas. A retrospective analysis of 140 patients treated from 1967 to 1990. J Neurosurg 80:195–201

    Article  PubMed  CAS  Google Scholar 

  • Greenberg HS, Kim JH, Posner JB (1980) Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neurol 8:361–366

    Article  PubMed  CAS  Google Scholar 

  • Gripp S, Kambergs J, Wittkamp M et al (2004) Coverage of anterior fossa in whole-brain irradiation. Int J Radiat Oncol Biol Phys 59:515–520

    Article  PubMed  Google Scholar 

  • Hahn CA et al (2009) Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction. Int J Radiat Oncol Biol Phys 73:1082–1087

    Article  PubMed  CAS  Google Scholar 

  • Hamilton AJ et al (1996) LINAC-based spinal stereotactic radiosurgery. Stereotact Funct Neurosurg 66:1–9

    Article  PubMed  CAS  Google Scholar 

  • Hazuka MB, Burleson WD, Stroud DN et al (1993) Multiple brain metastases are associated with poor survival in patients treated with surgery and radiotherapy. J Clin Oncol 11:369–373

    PubMed  CAS  Google Scholar 

  • Healey JH, Brown HK (2000) Complications of bone metastases: surgical management. Cancer 88:2940–2951

    Article  PubMed  CAS  Google Scholar 

  • Heimdal K, Hirschberg H, Slettebo H et al (1992) High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression. J Neurooncol 12:141–144

    Article  PubMed  CAS  Google Scholar 

  • Helweg-Larsen S, Sorensen PS, Kreiner S (2000) Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients. Int J Radiat Oncol Biol Phys 46:1163–1169

    Article  PubMed  CAS  Google Scholar 

  • Hochberg FH, Pruitt A (1980) Assumptions in the radiotherapy of glioblastoma. Neurology 30:907–911

    Article  PubMed  CAS  Google Scholar 

  • Hong LX, Chen CC, Garg M et al (2009) Clinical experiences with onboard imager KV images for linear accelerator-based stereotactic radiosurgery and radiotherapy setup. Int J Radiat Oncol Biol Phys 73:556–561

    Article  PubMed  Google Scholar 

  • Hoskin PJ, Grover A, Bhana R (2003) Metastatic spinal cord compression: radiotherapy outcome and dose fractionation. Radiother Oncol 68:175–180

    Article  PubMed  Google Scholar 

  • Huntington HW, Kernohan JW, Stapley LA (1965) Tumors of the central nervous system. Ariz Med 22:683–686

    PubMed  CAS  Google Scholar 

  • Husband DJ, Grant KA, Romaniuk CS (2001) MRI in the diagnosis and treatment of suspected malignant spinal cord compression. Br J Radiol 74:15–23

    PubMed  CAS  Google Scholar 

  • International Agency for Research on Cancer (2000) World Health Organization classification of tumours: pathology and genetics. Tumours of the nervous system, 2nd edn. Oxford Univ Press, Lyon

    Google Scholar 

  • International Commission on Radiation Units and Measurements I (1993) ICRU report 50, prescribing, recording, and reporting photon beam therapy. Nuclear Technology Publishing, Bethesda

    Google Scholar 

  • International Commission on Radiation Units and Measurements I (1999) ICRU report 62: prescribing, recording and reporting photon beam therapy (supplement to ICRU report 50). Nuclear Technology Publishing, Bethesda

    Google Scholar 

  • Jankovic M, Brouwers P, Valsecchi MG, Van Veldhuizen A, Huisman J, Kamphuis R et al (1994) Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. ISPACC. International Study Group on Psychosocial Aspects of Childhood Cancer. Lancet 344:224–227

    Article  PubMed  CAS  Google Scholar 

  • Jasper KR, Hummel SM, Laramore GE (2004) 3D naming system. Med Dosim 29:97–103

    Article  PubMed  Google Scholar 

  • Kalkanis SN, Eskandar EN, Carter BS et al (2003) Microvascular decompression surgery in the United States, 1996 to 2000: mortality rates, morbidity rates, and the effects of hospital and surgeon volumes. Neurosurgery 52:1251–1261

    Article  PubMed  Google Scholar 

  • Karim AB, Maat B, Hatlevoll R et al (1996) A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844. Int J Radiat Oncol Biol Phys 36:549–556

    Article  PubMed  CAS  Google Scholar 

  • Karim AB, Afra D, Cornu P et al (2002) Randomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BRO4: an interim analysis. Int J Radiat Oncol Biol Phys 52:316–324

    Article  PubMed  Google Scholar 

  • Kaser-Hotz B, Sumova A, Lomax A et al (2002) A comparison of normal tissue complication probability of brain for proton and photon therapy of canine nasal tumors. Vet Radiol Ultrasound 43:480–486

    Article  PubMed  Google Scholar 

  • Kirsch DG, Tarbell NJ (2004) Conformal radiation therapy for childhood CNS tumors. Oncologist 9:442–450

    Article  PubMed  Google Scholar 

  • Kovacs A, Toth L, Glavak C (2010) Integrating functional MRI information into radiotherapy planning of CNS tumors-early experiences. Pathol Oncol Res

    Google Scholar 

  • Liang BC, Thornton AF Jr, Sandler HM, Greenberg HS (1991) Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapy. J Neurosurg 75:559–563

    Article  PubMed  CAS  Google Scholar 

  • Liu BL, Cheng JX, Zhang X, Zhang W (2010) Controversies concerning the application of brachytherapy in central nervous system tumors. J Cancer Res Clin Oncol 136:173–185

    Article  PubMed  Google Scholar 

  • Loblaw DA, Laperriere NJ (1998) Emergency treatment of malignant extradural spinal cord compression: an evidence-based guideline. J Clin Oncol 16:1613–1624

    PubMed  CAS  Google Scholar 

  • Loblaw DA, Laperriere NJ, Mackillop WJ (2003) A population-based study of malignant spinal cord compression in Ontario. Clin Oncol (R Coll Radiol) 15:211–217

    Article  CAS  Google Scholar 

  • Long DM, Hartmann JF, French LA (1966) The response of experimental cerebral edema to glucosteroid administration. J Neurosurg 24:843–854

    Article  PubMed  CAS  Google Scholar 

  • Louis DN et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109

    Article  PubMed  Google Scholar 

  • Marcus RB Jr, Million RR (1990) The incidence of myelitis after irradiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 19:3–8

    Article  PubMed  Google Scholar 

  • Marsh JC, Gielda BT, Herskovic AM, Abrams RA (2010) Cognitive sparing during the administration of whole brain radiotherapy and prophylactic cranial irradiation: current concepts and approaches. J Oncol 2010:198208

    Article  PubMed  Google Scholar 

  • Maranzano E, Latini P (1995) Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial. Int J Radiat Oncol Biol Phys 32:959–967

    Article  PubMed  CAS  Google Scholar 

  • Maranzano E, Latini P, Checcaglini F et al (1992) Radiation therapy of spinal cord compression caused by breast cancer: report of a prospective trial. Int J Radiat Oncol Biol Phys 24:301–306

    Article  PubMed  CAS  Google Scholar 

  • Maranzano E, Latini P, Beneventi S et al (1996) Radiotherapy without steroids in selected metastatic spinal cord compression patients. A phase II trial. Am J Clin Oncol 19:179–183

    Article  PubMed  CAS  Google Scholar 

  • Maranzano E, Latini P, Perrucci E et al (1997) Short-course radiotherapy (8 Gy × 2) in metastatic spinal cord compression: an effective and feasible treatment. Int J Radiat Oncol Biol Phys 38:1037–1044

    Article  PubMed  CAS  Google Scholar 

  • Maranzano E, Frattegiani A, Rossi R, Bagnoli R, Mignogna M, Bellavista R, Perrucci E, Lupattelli M, Ponticelli P, Latini P (2002) Randomized trial of two different hypofractionated radiotherapy (RT) schedules (8 Gy × 2 vs 5 Gy × 3; 3 Gy × 5) in metastatic spinal cord compression (MSCC) [abstract]. Radiother Oncol 64:82–83

    Google Scholar 

  • McAleese JJ, Stenning SP, Ashley S et al (2003) Hypofractionated radiotherapy for poor prognosis malignant glioma: matched pair survival analysis with MRC controls. Radiother Oncol 67:177–182

    Article  PubMed  CAS  Google Scholar 

  • McDonald MW, Shu HK, Curran WJ Jr, Crocker IR (2011) Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma. Int J Radiat Oncol Biol Phys 79:130–136

    Article  PubMed  CAS  Google Scholar 

  • McKnight TR, dem Bussche MH, Vigneron DB et al (2002) Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. J Neurosurg 97:794–802

    Article  PubMed  Google Scholar 

  • Michalski JM (1998) Spinal canal. In: Leibel SA, Phillips TL (eds) Textbook of radiation oncology. Saunders, Philadelphia, pp 860–875

    Google Scholar 

  • Michalski J, Purdy JA, Gaspar L et al (2001) Radiation Therapy Oncology Group. Research Plan 2002–2006. Image-Guided Radiation Therapy Committee. Int J Radiat Oncol Biol Phys 51:60–65

    Article  PubMed  CAS  Google Scholar 

  • Miller AD, Leslie RA (1994) The area postrema and vomiting. Frontiers Neuroendocrinol 15:301–320

    Article  CAS  Google Scholar 

  • Minehan KJ, Shaw EG, Scheithauer BW et al (1995) Spinal cord astrocytoma: pathological and treatment considerations. J Neurosurg 83:590–595

    Article  PubMed  CAS  Google Scholar 

  • Mintz AH, Kestle J, Rathbone MP et al (1996) A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 78:1470–1476

    Article  PubMed  CAS  Google Scholar 

  • Munley MT, Kearns WT, Hinson WH et al (2002) Bioanatomic IMRT treatment planning with dose function histograms. Int J Radiat Oncol Biol Phys 54:126

    Article  Google Scholar 

  • Nelson JW, Yoo DS, Sampson JH et al (2009) Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. Int J Radiat Oncol Biol Phys 73(5):1369-1375

    Article  PubMed  Google Scholar 

  • Nuutinen J, Sonninen P, Lehikoinen P et al (2000) Radiotherapy treatment planning and long-term follow-up with [C-11]methionine pet in patients with low-grade astrocytoma. Int J Radiat Oncol Biol Phys 48:43–52

    Article  PubMed  CAS  Google Scholar 

  • Ogawa S et al (1990) Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 1:1

    Google Scholar 

  • O’Rourke T, George CB, Redmond J III et al (1986) Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease. J Clin Oncol 4:576–583

    PubMed  Google Scholar 

  • Patchell RA (2003) The management of brain metastases. Cancer Treat Rev 29:533–540

    Article  PubMed  Google Scholar 

  • Patchell RA, Tibbs PA, Walsh JW et al (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500

    Article  PubMed  CAS  Google Scholar 

  • Patchell RA, Tibbs PA, Regine WF et al (1998) Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 280(17):1485–1489

    Article  PubMed  CAS  Google Scholar 

  • Patchell RA, Tibbs PA, Regine WF et al (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366:643–648

    Article  PubMed  Google Scholar 

  • Percy AK, Elveback LR, Okazaki H et al (1972) Neoplasms of the central nervous system. Epidemiologic considerations. Neurology 22:40–48

    Article  PubMed  CAS  Google Scholar 

  • Perry A, Scheithauer BW, Stafford SL et al (1999) “Malignancy” in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer 85:2046–2056

    PubMed  CAS  Google Scholar 

  • Phillips C, Guiney M, Smith J et al (2003) A randomized trial comparing 35 Gy in ten fractions with 60 Gy in 30 fractions of cerebral irradiation for glioblastoma multiforme and older patients with anaplastic astrocytoma. Radiother Oncol 68:23–26

    Article  PubMed  Google Scholar 

  • Pigott KH, Baddeley H, Maher EJ (1994) Pattern of disease in spinal cord compression on MRI scan and implications for treatment. Clin Oncol (R Coll Radiol) 6:7–10

    Article  CAS  Google Scholar 

  • Pirzkall A, Larson DA, McKnight TR et al (2000) MR-Spectroscopy results in improved target delineation for high-grade gliomas. Int J Radiat Oncol Biol Phys 48:115

    Article  Google Scholar 

  • Prados MD, Seiferheld W, Sandler HM et al (2004) Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404. Int J Radiat Oncol Biol Phys 58:1147–1152

    Article  PubMed  CAS  Google Scholar 

  • Preston-Martin S (1990) Descriptive epidemiology of primary tumors of the spinal cord and spinal meninges in Los Angeles County, 1972–1985. Neuroepidemiology 9:106–111

    Article  PubMed  CAS  Google Scholar 

  • Quinn JA, DeAngelis LM (2000) Neurologic emergencies in the cancer patient. Semin Oncol 27:311–321

    PubMed  CAS  Google Scholar 

  • Rades D, Karstens JH (2002) A comparison of two different radiation schedules for metastatic spinal cord compression considering a new prognostic factor. Strahlenther Onkol 178:556–561

    Article  PubMed  Google Scholar 

  • Rades D, Karstens JH, Alberti W (2002) Role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: comparison of three different fractionation schedules. Int J Radiat Oncol Biol Phys 54:1160–1164

    Article  PubMed  Google Scholar 

  • Rades D, Bajrovic A, Alberti W et al (2003a) Is there a dose-effect relationship for the treatment of symptomatic vertebral hemangioma? Int J Radiat Oncol Biol Phys 55:178–181

    Article  PubMed  Google Scholar 

  • Rades D, Fehlauer F, Schild S et al (2003b) Treatment for central neurocytoma: a meta-analysis based on the data of 358 patients. Strahlenther Onkol 179:213–218

    Article  PubMed  Google Scholar 

  • Rades D, Fehlauer F, Hartmann A et al (2004) Reducing the overall treatment time for radiotherapy of metastatic spinal cord compression (MSCC): 3-year results of a prospective observational multi-center study. J Neurooncol 70:77–82

    Article  PubMed  Google Scholar 

  • Rades D, Fehlauer F, Lamszus K et al (2005) Well-differentiated neurocytoma: what is the best available treatment? Neuro Oncol 7:77–83

    Article  PubMed  Google Scholar 

  • Ricci PE, Dungan DH (2001) Imaging of low- and intermediate-grade gliomas. Semin Radiat Oncol 11:103–112

    Article  PubMed  CAS  Google Scholar 

  • Roa W, Brasher PM, Bauman G et al (2004) Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol 22:1583–1588

    Article  PubMed  CAS  Google Scholar 

  • Ruff RL, Lanska DJ (1989) Epidural metastases in prospectively evaluated veterans with cancer and back pain. Cancer 63:2234–2241

    Article  PubMed  CAS  Google Scholar 

  • Ryu S, Jin JY, Jin R et al (2007) Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery. Cancer 109(3):628–636

    Article  PubMed  Google Scholar 

  • Sanders KE, Ha CS, Cortes-Franco JE et al (2004) The role of craniospinal irradiation in adults with a central nervous system recurrence of leukemia. Cancer 100:2176–2180

    Article  PubMed  Google Scholar 

  • Sarin R, Murthy V (2003) Medical decompressive therapy for primary and metastatic intracranial tumours. Lancet Neurol 2:357–365

    Article  PubMed  CAS  Google Scholar 

  • Sasanelli F, Beghi E, Kurland LT (1983) Primary intraspinal neoplasms in Rochester, Minnesota, 1935–1981. Neuroepidemiology 2:156–163

    Article  Google Scholar 

  • Schaberg J, Gainor BJ (1985) A profile of metastatic carcinoma of the spine. Spine 10:19–20

    Article  PubMed  CAS  Google Scholar 

  • Schiff D, Shaw EG, Cascino TL (1995) Outcome after spinal reirradiation for malignant epidural spinal cord compression. Ann Neurol 37:583–589

    Article  PubMed  CAS  Google Scholar 

  • Schiff D, Batchelor T, Wen PY (1998) Neurologic emergencies in cancer patients. Neurol Clin 16:449–483

    Article  PubMed  CAS  Google Scholar 

  • Schouten LJ, Rutten J, Huveneers HA et al (2002) Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94:2698–2705

    Article  PubMed  Google Scholar 

  • Schultheiss TE, Kun LE, Ang KK et al (1995) Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 31:1093–1112

    Article  PubMed  CAS  Google Scholar 

  • Schwartz RB et al (1991) Radiation necrosis vs high-grade recurrent glioma: differentiation by using dual-isotope SPECT with 201TI and 99mTc-HMPAO. AJNR Am J Neuroradiol 12:1187–1192

    PubMed  CAS  Google Scholar 

  • Scott CB, Scarantino C, Urtasun R et al (1998) Validation and predictive power of Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis classes for malignant glioma patients: a report using RTOG 90–06. Int J Radiat Oncol Biol Phys 40:51–55

    Article  PubMed  CAS  Google Scholar 

  • Shaw E, Scott C, Souhami L et al (2000) Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys 47(2):291–298

    Article  PubMed  CAS  Google Scholar 

  • Shaw E, Arusell R, Scheithauer B et al (2002) Prospective randomized trial of low- versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group Study. J Clin Oncol 20:2267–2276

    Article  PubMed  CAS  Google Scholar 

  • Shaw EG, Seiferheld W, Scott C et al (2003) Reexamining the Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) for glioblastoma multiforme (GBM) patients. Int J Radiat Oncol Biol Phys 57:S135–S136

    Article  Google Scholar 

  • Sheehan JP, Niranjan A, Sheehan JM et al (2005) Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium. J Neurosurg 102:678–691

    Article  PubMed  Google Scholar 

  • Shiu AS, Chang EL, Ye JS et al (2003) Near simultaneous computed tomography image-guided stereotactic spinal radiotherapy: an emerging paradigm for achieving true stereotaxy. Int J Radiat Oncol Biol Phys 57:605–613

    Article  PubMed  Google Scholar 

  • Silber JH, Radcliffe J, Peckham V, Perilongo G, Kishnani P, Fridman M et al (1992) Whole-brain irradiation and decline in intelligence: the influence of dose and age on IQ score. J Clin Oncol 10:1390–1396

    PubMed  CAS  Google Scholar 

  • Sorensen S, Helweg-Larsen S, Mouridsen H et al (1994) Effect of high-dose dexamethasone in carcinomatous metastatic spinal cord compression treated with radiotherapy: a randomised trial. Eur J Cancer 30A:22–27

    Article  PubMed  CAS  Google Scholar 

  • Stafford SL, Perry A, Suman VJ et al (1998) Primarily resected meningiomas: outcome and prognostic factors in 581 Mayo clinic patients, 1978 through 1988. Mayo Clin Proc 73:936–942

    Article  PubMed  CAS  Google Scholar 

  • Stieber VW, de Guzman AF (2003) Pituitary. In: Perez C, Brady L, Schmidt-Ullrich R, Halperin E (eds) Principles and practice of radiation oncology. Lippincott Williams and Wilkins, New York

    Google Scholar 

  • Stieber VW, Munley M (2004) Central nervous system tumors. In: Mundt AJ, Roeske JC (eds) Intensity-modulated radiation therapy: a clinical perspective. Decker, Ontario

    Google Scholar 

  • Stieber V, Tatter S, Shaw EG (2005) Primary spinal tumors. In: Schiff D (ed) Cancer of the nervous system: principles and practice of neuro-oncology. McGraw-Hill, Columbus

    Google Scholar 

  • Stupp R, Mason WP, van den Bent MJ et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996

    Article  PubMed  CAS  Google Scholar 

  • Tortosa A, Vinolas N, Villa S et al (2003) Prognostic implication of clinical, radiologic, and pathologic features in patients with anaplastic gliomas. Cancer 97:1063–1071

    Article  PubMed  Google Scholar 

  • Vedam SS et al (2003) Quantifying the predictability of diaphragm motion during respiration with a noninvasive external marker. Med Phys 30:505–513

    Article  PubMed  CAS  Google Scholar 

  • Vecht CJ, Haaxma-Reiche H, Noordijk EM et al (1993) Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33:583–590

    Article  PubMed  CAS  Google Scholar 

  • Vecht CJ, Hovestadt A, Verbiest HB et al (1994) Dose-effect relationship of dexamethasone on Karnofsky performance in metastatic brain tumors: a randomized study of doses of 4, 8, and 16 mg per day. Neurology 44:675–680

    Article  PubMed  CAS  Google Scholar 

  • Vos MJ et al (2003) Thallium-201 single-photon emission computed tomography as an early predictor of outcome in recurrent glioma. J Clin Oncol 19:3559–3565

    Article  Google Scholar 

  • Vos MJ et al (2006) Thallium-201 SPECT: the optimal prediction of response in glioma therapy. Eur J Nucl Med Mol Imaging 33:222–227

    Article  PubMed  Google Scholar 

  • Walker AE, Robins M, Weinfeld FD (1985) Epidemiology of brain tumors: the national survey of intracranial neoplasms. Neurology 35:219–226

    Article  PubMed  CAS  Google Scholar 

  • Weiss E, Krebeck M, Kohler B et al (2001) Does the standardized helmet technique lead to adequate coverage of the cribriform plate? An analysis of current practice with respect to the ICRU 50 report. Int J Radiat Oncol Biol Phys 49:1475–1480

    Article  PubMed  CAS  Google Scholar 

  • Weissman DE, Janjan NA, Erickson B et al (1991) Twice-daily tapering dexamethasone treatment during cranial radiation for newly diagnosed brain metastases. J Neurooncol 11:235–239

    Article  PubMed  CAS  Google Scholar 

  • Wolfson AH, Snodgrass SM, Schwade JG et al (1994) The role of steroids in the management of metastatic carcinoma to the brain. A pilot prospective trial. Am J Clin Oncol 17:234–238

    Article  PubMed  CAS  Google Scholar 

  • Wong DA, Fornasier VL, MacNab I (1990) Spinal metastases: the obvious, the occult, and the impostors. Spine 15:1–4

    Article  PubMed  CAS  Google Scholar 

  • Working Group on Status Epilepticus and Epilepsy Foundation of America (1993) Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America’s Working Group on Status Epilepticus. JAMA 270:854–859

    Article  Google Scholar 

  • Yamada Y, Bilsky MH, Lovelock DM et al (2008) High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys 71(2):484-490

    Article  Google Scholar 

  • Young RF, Post EM, King GA (1980) Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. J Neurosurg 53:741–748

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    William A. Hall & Walter J. Curran

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  1. William A. Hall
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  2. Walter J. Curran
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Correspondence to William A. Hall .

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Editors and Affiliations

  1. Institutet Stockholm Sweden, MMC 436, Dept.of Oncol-Pathol Karolinska, Delaware St. SE 420, Minneapolis, 55455, Minnesota, USA

    Seymour H. Levitt

  2. UC Davis Cancer Center, Dept. Radiation Oncology, University of California, Davis, X Street 4501, Sacramento, 95817, California, USA

    James A. Purdy

  3. School of Medicine, Dept. Radiation Oncology, Washington University, Forest Park Ave. 4511, St. Louis, 63108-2138, Michigan, USA

    Carlos A. Perez

  4. Instituut Verbeeten, Tilburg, 5042 SB, Netherlands

    Philip Poortmans

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Hall, W.A., Curran, W.J. (2011). Central Nervous System Tumors. In: Levitt, S., Purdy, J., Perez, C., Poortmans, P. (eds) Technical Basis of Radiation Therapy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_280

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