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Radiation Sensitizers

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Advances in Radiation Oncology in Lung Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Discovery of effective radiosensitization strategies that improve the therapeutic ratio for patients with lung cancer has been a goal of researchers and an area of vigorous investigation for the past several decades. A pure radiosensitizer is a drug, a modality of therapy or an intervention that, on its own, lacks direct anti-tumor activity but enhances the cytotoxicity of radiotherapy when employed in combination. In this chapter we outline the previous and ongoing attempts to radiosensitize lung cancers through improved tumor oxygenation, augmentation of the effectiveness of radiotherapy in hypoxic tumor cells, and use of drugs that modulate with DNA repair and apoptosis. To date, no pure radiosensitization strategy has established itself in standard practice but the current research suggests that this field continues to hold great promise for the improvement of outcome in patients with lung cancer.

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Authors and Affiliations

  1. Department of Radiation Oncology, Princess Margaret Hospital, 5-912 610 University Avenue, Toronto, ON, M5G 2M9, Canada

    Anthony M. Brade & Zishan Allibhai

  2. University of Toronto, Toronto, Canada

    Anthony M. Brade

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  1. Anthony M. Brade
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  2. Zishan Allibhai
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Correspondence to Anthony M. Brade .

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Editors and Affiliations

  1. Institute of Lung Diseases, Institutski put 4, Sremska Kamenica, 21204, Serbia

    Branislav Jeremic

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Brade, A.M., Allibhai, Z. (2011). Radiation Sensitizers. In: Jeremic, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_278

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