Skip to main content
SpringerLink
Log in

Radiologic Imaging of Lung Cancer

  • Chapter
  • First Online:
Advances in Radiation Oncology in Lung Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 1785 Accesses

Abstract

Recent advances in technology like faster, high resolution CT scanners, new data in lung cancer screening combined with many changes in the classification, staging and novel therapies for lung cancer are redefining the role imaging plays in detection, staging and management of the disease. This chapter describes the utility and limitations of the different radiological modalities in various stages of the disease. Since it is the mainstay in lung cancer management emphasis is placed on the application of CT imaging. PET-CT has been discussed separately in this volume.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • AJCC Cancer Staging Handbook - Springer Seventh Edition (2010) 253–270

    Google Scholar 

  • Akata S, Kajiwara N, Park J et al (2008) Evaluation of chest wall invasion by lung cancer using respiratory dynamic MRI. J Med Imaging Radiat Oncol 52(1):36–39

    Article  PubMed  CAS  Google Scholar 

  • Aoki T, Nakata H, Watanabe H et al (2000) Evolution of peripheral lung adenocarcinomas CT findings correlated with histology and tumor doubling time. AJR Am J Roentgenol 174:763–768

    Article  PubMed  CAS  Google Scholar 

  • Aoki T, Tomoda Y, Watanabe H (2001) Peripheral lung adenocarcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival. Radiology 220:803–809

    Article  PubMed  CAS  Google Scholar 

  • Arita T, Matsumoto T, Kuramitsu T et al (1996) Is it possible to differentiate malignant mediastinal nodes from benign nodes by size? Reevaluation by CT, transesophageal echocardiography, and nodal specimen. Chest 110(4):1004–1008

    Article  PubMed  CAS  Google Scholar 

  • Awai K, Murao K, Ozawa A et al (2004) Pulmonary nodules at chest CT: effect of computer-aided diagnosis on radiologists’ detection performance. Radiology 230:347–352

    Article  PubMed  Google Scholar 

  • Bittner RC, Felix R (1998) Magnetic resonance (MR) imaging of the chest: state-of-the art. Eur Respir J 11:1392–1404

    Article  PubMed  CAS  Google Scholar 

  • Cascade N, Gross BH, Kazerooni EA, Quint LE, Francis IR, Strawderman M, Korobkin M (1998) Variability in the detection of enlarged mediastinal lymph nodes in staging lung cancer: a comparison of contrast-enhanced and unenhanced CT. Am J Roentgenol 170:927–931

    Article  CAS  Google Scholar 

  • Detterbeck FC, Jantz M, Wallace M et al (2007) Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 132(Suppl 3):202S–220S

    Article  PubMed  Google Scholar 

  • Erasmus JJ, Sabloff BS (2008) CT, positron emission tomography, and MRI in staging lung cancer. Clin Chest Med 29(1):39–57

    Article  PubMed  Google Scholar 

  • Gorlova O, Peng B, Yankelevitz D, Henschke C, Kimmel M (2005) Estimating the growth rates of primary lung tumours from samples with missing measurements. Stat Med 24(7):1117–1134, 4/2005. PMID: 15568189

    Google Scholar 

  • Gu P, Zhao YZ, Jiang LY et al (2009) Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and metaanalysis. Eur J Cancer 45:1389–1396

    Article  PubMed  Google Scholar 

  • Hansell DM, Lynch DA, Page McAdams H, Bankier AA (2010) Imaging of diseases of the chest, 5th edn. Elsevier publications, Philadelphia

    Google Scholar 

  • Heelan RT, Demas BE, Caravelli JF et al (1989) Superior sulcus tumors: CT and MR imaging. Radiology 170(3 Pt 1):637–641

    PubMed  CAS  Google Scholar 

  • Henschke CI, Yankelevitz DF, Mirtchev R et al (2002) The ELCAP group, CT screening for lung cancer frequency and significance of part-solid and nonsolid nodules. AJR Am J Roentgenol 178:1053–1057

    Article  PubMed  Google Scholar 

  • Henschke CI, Boffetta P, Gorlova O, et al (2010) Assessment of lung-cancer mortality reduction from CT screening. Lung Cancer 16 (PubMed PMID:21168236)

    Google Scholar 

  • Hierholzer J, Luo L, Bittner RC et al (2000) MRI and CT in the differential diagnosis of pleural disease. Chest 118:604–660

    Article  PubMed  CAS  Google Scholar 

  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer Statistics. CA Cancer J Clin [Epub ahead of print]

    Google Scholar 

  • Johnson BE (1998) Second lung cancers in patients after treatment for an initial lung cancer. J Natl Cancer Inst 90(18):1335–1345

    Article  PubMed  CAS  Google Scholar 

  • Klein JS, Braff S (2008a) Imaging evaluation of the solitary pulmonary nodule. Clin Chest Med 29(1):15–38

    Article  PubMed  Google Scholar 

  • Klein JS, Braff S (2008b) Imaging evaluation of the solitary pulmonary nodule. Clin Chest Med 29:15–38

    Article  PubMed  Google Scholar 

  • Kundel HL (1981) Predictive value and threshold of detectability of lung tumors. Radiology 139:25–29

    PubMed  CAS  Google Scholar 

  • Kuriyama K, Tateishi R, Doi O, Higashiyama M, Kodama K et al (1991) Prevalence of air bronchograms in small peripheral carcinomas of the lung on thin-section CT: comparison with benign tumors. AJR, Am J Roentgenol 156:921–924

    Article  CAS  Google Scholar 

  • Lau CL, Harpole DH Jr (2000) Noninvasive clinical staging modalities for lung cancer. Semin Surg Oncol 18(2):116–123

    Article  PubMed  CAS  Google Scholar 

  • Libby DM, Smith JP, Altorki NK et al (2004) Managing the small pulmonary nodule discovered by CT. Chest 125:1522–1529

    Article  PubMed  Google Scholar 

  • Marom EM, McAdams HP, Erasmus JJ et al (1999) Staging non–small cell lung cancer with whole-body PET. Radiology 212:803–809

    PubMed  CAS  Google Scholar 

  • Muhm JR, Miller WE, Fontana RS, Sanderson DR, Uhlenhopp MA (1983) Lung cancer detected during a screening program using four month chest radiographs. Radiology 148:609–615

    PubMed  CAS  Google Scholar 

  • National cancer Institute. www.cancer.gov NSLT Lung cancer trial results show mortality benefit with low-dose CT Twenty percent fewer lung cancer deaths seen among those who were screened with low-dose spiral CT than with chest X-ray (Posted: 11/04/2010)

  • O’Connor J, Jackson A, Asselin M, Buckley D, Parker G, Jayson G (2008) Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives. Lancet Oncol 9(8):766–776

    Article  PubMed  Google Scholar 

  • Padhani AR, Ollivier L (2001) The RECIST criteria: implications for diagnostic radiologists. Br J Radiol 74:983–986

    PubMed  CAS  Google Scholar 

  • Patz EF Jr, Erasmus JJ, McAdams HP et al (1999) Lung cancer staging and management: comparison of contrast-enhanced and nonenhanced helical CT of the thorax. Radiology 212:56–60

    PubMed  Google Scholar 

  • Primack SL, Lee KS, Logan PM et al (1994) Bronchogenic carcinoma: utility of CT in the evaluation of patients with suspected lesions. Radiology 193:795–800

    PubMed  CAS  Google Scholar 

  • Ravenel JG, Mohammed TLH, Movsas B, Ginsburg ME et al (2010) ACR Appropriateness criterias noninvasive clinical staging of bronchogenic carcinoma. J Thorac Imaging 25(4):W107–W111

    Article  PubMed  Google Scholar 

  • Revel M, Lefort C, Bissery A et al (2004) Pulmonary nodules: preliminary experience with three-dimensional evaluation. Radiology 231:459–466

    Article  PubMed  Google Scholar 

  • Rusch V et al (2009) The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 4(5):568–577

    Article  PubMed  Google Scholar 

  • Sieren JC, Ohno Y, Koyama H et al (2010) Recent technological and application developments in computed tomography and magnetic resonance imaging for improved pulmonary nodule detection and lung cancer staging. J Magn Resonance Imaging 32:1353–1369

    Article  Google Scholar 

  • Simon GR, Turrisi A (2007) American College of Chest Physicians, Management of small cell lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 132(3 Suppl):324S–339S

    Article  PubMed  CAS  Google Scholar 

  • The National Lung Screening Trial: Overview and Study Design Published online before print November 2, 2010, doi:10.1148/radiol.10091808, January 2011 Radiology 258:243–253

  • Toh CK (2009) The changing epidemiology of lung cancer. Methods Mol Biol 472:397–411

    Article  PubMed  Google Scholar 

  • Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC (eds) (2004) World Health Organization lung, pleura, thymus and heart. Pathology & Genetics tumours of the lung, pleura thymus and heart. IARC Press, Lyon

    Google Scholar 

  • Travis WD, Brambilla E, Noguchi M, Nicholson AG (2011) International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6(2):244–285

    Article  PubMed  Google Scholar 

  • UyBico SJ, Wu CC, Suh RD, Le NH, Brown K, Krishnam MS (2010) Lung cancer staging essentials: the new TNM Staging system and potential imaging pitfalls. Radiographics 30:1163–1181 doi:10.1148/rg.305095166

    Article  PubMed  Google Scholar 

  • van Klaveren RJ, Oudkerk M, Prokop M (2009) Management of lung nodules detected by volume CT scanning. N Engl J Med 361:2221–2229

    Article  PubMed  Google Scholar 

  • Vansteenkistel J, Dooms C, De Leyn P (2010) Early stage non-small-cell lung cancer: challenges in staging and adjuvant treatment: evidence-based staging. Ann Oncol 21(Supplement 7):vii189–vii195

    Article  PubMed  Google Scholar 

  • Walsh GL et al (1995) Is follow-up of lung cancer patients after resection medically indicated and cost-effective? Ann Thorac Surg 60(6):1563–1570 discussion 1570-2, 12/1995

    Article  PubMed  CAS  Google Scholar 

  • Yankelevitz DF, Henschke CI et al (1997) Does 2-year stability imply that pulmonary nodules are benign? AJR Am J Roentgenol 168(2):325–328

    Article  PubMed  CAS  Google Scholar 

  • Zerhouni EA, Stitik FP, Siegelman SS et al (1986) CT of the pulmonary nodule: a cooperative study. Radiology 160:319–327

    PubMed  CAS  Google Scholar 

  • Zwirewich C, Vedal S, Miller R, Muller N (1991) Solitary pulmonary nodule:High-resolution CT and radiologic-pathologic correlation. Radiology 179:469

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Rush University, Chicago, IL, USA

    Palmi Shah

  2. Department of Internal Medicine, Rush University, Chicago, IL, USA

    James L. Mulshine

Authors
  1. Palmi Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James L. Mulshine
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James L. Mulshine .

Editor information

Editors and Affiliations

  1. Institute of Lung Diseases, Institutski put 4, Sremska Kamenica, 21204, Serbia

    Branislav Jeremic

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Shah, P., Mulshine, J.L. (2011). Radiologic Imaging of Lung Cancer. In: Jeremic, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_267

Download citation

  • DOI: https://doi.org/10.1007/174_2011_267

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-19924-0

  • Online ISBN: 978-3-642-19925-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation