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Stereotactic Body Radiotherapy

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Technical Basis of Radiation Therapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Stereotactic body radiation therapy (SBRT) combines the latest advancements in image guidance, planning, and treatment delivery to direct tumoricidal doses to the target. This is accomplished with acceptable sparing of normal tissues which was not practical or feasible with traditional techniques. Over the last decade, SBRT is evolving and in some areas has been established as the contemporary standard of care. This is especially the case in inoperable non-small cell lung cancers, where it has emerged as highly effective with successful results that have been reproduced around the world. Several other applications of SBRT require continued studies and careful design of additional prospective studies. The technique demands the latest developments in patient immobilization, dosimetry planning, and delivery of the intended dose to the target using near real-time imaging and precise assessment of expected tumor motion during the treatment. In addition, dosimetric parameters must spare a significant portion of functional subunits in the adjacent normal tissues. A careful consideration in selection of eligible patients cannot be stressed enough. Increased efficacy combined with convenient fractionation schedule remains highly attractive for patients. Long-term results with favorable outcomes with similar or reduced treatment-related morbidity will further accelerate the acceptance of SBRT.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Minnesota Medical Center, 420 Delaware St, SE MMC-494, Minneapolis, MN, 55455, USA

    L. Chinsoo Cho

  2. Department of Radiotherapy-Oncology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    Valérie Fonteyne & Wilfried DeNeve

  3. Department of Radiation Oncology, Case Western Reserve University, University Hospitals Case Medical Center, 11100 Euclid Avenue, Lerner Tower B 181, Cleveland, OH, 44106, USA

    Simon S. Lo

  4. Department of Radiation Oncology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX, 75390-9183, USA

    Robert D. Timmerman

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  1. L. Chinsoo Cho
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  2. Valérie Fonteyne
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  3. Wilfried DeNeve
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  4. Simon S. Lo
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  5. Robert D. Timmerman
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Correspondence to L. Chinsoo Cho .

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Editors and Affiliations

  1. Institutet Stockholm Sweden, MMC 436, Dept.of Oncol-Pathol Karolinska, Delaware St. SE 420, Minneapolis, 55455, Minnesota, USA

    Seymour H. Levitt

  2. UC Davis Cancer Center, Dept. Radiation Oncology, University of California, Davis, X Street 4501, Sacramento, 95817, California, USA

    James A. Purdy

  3. School of Medicine, Dept. Radiation Oncology, Washington University, Forest Park Ave. 4511, St. Louis, 63108-2138, Michigan, USA

    Carlos A. Perez

  4. Instituut Verbeeten, Tilburg, 5042 SB, Netherlands

    Philip Poortmans

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Cho, L.C., Fonteyne, V., DeNeve, W., Lo, S.S., Timmerman, R.D. (2011). Stereotactic Body Radiotherapy. In: Levitt, S., Purdy, J., Perez, C., Poortmans, P. (eds) Technical Basis of Radiation Therapy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_263

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