Abstract
The role of Photodynamic Therapy (PDT) in the current multi-disciplinary approach to thoracic oncology is analyzed and reviewed. The simplicity of drug, light and reaction resulting in excellent clinical response has brought PDT to a worldwide audience. This chapter reviews the scientific and clinical rationale for thoracic PDT including photosensitizers, light sources, photodynamic reaction, dosimetry and fluorescence. The actual treatment procedure, clinical outcomes from the peer reviewed literature, limitations and morbidities associated with this light-based therapy are also detailed.
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References
Allison RR, Sibaba CH (2010) Oncologic photodynamic therapy photo sensitizers: a clinical review. Photodiagnosis Photodyn Ther 7:61–75
Allison RR, Sibata CH (2008) Photodiagnosis for cutaneous malignancy: a brief clinical and technical review. Photodiagnosis Photodyn Ther 5:247–250
Allison RR, Mota HC, Sibata CH (2004a) Clinical PD/PDT in North America: An Historical Review. Photodiagnosis Photodyn Ther 1:263–277
Allison RR, Downie GH, Cuenca R, Hu XH, Childs CJH, Sibata CH (2004b) Photosensitizers in clinical PDT. Photodiagnosis Photodyn Ther 1:27–42
Cortese DA, Edell ES, Kinsey JH (1998) Photodynamic therapy for early stage squamous cell carcinoma of the lung. Mayo Clinic Proc 72:595–602
Daniell MD, Hill JS (1991) A history of photodynamic therapy. Aust N Z J Surg 61:340–348
DeArmond DT, Mahtabifard A, Fuller CB, McKenna RJ Jr (2008) Photodynamic therapy followed by thoracoscopic sleeve lobectomy for locally advanced lung cancer. Ann Thorac Surg 85:e24–e26
Dooms C, Seijo L, Gasparini S, Trisolini R, Ninane V, Tournoy KG (2010) Diagnostic bronchoscopy: state of the art. Eur Respir Rev 19:229–236
Dougherty TJ (1996) A brief history of clinical photodynamic therapy development at Rosewell Park Cancer Institute. J Clin Laser Med Surg 14:219–221
Dougherty TJ, Marcus SL (1992) Photodynamic therapy. Eur J Cancer 10:1734–1742
Du KL, Both S, Friedberg JS, Rengan R, Hahn SM, Cengel KA (2010) Extrapleural pneumonectomy, photodynamic therapy and intensity modulated radiation therapy for the treatment of malignant pleural mesothelioma. Cancer Biol Ther 10:425–429
Freitag L, Ernst A, Thomas M, Prenzel R, Wahlers B, Macha HN (2004) Sequential photodynamic therapy (PDT) and high dose brachytherapy for endobronchialtumour control in patients with limited bronchogenic carcinoma. Thorax 59:790–793
Friedberg JS, Mick R, Stevenson JP, Zhu T, Busch TM, Shin D, Smith D, Culligan M, Diofte A, Clatstein E, Hahn SM (2004) Phase II trial of pleural photodynamic therapy and surgery for patients with non-small-cell lung cancer with pleural spread. J Clin Oncol 22:2192–2201
Furukawa K, Kato H, Konaka C, Okunaka T, Usada J, Ebihara Y (2005) Locally recurrent central type early stage lung cancer <1.0 cm in diameter after complete remission by Photodynamic Therapy. Chest 128:3264–3275
Furuse K, Fukuoka M, Kato H et al (1993) A prospective Phase II stude on Photodynamic Therapy with Photofrin II for centrally located early stage lunch cancer. J Clin Oncol 11:1852–1857
Jung EJ, Lee JH, Jeon K, Koh WJ, Suh GY, Chung MP, Kim H, Kwon OJ, Shim YM, Um SW (2010) Treatment outcomes for patients with synchronous multiple primary non-small cell lung cancer. Lung Cancer, Dec 8, [Epub ahead of print]
Kato H, Okunaka T, Shimatani H (1996) Photodynamic therapy for early stage bronchogenic carcinoma. J Clin Laser Med Surg 14:235–238
Kato H, Furukawa K, Sato M, Okunaka T, Kusunoki Y, Kawahara M, Fukuoka M, Miyazawa T, Yana T, Matsui K, Shiraishi T, Horinouchi H (2003) Phase II clinical study of photodynamic therapy using mono-L-aspartylchlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer 42:103–111
Lam S, Kostashuk EC, Coy EP, Laukkanen E, LeRiche JC, Meuller HA, Szasz IJ (1987) A randomized comparative study of the safety and efficacy of photodynamic therapy using Photofrin II combined with palliative radiotherapy versus palliative radiotherapy alone in patients with inoperable obstructive non-small cell bronchogenic carcinoma. Photochem Photobiol 46:893–897
Mang TS, Dougherty TJ, Potter WR, Botle DG, Somer S, Moan J (1987) Photobleaching of poryrins used in photodynamic therapy and implications for therapy. Photochem Photobiol 45:501–506
Minnich DJ, Bryant AS, Dooley A, Cerfolio RJ (2010) Photodynamic laser therapy for lesions in the airway. Ann Thorac Surg 89:1744–1748
Miyazu Y, Miyazawa T, Kurimoto N, Iwamoto Y, Kanoh K, Kohno N (2002) Endobronchial ultrasonography in the assessment of centrally located early stage lung cancer before photodynamic therapy. Am J Respir Crit Care Med 165:832
Moghissi K, Dixon K, Parson RJ (1993) A controlled trial of ND-YAG lasers vs photodynamic therapy for advanced malignant bronchial obstruction. Lasers Med Sci 8:269–273
Moghissi K, Dixon K (2003) Is bronchoscopic photodynamic therapy a therapeutic option in lung cancer? Eur Respir J 22:535–541
Moghissi K, Dixon K (2008) Update on the current indications, practice and results of photodynamic therapy (PDT) in early central lung cancer (ECLC). Photodiagnosis Photodyn Ther 5:10–18
Moghissi K, Dixon K, Stringer M, Freeman T, Thorpe A, Brown S (1999) The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer: experience of 100 cases. Eur J Cardiothorac Surg 15:1–6
Moghissi K, Dixon K, Thorpe JA (2003) A method for video-assisted thoracoscopic photodynamic therapy (VAT-PDT). Interact Cardiovasc Thorac Surg 2:373–375
Moghissi K, Dixon K, Thorpe JAC, Stringer MR (2007) Photodynamic theray in early central lung cancer: a treatment option for patients ineligible for surgical resection. Thorax 65:391–395
Mortman KD, Frankel KM (2006) Pulmonary resection after successful downstaging with photodynamic therapy. Ann Thorac Surg 82:722–724
Okunaka T, Kato H, Tsutsui H, Ishizumi T, Ichinose S, Kuroiwa Y (2004) Photodynamic therapy for peripheral lung cancer. Lung Cancer 43:77–82
Okunaka T, Hyoshi T, Furukawa K, Yamamoto H, Tsuchida T, Usuda J, Kumasaka H, Ishida J, Konaka C, Kato H (1999) Lung cancer treated with photodynamic therapy and surgery. Diagn Ther Endosc 5:155–160
Raab O (1900) On the effect of fluorescent substances on infusoria (German). Z Bilogoy 39:524
Ross P Jr, Grecula J, Bekaii-Saab T, Villalona-Calero M, Otterson G, Magro C (2006) Incroporation of photodynamic therapy as an induction modality in non-small cell lung cancer. Lasers Surg Med 38:881–889
Sanfilippo NJ, HIS A, DeNittis AS, Ginsberg GG, Kochman ML, Friedberg JS, Hahn SM (2001) Toxicity of photodynamic therapy after combined external beam radiotherapy and intraluminal brachytherapy for carcinoma of the upper areodigestive tract. Lasers Surg Med 28:278–281
Santos RS, Radtopoulos Y, Keenan RJ, Jalal A, Maley RH, Landreneau RJ (2004) Bronchoscopic palliation of primary lung cancer: single or multimodality therapy? Surg Endosc 18:9316
Sibata CH, Colussi VC, Oleinick NL, Kinsella TJ (2000) Photodynamic therapy: a new concept in medical treatment. Braz J Med Biol Res 33:869–880
Sokolov VV, Telegina LV, Trakhtenberg AKH, Kolbanov KI, Pikin OV, Frank GA (2010) Enodobronchial surgery and photodynamic therapy for the treatment of multiple primary lung cancer. Khirurhiia 7:28–31
Usuda J, Tsutsui H, Honda H, Ichinose S, Ishizumi T, Hirata T, Inoue T, Ohtani K, Maehara S, Imai K, Tsunoda Y, Kubota M, Ikeda N, Furukawa K, Okunaka T, Kato H (2007) Photodynamic therapy for lung cancers based on novel photodynamic diagnosis using talaporfin sodium (NPe6) and autofluorescence bronchoscopy. Lung Cancer 58:317–323
Usuda J, Ichinose S, Ishizumi T, Hayashi H, Ohtani K, Maehara S, Ono S, Kajiwara N, Uchida O, Tsutsui H, Ohira T, Kato H, Ikeda N (2010) Management of multiple primary lung cancer in patients with centrally located early cancer lesions. J Thorac Oncol 5:62–68
Von Tappeiner H, Jesionek A (1907) The sensitizing action of fluorescent substances. An overall account of investigations on photodynamic phenomena. Leipzig, F.C.W. Vogel
Von Tappeiner H, Jesionek A (1903) TherapeutischeVersuchemitfloreszierendenStofffen (Therapeutic experiments with fluorescent substances). Muench Med Wochenscr 47:2042–2044
Weigel TL, Kosco PJ, Dacic S, Yousem S, Luketich JD (1999) Fluorescence bronchoscopic surveillance in patients with a history of non-small cell lung cancer. Diagn Ther Endosc 6:1–7
Weinberg BD, Allison RR, Sibata C, Parent T, Downie G (2010) Results of combined photodynamic therapy (PDT) and high dose brachytherapy (HDR) in treatment of obstructive endobronchial non-small cell lung cancer (NSCLC). Photodiagnosis Photodyn Ther 7:50–58
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Allison, R.R. (2011). PDT-Lung. In: Jeremic, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_220
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DOI: https://doi.org/10.1007/174_2011_220
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