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Technical Aspects of Radiation Therapy in Endometrial Carcinoma

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Technical Basis of Radiation Therapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

An estimated 43,470 new cases of EC are expected in the US in 2010 with 7,950 estimated deaths (American Cancer Society Cancer facts and figures 2010. American Cancer Society, Atlanta, 2010). Currently, EC is the fourth most common cancer in females, ranking behind breast, bowel, and lung cancer. In over 80% of the cases, the disease is confined to the uterus and cervix at the time of diagnosis, and uncorrected survival rates of 75% or greater are expected (Pecorelli Int J Gynaecol Obstet 105(2):103–104, 2009). In the last 25 years, the treatment of EC has evolved from almost routine use of preoperative radiotherapy (RT), generally intracavitary brachytherapy, followed by hysterectomy, to upfront surgical staging followed by tailored adjuvant therapy based on histopathological findings, as recommended by the International Federation of Gynecology and Obstetrics (FIGO Int J Gynecol Obstet 28:189–193, 1989). The purpose of this chapter is to review the role and technical aspects of external beam RT (EBRT) and brachytherapy in the management of EC as well as describing the radiotherapeutic approach as definitive therapy for medically inoperable patients and in the salvage setting for recurrent disease.

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Authors and Affiliations

  1. Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Drive, RT 041, Indianapolis, IN, 46202, USA

    Higinia R. Cárdenes, David L. Andolino & Jennifer E. Zook

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  1. Higinia R. Cárdenes
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  2. David L. Andolino
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  3. Jennifer E. Zook
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Correspondence to Higinia R. Cárdenes .

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Editors and Affiliations

  1. Institutet Stockholm Sweden, MMC 436, Dept.of Oncol-Pathol Karolinska, Delaware St. SE 420, Minneapolis, 55455, Minnesota, USA

    Seymour H. Levitt

  2. UC Davis Cancer Center, Dept. Radiation Oncology, University of California, Davis, X Street 4501, Sacramento, 95817, California, USA

    James A. Purdy

  3. School of Medicine, Dept. Radiation Oncology, Washington University, Forest Park Ave. 4511, St. Louis, 63108-2138, Michigan, USA

    Carlos A. Perez

  4. Instituut Verbeeten, Tilburg, 5042 SB, Netherlands

    Philip Poortmans

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Cárdenes, H.R., Andolino, D.L., Zook, J.E. (2011). Technical Aspects of Radiation Therapy in Endometrial Carcinoma. In: Levitt, S., Purdy, J., Perez, C., Poortmans, P. (eds) Technical Basis of Radiation Therapy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_156

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  • DOI: https://doi.org/10.1007/174_2011_156

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