Abstract
EUS has shown to be superior to other imaging techniques in the diagnosis of pancreatic cancer, especially in tumors < 2cm in diameter. Since the negative predictive value of EUS is 95-100%, EUS should be considered the technique of choice to rule out pancreatic cancer in patients with clinical suspicion and inconclusive previous image techniques. However, there is no agreement on the best technique (EUS or CT) to stage and assess ressectability in pancreatic adenocarcinoma. The most reliable sequential approach consists of a helical CT as the initial test and EUS as a confirmatory technique. EUS FNA is the most accurate and safe modality for tissue diagnosis in patients with suspected pancreatic cancer and is mandatory in unresectable disease. In the case of resectable tumors, the need of EUS FNA is still controversial.
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References
Ahmad NA (2000) EUS in preoperative staging of pancreatic cancer. Gastrointest Endosc 52:463–468
Agarwal B (2004) Endoscopic ultrasound-guided fine needle aspiration and multidetector spiral CT in the diagnosis of pancreatic cancer. Am J Gastroenterol 99:844–850
Bournet B (2006) Early morbidity of endoscopic ultrasound: 13 years’ experience at a referral center. Endoscopy 38:349–354
Buthani MS (2004) The no endosonographic detection of tumor (NEST) study: a case series of pancreatic cancers missed on endoscopic ultrasonography. Endoscopy 36:385–389
Chang KJ (1997) The clinical utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma. Gastrointest Endosc 45:387–393
DeWitt J (2004) Comparison of endoscopic ultrasonography and multidetector computed tomography for detecting and staging pancreatic cancer. Ann Intern Med 141:753–763
DeWitt J (2005) EUS-guided FNA of pancreatic metastases: a multicenter experience. Gastrointest Endosc 61:689–696
Eloubeidi MA (2004) Acute pancreatitis after EUS-guided FNA of solid pancreatic masses: a pooled analysis from EUS centers in the United States. Gastrointest Endosc 60:385–389
Fernández-Esparrach G (2007) Incidence and clinical significance of hyperamylasemia after endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic lesions: a prospective and controlled study. Endoscopy 39:720–724
Giovannini M (1995) Fine-needle aspiration cytology guided by endoscopic ultrasonography: results in 141 patients. Endoscopy 27:171–177
Gress FG (1997) Endoscopic ultrasound-guided fine-needle aspiration biopsy using linear array and radial scanning endosonography. Gastrointest Endosc 45:243–250
Gress FG (1999) Role of endoscopic ultrasound in the preoperative staging of pancreatic cancer: a large single-center experience. Gastrointest Endosc 50:786–791
Itoi T (2005) Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonongraphy-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses. Oncol Rep 13:229–234
Khalid A (2006) Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses. Am J Gastroenterol 101:2493–2500
Klapman JB (2005) Negative predictive value of endoscopic ultrasound in a large series of patients with a clinical suspicion of pancreatic cancer. Am J Gastroenterol 100:1–4
Krishna NB (2009) Diagnostic value of EUS-FNA in patients suspected of having pancreatic cancer with a focal lesion on CT scan/MRI but without obstructive jaundice. Pancreas 38:625–630
Levy MJ (2006) Chronic pancreatitis: focal pancreatitis or cancer. is there a role for FNA/biopsy? Autoimmune pancreatitis. Endoscopy 38(suppl 1):S30–S35
Levy MJ (2007) Endoscopic ultrasound-guided trucut biopsy of the pancreas: prospects and problems. Pancreatology 7:163–166
Mertz HR (2000) EUS, PET, and CT scanning for evaluation of pancreatic adenocarcinoma. Gastrointest Endosc 52:367–371
Micames C (2003) Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-FNA vs. percutaneous FNA. Gastrointest Endosc 58:690–695
Mishra G (2006) Determination of qualitative telomerase activity as an adjunct to the diagnosis of pancreatic adenocarcinoma by EUS-guided fine-needle aspiration. Gastrointest Endosc 63:648–654
Mortensen MB (2005) Prospective evaluation of patient tolerability, satisfaction with patient information, and complications in endoscopic ultrasonography. Emdoscopy 37:146–153
Muller MF (1994) Pancreatic tumors: evaluation with endoscopic US, CT and MR imaging. Radiology 190:745–751
Pellisé M (2003) Usefulness of KRAS mutational analysis in the diagnosis of pancreatic adenocarcinoma by means of endosonography-guided fine-needle aspiration biopsy. Aliment Pharmacol Ther 17:1299–1307
Puli SR (2007) Diagnostic accuracy of EUS for vascular invasion in pancreatic and periampullary cancers: a meta-analysis and systematic review. Gastrointest Endosc 65:788–797
Raut C (2003) Diagnostic accuracy of endoscopic-ultrasound guided fine-needle aspiration in patients with presumed pancreatic cancer. J Gastrointest Surg 7:118–128
Rösch T (1990) Preoperative localization of endocrine tumors of the pancreas: endoscopic ultrasound is superior to transabdominal sonography and computed tomography. Gastrointest Endosc 36:199–200
Rösch T (1991) Endoscopic ultrasound in pancreatic tumor diagnosis. Gastrointest Endosc 37:347–352
Rösch T (1992) Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography. Comparison with conventional sonography, computed tomography and angiography. Gastroenterology 102:188–199
Rösch T (2000) Endoscopic ultrasound criteria of vascular invasion in the staging of pancreatic head cancer: a blinded reevaluation of videotapes. Gastrointest Endosc 52:469–477
Rösch T, Classen M (1992) Gastroenterologic endosonography. Textbook and atlas. Thieme Verlag, New York
Snady H (1992) Endoscopic ultrasonography compared with computed tomography with ERCP in patients with obstructive jaundice or small peri-pancreatic mass. Gastrointest Endosc 38:27–34
Soriano A (2004) Preoperative staging and tumor respectability assessment on pancreatic cancer: prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography. Am J Gastroenterol 99:492–501
Tada M (2002) Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: clinikcal utility for diagnosis of pancreatic tumor. Am J Gastroenterol 97:2263–2270
Wiersema MJ (1997) Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment. Gastrointest Endosc 112:1087–1095
Wiersema MJ (2001) Accuracy of endoscopic ultrasonography in diagnosis and staging pancreatic carcinoma. Pancreatology 1:625–632
Williams DB (1999) Endoscopic ultrasound guided fine needle aspiration biopsy: a large centre experience. Gut 44:720–726
Yasuda K (1988) The diagnosis of pancreatic cancer by endoscopic ultrasonography. Gastrointest Endosc 34:1–8
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Ginès, A., Fernández-Esparrach, G., Ayuso, C. (2010). Endoscopic Ultrasonography in Pancreatic Tumors: When and Why?. In: Laghi, A. (eds) New Concepts in Diagnosis and Therapy of Pancreatic Adenocarcinoma. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_50
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