Skip to main content

Endoscopic Ultrasonography in Pancreatic Tumors: When and Why?

  • Chapter
  • First Online:
New Concepts in Diagnosis and Therapy of Pancreatic Adenocarcinoma

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

  • 886 Accesses

Abstract

EUS has shown to be superior to other imaging techniques in the diagnosis of pancreatic cancer, especially in tumors < 2cm in diameter. Since the negative predictive value of EUS is 95-100%, EUS should be considered the technique of choice to rule out pancreatic cancer in patients with clinical suspicion and inconclusive previous image techniques. However, there is no agreement on the best technique (EUS or CT) to stage and assess ressectability in pancreatic adenocarcinoma. The most reliable sequential approach consists of a helical CT as the initial test and EUS as a confirmatory technique. EUS FNA is the most accurate and safe modality for tissue diagnosis in patients with suspected pancreatic cancer and is mandatory in unresectable disease. In the case of resectable tumors, the need of EUS FNA is still controversial.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahmad NA (2000) EUS in preoperative staging of pancreatic cancer. Gastrointest Endosc 52:463–468

    Article  PubMed  CAS  Google Scholar 

  • Agarwal B (2004) Endoscopic ultrasound-guided fine needle aspiration and multidetector spiral CT in the diagnosis of pancreatic cancer. Am J Gastroenterol 99:844–850

    Article  PubMed  Google Scholar 

  • Bournet B (2006) Early morbidity of endoscopic ultrasound: 13 years’ experience at a referral center. Endoscopy 38:349–354

    Article  PubMed  CAS  Google Scholar 

  • Buthani MS (2004) The no endosonographic detection of tumor (NEST) study: a case series of pancreatic cancers missed on endoscopic ultrasonography. Endoscopy 36:385–389

    Article  Google Scholar 

  • Chang KJ (1997) The clinical utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma. Gastrointest Endosc 45:387–393

    Article  PubMed  CAS  Google Scholar 

  • DeWitt J (2004) Comparison of endoscopic ultrasonography and multidetector computed tomography for detecting and staging pancreatic cancer. Ann Intern Med 141:753–763

    Article  PubMed  Google Scholar 

  • DeWitt J (2005) EUS-guided FNA of pancreatic metastases: a multicenter experience. Gastrointest Endosc 61:689–696

    Article  PubMed  Google Scholar 

  • Eloubeidi MA (2004) Acute pancreatitis after EUS-guided FNA of solid pancreatic masses: a pooled analysis from EUS centers in the United States. Gastrointest Endosc 60:385–389

    Article  PubMed  Google Scholar 

  • Fernández-Esparrach G (2007) Incidence and clinical significance of hyperamylasemia after endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic lesions: a prospective and controlled study. Endoscopy 39:720–724

    Article  PubMed  Google Scholar 

  • Giovannini M (1995) Fine-needle aspiration cytology guided by endoscopic ultrasonography: results in 141 patients. Endoscopy 27:171–177

    Article  PubMed  CAS  Google Scholar 

  • Gress FG (1997) Endoscopic ultrasound-guided fine-needle aspiration biopsy using linear array and radial scanning endosonography. Gastrointest Endosc 45:243–250

    Article  PubMed  CAS  Google Scholar 

  • Gress FG (1999) Role of endoscopic ultrasound in the preoperative staging of pancreatic cancer: a large single-center experience. Gastrointest Endosc 50:786–791

    Article  PubMed  CAS  Google Scholar 

  • Itoi T (2005) Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonongraphy-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses. Oncol Rep 13:229–234

    PubMed  CAS  Google Scholar 

  • Khalid A (2006) Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses. Am J Gastroenterol 101:2493–2500

    Article  PubMed  CAS  Google Scholar 

  • Klapman JB (2005) Negative predictive value of endoscopic ultrasound in a large series of patients with a clinical suspicion of pancreatic cancer. Am J Gastroenterol 100:1–4

    Article  Google Scholar 

  • Krishna NB (2009) Diagnostic value of EUS-FNA in patients suspected of having pancreatic cancer with a focal lesion on CT scan/MRI but without obstructive jaundice. Pancreas 38:625–630

    Article  PubMed  Google Scholar 

  • Levy MJ (2006) Chronic pancreatitis: focal pancreatitis or cancer. is there a role for FNA/biopsy? Autoimmune pancreatitis. Endoscopy 38(suppl 1):S30–S35

    Article  PubMed  Google Scholar 

  • Levy MJ (2007) Endoscopic ultrasound-guided trucut biopsy of the pancreas: prospects and problems. Pancreatology 7:163–166

    Article  PubMed  Google Scholar 

  • Mertz HR (2000) EUS, PET, and CT scanning for evaluation of pancreatic adenocarcinoma. Gastrointest Endosc 52:367–371

    Article  PubMed  CAS  Google Scholar 

  • Micames C (2003) Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-FNA vs. percutaneous FNA. Gastrointest Endosc 58:690–695

    Article  PubMed  Google Scholar 

  • Mishra G (2006) Determination of qualitative telomerase activity as an adjunct to the diagnosis of pancreatic adenocarcinoma by EUS-guided fine-needle aspiration. Gastrointest Endosc 63:648–654

    Article  PubMed  Google Scholar 

  • Mortensen MB (2005) Prospective evaluation of patient tolerability, satisfaction with patient information, and complications in endoscopic ultrasonography. Emdoscopy 37:146–153

    Article  CAS  Google Scholar 

  • Muller MF (1994) Pancreatic tumors: evaluation with endoscopic US, CT and MR imaging. Radiology 190:745–751

    PubMed  CAS  Google Scholar 

  • Pellisé M (2003) Usefulness of KRAS mutational analysis in the diagnosis of pancreatic adenocarcinoma by means of endosonography-guided fine-needle aspiration biopsy. Aliment Pharmacol Ther 17:1299–1307

    Article  PubMed  Google Scholar 

  • Puli SR (2007) Diagnostic accuracy of EUS for vascular invasion in pancreatic and periampullary cancers: a meta-analysis and systematic review. Gastrointest Endosc 65:788–797

    Article  PubMed  Google Scholar 

  • Raut C (2003) Diagnostic accuracy of endoscopic-ultrasound guided fine-needle aspiration in patients with presumed pancreatic cancer. J Gastrointest Surg 7:118–128

    Article  PubMed  Google Scholar 

  • Rösch T (1990) Preoperative localization of endocrine tumors of the pancreas: endoscopic ultrasound is superior to transabdominal sonography and computed tomography. Gastrointest Endosc 36:199–200

    Google Scholar 

  • Rösch T (1991) Endoscopic ultrasound in pancreatic tumor diagnosis. Gastrointest Endosc 37:347–352

    Article  PubMed  Google Scholar 

  • Rösch T (1992) Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography. Comparison with conventional sonography, computed tomography and angiography. Gastroenterology 102:188–199

    PubMed  Google Scholar 

  • Rösch T (2000) Endoscopic ultrasound criteria of vascular invasion in the staging of pancreatic head cancer: a blinded reevaluation of videotapes. Gastrointest Endosc 52:469–477

    Article  PubMed  Google Scholar 

  • Rösch T, Classen M (1992) Gastroenterologic endosonography. Textbook and atlas. Thieme Verlag, New York

    Google Scholar 

  • Snady H (1992) Endoscopic ultrasonography compared with computed tomography with ERCP in patients with obstructive jaundice or small peri-pancreatic mass. Gastrointest Endosc 38:27–34

    Article  PubMed  CAS  Google Scholar 

  • Soriano A (2004) Preoperative staging and tumor respectability assessment on pancreatic cancer: prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography. Am J Gastroenterol 99:492–501

    Article  PubMed  Google Scholar 

  • Tada M (2002) Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: clinikcal utility for diagnosis of pancreatic tumor. Am J Gastroenterol 97:2263–2270

    Article  PubMed  CAS  Google Scholar 

  • Wiersema MJ (1997) Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment. Gastrointest Endosc 112:1087–1095

    CAS  Google Scholar 

  • Wiersema MJ (2001) Accuracy of endoscopic ultrasonography in diagnosis and staging pancreatic carcinoma. Pancreatology 1:625–632

    Article  PubMed  CAS  Google Scholar 

  • Williams DB (1999) Endoscopic ultrasound guided fine needle aspiration biopsy: a large centre experience. Gut 44:720–726

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Yasuda K (1988) The diagnosis of pancreatic cancer by endoscopic ultrasonography. Gastrointest Endosc 34:1–8

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Angels Ginès .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ginès, A., Fernández-Esparrach, G., Ayuso, C. (2010). Endoscopic Ultrasonography in Pancreatic Tumors: When and Why?. In: Laghi, A. (eds) New Concepts in Diagnosis and Therapy of Pancreatic Adenocarcinoma. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_50

Download citation

  • DOI: https://doi.org/10.1007/174_2010_50

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85380-0

  • Online ISBN: 978-3-540-85381-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics