Abstract
Prenatal pathologies of the endocrine glands are generally rare, and reports in the literature about the use of fetal MRI for this purpose are still scarce. However, sonography and postnatal MR literature can help to assess the examination. For the pituitary gland, a T1w sequence is recommended to visualize the typical bright spot of the whole fetal gland. Possible pathologies include pituitary aplasia, duplication, ectopy, and transsphenoidal meningocele. The pineal gland is not demonstrable in fetal MRI. The thyroid gland is T1w hyperintense, and size can be measured, including screening for fetal goiter. In case of cervical teratoma or cystic hygroma, the position of the thyroid and trachea relative to the tumor should be assessed. The ovaries and undescended testes are usually not delineable. Fetal MRI is helpful in assessing ovarian cysts and possible complications, such as hemorrhage or torsion. In case of hydrocele, fetal MRI may be valuable in distinguishing simple from complex cases, the latter being associated with testicular torsion, inguinoscrotal hernia, or meconium periorchitis. For fetal MRI of the pancreas and adrenal glands, see Chapter 22.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Achiron R, Pinhas-Hamiel O, Zalel Y, Rotstein Z, Lipitz S (1998) Development of fetal male gender: prenatal sonographic measurement of the scrotum and evaluation of testicular descent. Ultrasound Obstet Gynecol 11:242–245
Agrawal P, Ogilvy-Stuart A, Lees C (2002) Intrauterine diagnosis and management of congenital goitrous hypothyroidism. Ultrasound Obstet Gynecol 19:501–505
Argyropoulou MI, Xydis V, Kiortsis DN, Pantou K, Zikou A, Efremidis SC, Andronikou S (2004) Pituitary gland signal in pre-term infants during the first year of life: an MRI study. Neuroradiology 46:1031–1035
Asa SL, Kovacs K, Laszlo FA, Domokos I, Ezrin C (1986) Human fetal adenohypophysis. Histologic and immunocytochemical analysis. Neuroendocrinology 43(3):308–316
Bernardes LS, Ruano R, Sapienza AD, Maganha CA, Zugaib M (2008) Nomograms of fetal thyroid measurements estimated by 2-dimensional sonography. J Clin Ultrasound 36:193–199
Birnholz JC (1983) Determination of fetal sex. N Engl J Med 309:942–944
Bouchard S, Johnson M, Flake A, Howell L, Myers L, Aszick N, Crombleholme T (2002) The EXIT procedure: experience and outcome in 31 cases. J Pediatr Surg 37:418–426
Castillo M (2005) Pituitary gland: development, normal appearances, and magnetic resonance imaging protocols. Top Magn Reson Imaging 16:259–268
Cervantes LF, Altman N, Medina L (2006) Pituitary aplasia. Radiology 241:936–938
Cicekcibasi A, Salbacak A, Seker M, Taner Z, Tuncer I, Buyukmumcu M (2007) Developmental variations and clinical importance of the fetal thyroid gland. A morphometric study. Saudi Med J 28(4):524–528
Colombo N, Berry I, Kucharczyk J, Kucharczyk W, de Groot J, Larson T, Norman D, Newton TH (1987) Posterior pituitary gland: appearance on MR images in normal and pathologic states. Radiology 165:481–485
Cox TD, Elster AD (1991) Normal pituitary gland: changes in shape, size, and signal intensity during the 1st year of life at MR imaging. Radiology 179:721–724
Crombleholme TM, Craigo SD, Garnel S, D´Alton ME (1997) Fetal ovarian cyst decompression to prevent torsion. J Pediatr Surg 32(10):1447–1449
De Penna GC, Pimenta MP, Drummond J, Sarquis M, Martins J, de Campos RC, Dias EP (2005) Duplication of the hypophysis associated with precocious puberty: presentation of two cases and review of pituitary embryogenesis. Arq Bras Endocrinol Metabol 49:323–327
Dietrich RB, Lis LE, Greensite FS, Pitt D (1995) Normal MR appearance of the pituitary gland in the first 2 years of life. Am J Neuroradiol 16:1413–1419
Fontaine J (1979) Multistep migration of calcitonin cell precursors during ontogeny of the mouse pharynx. Gen Comp Endocrinol 37:81–92
Frati A, Ducarme G, Vuillard E, Pecastaing A, Yver C, Pejoan H, Luton D (2008) Prenatal evaluation of a scrotal mass using a high-frequency probe in the diagnosis of inguinoscrotal hernia. Ultrasound Obstet Gynecol 32:949–950
Ganapathy R, Guven M, Sethna F, Vivekananda U, Thilaganathan B (2004) Natural history and outcome of prenatally diagnosed cystic hygroma. Prenat Diagn 24:965–968
Harnsberger H (2004) Diagnostic imaging: head & neck, 1st edn. Amyrsis, Salt Lake City
Herman A, Schvimer M, Tovbin J, Sandbank J, Bukovski I, Strauss S (2002) Antenatal sonographic diagnosis of testicular torsion. Ultrasound Obstet Gynecol 20:522–524
Hinrichsen K (1990) Humanembryologie: Lehrbuch und Atlas der vorgeburtlichen Entwicklung des Menschen. Springer, Berlin
Ho S, Metreweli C (1998) Normal fetal thyroid volume. Ultrasound Obstet Gynecol 11:118–122
Hörmann M, Brugger C, Ballasy C, Witzani L, Prayer D (2005) Fetal MRI of the urinary system. Eur J Radiol 57:303–311
Huismann T, Fischer U, Boltshauser E, Straube T, Gysin C (2005) Pituitary duplication and nasopharyngeal teratoma in a newborn: CT, MRI, US and correlative histopathological findings. Neuroradiology 47:558–561
Jabre A, Tabaddor R, Samaraweera R (2000) Transsphenoidal meningoencephalocele in adults. Surg Neurol 54:183–188
Karabulut N, Martin D, Yang M, Boyd B (2002) MR imaging findings in fetal goiter caused by maternal Graves disease. J Comput Assist Tomogr 26(4):538–540
Kathary N, Bulas D, Newman K, Schonberg R (2001) MRI imaging of fetal neck masses with airway compromise: utility in delivery planning. Pediatr Radiol 31:727–731
Kirchhoff M, Zimmermann B, Gundlach K, Henkel K (2006) Neonatales zervikales Teratom: Falldarstellung. Mund Kiefer Gesichtschir 10:259–262
Kitamura E, Miki Y, Kawai M, Itoh H, Yura S, Mori N, Sugimura K, Togashi K (2008) T1 signal intensity and height of the anterior pituitary in neonates: correlation with postnatal time. Am J Neuroradiol 29:1257–1260
Kollias S, Ball W, Prenger EC (1995) Review of the embryologic development of the pituitary gland and report of a hypophyseal duplication detected by MRI. Neuroradiology 37:3–12
Kondoh M, Miyazaki O, Imanishi Y, Hayakawa M, Aikyou M, Doi H (2004) Neonatal goiter with congenital thyroid dysfunction in two infants diagnosed by MRI. Pediatr Radiol 34:570–573
Koyuncu F, Tamay AG, Bugday S (2010) Intrauterine diagnosis and management of fetal goiter: a case report. J Clin Ultrasound 38(9):503–505
Kurokawa H, Fujisawa I, Nakano Y, Kimura H, Akagi K, Ikeda K, Uokawa K, Tanaka Y (1998) Posterior lobe of the pituitary gland: correlation between signal intensity on T1-weighted MR images and vasopressin concentration. Radiology 207:79–83
Lee HJ, Woo S, Kim J, Suh S (2000) Daughter cyst sign: a sonographic finding of ovarian cyst in neonates, infants, and young children. Am J Roentgenol 174:1013–1015
Lee MH, Choi HY, Sung YA, Lee JK (2001) High signal intensity of the posterior pituitary gland on T1-weighted MR images. Correlation with plasma vasopressin concentration to water deprivation. Acta Radiol 42:129–134
Manara R, Citton V, Rossetto M, Padoan A, D´Avella D (2009) Hypophyseal triplication: case report and embryologic considerations. AJNR Am J Neuroradiol 30(7):1328–1329
McEwing R, Hayward C, Furness M (2003) Foetal cystic abdominal masses. Australas Radiol 47:101–110
Mittermayer C, Brugger PC, Lee A, Horcher E, Hayde M, Bernaschek G, Prayer D (2005) Prenatal magnetic resonance imaging as a useful adjunctive to ultrasound-enhanced diagnosis in case of a giant foetal tumour of the neck. Ultraschall Med 26:46–50
Moore K, Persaud T (2008) The developing human: clinically oriented embryology, 8th edn. Saunders Elsevier, Philadelphia
Morton WR (1957) Duplication of the pituitary and stomatodaeal structures in a 38-week male infant. Arch Dis Child 32:135–141
Nath C, Oyelese Y, Yeo L, Chavez M, Kontopoulos V, Giannina G, Smulian J, Vintzileos A (2005) Picture of the month: three-dimensional sonography in the evaluation and management of fetal goiter. Ultrasound Obstet Gynecol 25:312–314
Pezerovic-Panijan R, Grbesa D, Baneka L, Jezek D, Relja Z, Puljiz M, Banek T, Cavciƒá J, Pezeroviƒá D (1999) Anthropological measurements of the skeleton and parathyroid glands growth during fetal development. Coll Antropol 23(2):737–744
Polak M, Van Vliet G (2010) Therapeutic approach to fetal thyroid disorders. Horm Res Paediatr 74:1–5
Pretorius D, Halsted M, Abels W, Catanzarie V, Kaplan G (1998) Hydroceles identified prenatally. J Ultrasound Med 17:49–52
Quarello E, Gorincour G, Merrot T, Boubli L, DÉrcole C (2003) The daughter cyst sign: a sonographic clue to the diagnosis of fetal ovarian cyst. Ultrasound Obstet Gynecol 22:433–434
Radaelli T, Cetin I, Zamperini P, Ferrazzi E, Pardi G (2002) Intrauterine growth of normal thyroid. Gynecol Endocrinol 16:427–430
Regev RH, Markovich O, Arnon S, Bauer S, Dolfin T, Litmanovitz I (2009) Meconium periorchitis: intrauterine diagnosis and neonatal outcome: case reports and review of the literature. J Perinatol 29:585–587
Sadler T, Drews U (2008) Medizinische Embryologie: Die normale menschliche Entwicklung und ihre Fehlbildungen, 11th edn. Georg Thieme Verlag, Stuttgart/New York
Schmook MT, Brugger PC, Weber M, Kasprian G, Nemec S, Krampl-Bettelheim E, Prayer D (2010) Forebrain development in fetal MRI: evaluation of anatomical landmarks before gestational week 27. Neuroradiology 52:495–504
Shinmoto H, Kashima K, Yuasa Y, Tanimoto A, Morikawa Y, Ishimoto H, Yoshimura Y, Hiramatsu K (2000) MR imaging of non-CNS fetal abnormalities: a pictorial essay. Radiographics 20:1227–1243
Shroff M, Blaser S, Jay V, Chitayat D, Armstrong D (2003) Basilar artery duplication associated with pituitary duplication: a new finding. Am J Neuroradiol 24:956–961
Slodki M, Respondek-Liberska M (2007) Fetal ovarian cysts – 420 cases from literature – metaanalysis 1984-2005. Ginekol Pol 78:324–328
Spampinato V, Castillo M (2005) Congenital pathology of the pituitary gland and parasellar region. Top Magn Reson Imaging 16:269–276
Suzuki N, Tsuchida Y, Takahashi A, Kuroiwa M, Ikeda H, Mohara J, Hatakeyama S, Koizumia T (1998) Prenatally diagnosed cystic lymphangioma in infants. J Pediatr Surg 33:1599–1604
Woodward P (2005) Diagnostic imaging: obstetrics, 1st edn. Amyrsis, Salt Lake City
Woodward P, Sohaey R, Kennedy A, Koeller K (2005) From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation. Radiographics 25:215–242
Zhu X, Lin CR, Prefontaine GG, Tollkuhn J, Rosenfeld MG (2005) Genetic control of pituitary development and hypopituitarism. Curr Opin Genet Dev 15:332–340
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Schmook, M.T. (2010). MRI of the Fetal Endocrine Glands. In: Prayer, D. (eds) Fetal MRI. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_115
Download citation
DOI: https://doi.org/10.1007/174_2010_115
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-73270-9
Online ISBN: 978-3-540-73271-6
eBook Packages: MedicineMedicine (R0)