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Inositide-Dependent Nuclear Signalling in Health and Disease

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Lipid Signaling in Human Diseases

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 259))

Abstract

Nuclear inositides have a specific subcellular distribution that is linked to specific functions; thus their regulation is fundamental both in health and disease. Emerging evidence shows that alterations in multiple inositide signalling pathways are involved in pathophysiology, not only in cancer but also in other diseases. Here, we give an overview of the main features of inositides in the cell, and we discuss their potential as new molecular therapeutic targets.

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Acknowledgments

This work was supported by grants from Intesa San Paolo Foundation and the Italian Ministry of University and Research – Projects of National Interest 2015.

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Author notes

  1. Matilde Y. Follo, Stefano Ratti, and Lucia Manzoli contributed equally to this work.

Authors and Affiliations

  1. Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy

    Matilde Y. Follo, Stefano Ratti, Lucia Manzoli, Giulia Ramazzotti, Irene Faenza, Roberta Fiume, Sara Mongiorgi & Lucio Cocco

  2. Korea Brain Research Institute, Daegu, Republic of Korea

    Pann Ghill Suh

  3. School of Life Sciences, UNIST, Ulsan, Republic of Korea

    Pann Ghill Suh

  4. Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA

    James A. McCubrey

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  1. Matilde Y. Follo
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  2. Stefano Ratti
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  3. Lucia Manzoli
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  4. Giulia Ramazzotti
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  5. Irene Faenza
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  7. Sara Mongiorgi
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  9. James A. McCubrey
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  10. Lucio Cocco
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Corresponding author

Correspondence to Lucio Cocco .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USA

    Julian Gomez-Cambronero

  2. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA

    Michael A. Frohman

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Follo, M.Y. et al. (2019). Inositide-Dependent Nuclear Signalling in Health and Disease. In: Gomez-Cambronero, J., Frohman, M. (eds) Lipid Signaling in Human Diseases. Handbook of Experimental Pharmacology, vol 259. Springer, Cham. https://doi.org/10.1007/164_2019_321

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