Abstract
With the approval of calcitonin gene-related peptide (CGRP) and CGRP receptor monoclonal antibodies by the Federal Drug Administration, a new era in the treatment of migraine patients is beginning. However, there are still many unknowns in terms of CGRP mechanisms of action that need to be elucidated to allow new advances in migraine therapies. CGRP has been studied both clinically and preclinically since its discovery. Here we review some of the preclinical data regarding CGRP in animal models of migraine.
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Acknowledgments
The authors thank members of the lab for their comments and support from Dept. Defense W81XWH-16-1-0071, W81XWH-16-1-0211; VA-ORD (RR&D) 1IO1RX002101; C6810-C and NIH NS075599.
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Wattiez, AS., Wang, M., Russo, A.F. (2018). CGRP in Animal Models of Migraine. In: Brain, S., Geppetti, P. (eds) Calcitonin Gene-Related Peptide (CGRP) Mechanisms. Handbook of Experimental Pharmacology, vol 255. Springer, Cham. https://doi.org/10.1007/164_2018_187
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