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Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology

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Lipid Signaling in Human Diseases

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 259))

Abstract

Inositol is the precursor for all inositol compounds and is essential for viability of eukaryotic cells. Numerous cellular processes and signaling functions are dependent on inositol compounds, and perturbation of their synthesis leads to a wide range of human diseases. Although considerable research has been directed at understanding the function of inositol compounds, especially phosphoinositides and inositol phosphates, a focus on regulatory and homeostatic mechanisms controlling inositol biosynthesis has been largely neglected. Consequently, little is known about how synthesis of inositol is regulated in human cells. Identifying physiological regulators of inositol synthesis and elucidating the molecular mechanisms that regulate inositol synthesis will contribute fundamental insight into cellular processes that are mediated by inositol compounds and will provide a foundation to understand numerous disease processes that result from perturbation of inositol homeostasis. In addition, elucidating the mechanisms of action of inositol-depleting drugs may suggest new strategies for the design of second-generation pharmaceuticals to treat psychiatric disorders and other illnesses.

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Acknowledgments

The Greenberg lab gratefully acknowledges support from grant R01 GM 125082 from the National Institutes of Health.

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Author notes

  1. Kendall C. Case, Michael Salsaa and Wenxi Yu contributed equally.

Authors and Affiliations

  1. Department of Biological Sciences, Wayne State University, Detroit, MI, USA

    Kendall C. Case, Michael Salsaa, Wenxi Yu & Miriam L. Greenberg

  2. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA

    Wenxi Yu

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  4. Miriam L. Greenberg
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Correspondence to Miriam L. Greenberg .

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  1. Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USA

    Julian Gomez-Cambronero

  2. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA

    Michael A. Frohman

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Case, K.C., Salsaa, M., Yu, W., Greenberg, M.L. (2018). Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology. In: Gomez-Cambronero, J., Frohman, M. (eds) Lipid Signaling in Human Diseases. Handbook of Experimental Pharmacology, vol 259. Springer, Cham. https://doi.org/10.1007/164_2018_181

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