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Brown Adipose Tissue pp 161–182Cite as

Role of cAMP and cGMP Signaling in Brown Fat

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 251))

Abstract

Cold-induced activation of brown adipose tissue (BAT) is mediated by norepinephrine and adenosine that are released during sympathetic nerve activation. Both signaling molecules induce an increase in intracellular levels of 3′,5′-cyclic adenosine monophosphate (cAMP) in murine and human BAT. In brown adipocytes, cAMP plays a central role, because it activates lipolysis, glucose uptake, and thermogenesis. Another well-studied intracellular second messenger is 3′,5′-cyclic guanosine monophosphate (cGMP), which closely resembles cAMP. Several studies have shown that intact cGMP signaling is essential for normal adipogenic differentiation and BAT-mediated thermogenesis in mice. This chapter highlights recent observations, demonstrating the physiological significance of cyclic nucleotide signaling in BAT as well as their potential to induce browning of white adipose tissue (WAT) in mice and humans.

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  1. LR-S and AS contributed equally to this review.

Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany

    Laia Reverte-Salisa, Abhishek Sanyal & Alexander Pfeifer

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  1. Laia Reverte-Salisa
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  2. Abhishek Sanyal
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  3. Alexander Pfeifer
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Correspondence to Alexander Pfeifer .

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  1. Institute of Pharmacology & Toxicology, University Hospital Bonn, University of Bonn, Bonn, Germany

    Alexander Pfeifer

  2. Institute of Molecular Nutritional Medicine, TU München, Freising, Bayern, Germany

    Martin Klingenspor

  3. Institute for Diabetes and Cancer IDC, Helmholtz Center München, Neuherberg, Germany

    Stephan Herzig

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Reverte-Salisa, L., Sanyal, A., Pfeifer, A. (2018). Role of cAMP and cGMP Signaling in Brown Fat. In: Pfeifer, A., Klingenspor, M., Herzig, S. (eds) Brown Adipose Tissue. Handbook of Experimental Pharmacology, vol 251. Springer, Cham. https://doi.org/10.1007/164_2018_117

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