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Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking

  • Chapter
Targeting Trafficking in Drug Development

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 245))

Abstract

The conserved oligomeric Golgi (COG) complex is an evolutionary conserved multi-subunit vesicle tethering complex essential for the majority of Golgi apparatus functions: protein and lipid glycosylation and protein sorting. COG is present in neuronal cells, but the repertoire of COG function in different Golgi-like compartments is an enigma. Defects in COG subunits cause alteration of Golgi morphology, protein trafficking, and glycosylation resulting in human congenital disorders of glycosylation (CDG) type II. In this review we summarize and critically analyze recent advances in the function of Golgi and Golgi-like compartments in neuronal cells and functions and dysfunctions of the COG complex and its partner proteins.

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Acknowledgments

We are very grateful to Tanner E. Brackett for the creation and design of Fig. 1. This work was supported by the NIH grants GM083144 and U54 GM105814 and by the Pilot grant from the Arkansas Biosciences Institute.

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Authors and Affiliations

  1. College of Medicine, Physiology and Biophysics, UAMS, Little Rock, AR, USA

    Leslie K. Climer & Vladimir V. Lupashin

  2. College of Medicine, Neurobiology and Developmental Sciences, UAMS, Little Rock, AR, USA

    Rachel D. Hendrix

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  1. Leslie K. Climer
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  2. Rachel D. Hendrix
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  3. Vladimir V. Lupashin
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Correspondence to Vladimir V. Lupashin .

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  1. Red de Apoyo a la Investigación, National Autonomous University of Mexico and Instituto Nacional de Ciencias, Médicas y Nutrición SZ, Mexico City, Mexico

    Alfredo Ulloa-Aguirre

  2. Dep of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, Auburn, Alabama, USA

    Ya-Xiong Tao

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Climer, L.K., Hendrix, R.D., Lupashin, V.V. (2017). Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking. In: Ulloa-Aguirre, A., Tao, YX. (eds) Targeting Trafficking in Drug Development. Handbook of Experimental Pharmacology, vol 245. Springer, Cham. https://doi.org/10.1007/164_2017_65

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