Skip to main content
SpringerLink
Log in

Histamine Release from Mast Cells and Basophils

  • Chapter
  • First Online:
Histamine and Histamine Receptors in Health and Disease

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 241))

Abstract

Mast cells and basophils represent the most relevant source of histamine in the immune system. Histamine is stored in cytoplasmic granules along with other amines (e.g., serotonin), proteases, proteoglycans, cytokines/chemokines, and angiogenic factors and rapidly released upon triggering with a variety of stimuli. Moreover, mast cell and basophil histamine release is regulated by several activating and inhibitory receptors. The engagement of different receptors can trigger different modalities of histamine release and degranulation. Histamine released from mast cells and basophils exerts its biological activities by activating four G protein-coupled receptors, namely H1R, H2R, H3R (expressed mainly in the brain), and the recently identified H4R. While H1R and H2R activation accounts mainly for some mast cell- and basophil-mediated allergic disorders, the selective expression of H4R on immune cells is uncovering new roles for histamine (possibly derived from mast cells and basophils) in allergic, inflammatory, and autoimmune disorders. Thus, the in-depth knowledge of mast cell and basophil histamine release and its biologic effects is poised to uncover new therapeutic avenues for a wide spectrum of disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akahoshi M, Song CH, Piliponsky AM, Metz M, Guzzetta A, Abrink M, Schlenner SM, Feyerabend TB, Rodewald HR, Pejler G, Tsai M, Galli SJ (2011) Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121:4180–4191

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi R (2014) Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C epsilon-dependent aldehyde dehydrogenase type-2 activation. J Pharmacol Exp Ther 349:508–517

    Article  PubMed  PubMed Central  Google Scholar 

  • Artuc M, Guhl S, Babina M, Unger T, Steckelings UM, Zuberbier T (2011) Mast cell-derived TNF-alpha and histamine modify IL-6 and IL-8 expression and release from cutaneous tumor cells. Exp Dermatol 20:1020–1022

    Article  CAS  PubMed  Google Scholar 

  • Bachelet I, Munitz A, Moretta A, Moretta L, Levi-Schaffer F (2005) The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J Immunol 175:7989–7995

    Article  CAS  PubMed  Google Scholar 

  • Bachelet I, Munitz A, Levi-Schaffer F (2006) Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J Allergy Clin Immunol 117:1314–1320

    Article  CAS  PubMed  Google Scholar 

  • Bachelet I, Munitz A, Berent-Maoz B, Mankuta D, Levi-Schaffer F (2008) Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a. J Immunol 180:6064–6069

    Article  CAS  PubMed  Google Scholar 

  • Best CH, Dale HH, Dudley HW, Thorpe WV (1927) The nature of the vaso-dilator constituents of certain tissue extracts. J Physiol 62:397–417

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Borriello F, Granata F, Marone G (2014a) Basophils and skin disorders. J Invest Dermatol 134:1202–1210

    Article  CAS  PubMed  Google Scholar 

  • Borriello F, Granata F, Varricchi G, Genovese A, Triggiani M, Marone G (2014b) Immunopharmacological modulation of mast cells. Curr Opin Pharmacol 17:45–57

    Article  CAS  PubMed  Google Scholar 

  • Borriello F, Longo M, Spinelli R, Pecoraro A, Granata F, Staiano RI, Loffredo S, Spadaro G, Beguinot F, Schroeder J, Marone G (2015) IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes. Eur J Immunol 45:2042–2051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brune M, Hansson M, Mellqvist UH, Hermodsson S, Hellstrand K (1996) NK cell-mediated killing of AML blasts: role of histamine, monocytes and reactive oxygen metabolites. Eur J Haematol 57:312–319

    Article  CAS  PubMed  Google Scholar 

  • Bryce PJ, Mathias CB, Harrison KL, Watanabe T, Geha RS, Oettgen HC (2006) The H1 histamine receptor regulates allergic lung responses. J Clin Invest 116:1624–1632

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Buckland KF, Williams TJ, Conroy DM (2003) Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol 140:1117–1127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Buhring HJ, Streble A, Valent P (2004) The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int Arch Allergy Immunol 133:317–329

    Article  PubMed  CAS  Google Scholar 

  • Burde R, Seifert R, Buschauer A, Schultz G (1989) Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors. Naunyn Schmiedeberg’s Arch Pharmacol 340:671–678

    Article  CAS  Google Scholar 

  • Chan CY, John ALS, Abraham SN (2012) Plasticity in mast cell responses during bacterial infections. Curr Opin Microbiol 15:78–84

    Article  PubMed  Google Scholar 

  • Clark RA, Gallin JI, Kaplan AP (1975) The selective eosinophil chemotactic activity of histamine. J Exp Med 142:1462–1476

    Article  CAS  PubMed  Google Scholar 

  • Clark GJ, Ju X, Tate C, Hart DN (2009) The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. Trends Immunol 30:209–217

    Article  CAS  PubMed  Google Scholar 

  • Cohen RW, Rosenstreich DL (1986) Discrimination between urticaria-prone and other allergic patients by intradermal skin testing with codeine. J Allergy Clin Immunol 77:802–807

    Article  CAS  PubMed  Google Scholar 

  • Cowden JM, Zhang M, Dunford PJ, Thurmond RL (2010) The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation. J Invest Dermatol 130:1023–1033

    Article  CAS  PubMed  Google Scholar 

  • Daeron M, Jaeger S, Pasquier LD, Vivier E (2008) Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev 224:11–43

    Article  CAS  PubMed  Google Scholar 

  • Dale HH, Laidlaw PP (1910) The physiological action of beta-iminazolylethylamine. J Physiol 41:318–344

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Damaj BB, Becerra CB, Esber HJ, Wen Y, Maghazachi AA (2007) Functional expression of H4 histamine receptor in human natural killer cells, monocytes, and dendritic cells. J Immunol 179:7907–7915

    Article  CAS  PubMed  Google Scholar 

  • de Paulis A, Prevete N, Fiorentino I, Rossi FW, Staibano S, Montuori N, Ragno P, Longobardi A, Liccardo B, Genovese A, Ribatti D, Walls AF, Marone G (2006) Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J Immunol 177:7322–7331

    Article  PubMed  Google Scholar 

  • Detoraki A, Staiano RI, Granata F, Giannattasio G, Prevete N, de Paulis A, Ribatti D, Genovese A, Triggiani M, Marone G (2009) Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol 123:1142–1149, 1149.e1–5

    Google Scholar 

  • Eberle JU, Voehringer D (2016) Role of basophils in protective immunity to parasitic infections. Semin Immunopathol 38:605–613

    Article  PubMed  Google Scholar 

  • Ezeamuzie CI, Philips E (2000) Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation. Br J Pharmacol 131:482–488

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feldberg W, Kellaway CH (1937) Liberation of histamine from the perfused lung by snake venoms. J Physiol 90:257–279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feldberg W, Keogh EV (1937) Liberation of histamine from the perfused lung by staphylococcal toxin. J Physiol 90:280–287

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feldberg W, O’Connor WJ (1937) The liberation of histamine from the perfused lung by peptone. J Physiol 90:288–295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Findlay SR, Lichtenstein LM (1980) Basophil “releasability” in patients with asthma. Am Rev Respir Dis 122:53–59

    CAS  PubMed  Google Scholar 

  • Frei R, Ferstl R, Konieczna P, Ziegler M, Simon T, Rugeles TM, Mailand S, Watanabe T, Lauener R, Akdis CA, O’Mahony L (2013) Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol 132:194–204

    Article  CAS  PubMed  Google Scholar 

  • Galli SJ, Tsai M (2012) IgE and mast cells in allergic disease. Nat Med 18:693–704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gantner F, Sakai K, Tusche MW, Cruikshank WW, Center DM, Bacon KB (2002) Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. J Pharmacol Exp Ther 303:300–307

    Article  CAS  PubMed  Google Scholar 

  • Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ (2016) Different activation signals induce distinct mast cell degranulation strategies. J Clin Invest 126:3981–3998

    Article  PubMed  PubMed Central  Google Scholar 

  • Genovese A, Borgia G, Bjorck L, Petraroli A, de Paulis A, Piazza M, Marone G (2003) Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human Fc epsilon RI+ cells through interaction with the kappa light chains of IgE. J Immunol 170:1854–1861

    Article  CAS  PubMed  Google Scholar 

  • Gibbs BF, Sabato V, Bridts CH, Ebo DG, Ben-Zimra M, Levi-Schaffer F (2012) Expressions and inhibitory functions of CD300a receptors on purified human basophils. Exp Dermatol 21:884–886

    Article  CAS  PubMed  Google Scholar 

  • Godot V, Arock M, Garcia G, Capel F, Flys C, Dy M, Emilie D, Humbert M (2007) H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12. J Allergy Clin Immunol 120:827–834

    Article  CAS  PubMed  Google Scholar 

  • Graham HT, Lowry OH, Wheelwright F, Lenz MA, Parish HH Jr (1955) Distribution of histamine among leukocytes and platelets. Blood 10:467–481

    CAS  PubMed  Google Scholar 

  • Grant JA, Dupree E, Goldman AS, Schultz DR, Jackson AL (1975) Complement-mediated release of histamine from human leukocytes. J Immunol 114:1101–1106

    CAS  PubMed  Google Scholar 

  • Gutzmer R, Mommert S, Gschwandtner M, Zwingmann K, Stark H, Werfel T (2009) The histamine H4 receptor is functionally expressed on T(H)2 cells. J Allergy Clin Immunol 123:619–625

    Article  CAS  PubMed  Google Scholar 

  • Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, Witte ON, Kawakami T (1998) Involvement of Bruton’s tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. J Exp Med 187:1235–1247

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Havard S, Scola AM, Kay LJ, Ishmael SS, MacGlashan DW Jr, Peachell PT (2011) Characterization of syk expression in human lung mast cells: relationship with function. Clin Exp Allergy 41:378–388

    Article  CAS  PubMed  Google Scholar 

  • Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP (2003) Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. J Pharmacol Exp Ther 305:1212–1221

    Article  CAS  PubMed  Google Scholar 

  • Huber M, Gibbs BF (2015) SHIP1 and the negative control of mast cell/basophil activation by supra-optimal antigen concentrations. Mol Immunol 63:32–37

    Article  CAS  PubMed  Google Scholar 

  • Imamura M, Poli E, Omoniyi AT, Levi R (1994) Unmasking of activated histamine H3-receptors in myocardial ischemia: their role as regulators of exocytotic norepinephrine release. J Pharmacol Exp Ther 271:1259–1266

    CAS  PubMed  Google Scholar 

  • Imamura M, Seyedi N, Lander HM, Levi R (1995) Functional identification of histamine H3-receptors in the human heart. Circ Res 77:206–210

    Article  CAS  PubMed  Google Scholar 

  • Imamura M, Lander HM, Levi R (1996) Activation of histamine H3-receptors inhibits carrier-mediated norepinephrine release during protracted myocardial ischemia. Comparison with adenosine A1-receptors and alpha2-adrenoceptors. Circ Res 78:475–481

    Article  CAS  PubMed  Google Scholar 

  • Inoue I, Taniuchi I, Kitamura D, Jenkins NA, Gilbert DJ, Copeland NG, Watanabe T (1996) Characteristics of the mouse genomic histamine H1 receptor gene. Genomics 36:178–181

    Article  CAS  PubMed  Google Scholar 

  • Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J (2012) The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity 37:827–839

    Article  CAS  PubMed  Google Scholar 

  • Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J (2014) Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcepsilonRI-mediated mast cell activation. J Allergy Clin Immunol 133:270–273.e1–7

    Article  CAS  PubMed  Google Scholar 

  • Jones H, Hargrove L, Kennedy L, Meng F, Graf-Eaton A, Owens J, Alpini G, Johnson C, Bernuzzi F, Demieville J, DeMorrow S, Invernizzi P, Francis H (2016) Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2(−/−) mice. Hepatology 64:1202–1216

    Article  CAS  PubMed  Google Scholar 

  • Jutel M, Watanabe T, Klunker S, Akdis M, Thomet OA, Malolepszy J, Zak-Nejmark T, Koga R, Kobayashi T, Blaser K, Akdis CA (2001) Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 413:420–425

    Article  CAS  PubMed  Google Scholar 

  • Karasuyama H, Mukai K, Obata K, Tsujimura Y, Wada T (2011) Nonredundant roles of basophils in immunity. Annu Rev Immunol 29:45–69

    Article  CAS  PubMed  Google Scholar 

  • Karra L, Levi-Schaffer F (2011) Down-regulation of mast cell responses through ITIM containing inhibitory receptors. Adv Exp Med Biol 716:143–159

    Article  CAS  PubMed  Google Scholar 

  • Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H (2011) G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. Eur J Pharmacol 668:299–304

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kawakami T, Kashiwakura J, Kawakami Y (2014) Histamine-releasing factor and immunoglobulins in asthma and allergy. Allergy Asthma Immunol Res 6:6–12

    Article  CAS  PubMed  Google Scholar 

  • Kepley CL, Youssef L, Andrews RP, Wilson BS, Oliver JM (1999) Syk deficiency in nonreleaser basophils. J Allergy Clin Immunol 104:279–284

    Article  CAS  PubMed  Google Scholar 

  • Kern F, Lichtenstein LM (1976) Defective histamine release in chronic urticaria. J Clin Invest 57:1369–1377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kiwamoto T, Kawasaki N, Paulson JC, Bochner BS (2012) Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions. Pharmacol Ther 135:327–336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Knol EF, Mul FP, Jansen H, Calafat J, Roos D (1991) Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 88:328–338

    Article  CAS  PubMed  Google Scholar 

  • Kobayashi T, Tonai S, Ishihara Y, Koga R, Okabe S, Watanabe T (2000) Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J Clin Invest 105:1741–1749

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kuehn HS, Swindle EJ, Kim MS, Beaven MA, Metcalfe DD, Gilfillan AM (2008) The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. J Immunol 181:7706–7712

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumagai H, Oki T, Tamitsu K, Feng SZ, Ono M, Nakajima H, Bao YC, Kawakami Y, Nagayoshi K, Copeland NG, Gilbert DJ, Jenkins NA, Kawakami T, Kitamura T (2003) Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun 307:719–729

    Article  CAS  PubMed  Google Scholar 

  • Lavens-Phillips SE, MacGlashan DW Jr (2000) The tyrosine kinases p53/56lyn and p72syk are differentially expressed at the protein level but not at the messenger RNA level in nonreleasing human basophils. Am J Respir Cell Mol Biol 23:566–571

    Article  CAS  PubMed  Google Scholar 

  • Leite-de-Moraes MC, Diem S, Michel ML, Ohtsu H, Thurmond RL, Schneider E, Dy M (2009) Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells. J Immunol 182:1233–1236

    Article  CAS  PubMed  Google Scholar 

  • Lewis T, Grant RT (1924) Vascular reactions of the skin to injury. Part 11. The liberation of histamine-like substance in the injured skin, the underlying cause of factitious urticaria and of wheals produced by burning: and observations upon the nervous control of certain skin reactions. Heart 11:209–265

    CAS  Google Scholar 

  • Lichtenstein LM, Gillespie E (1973) Inhibition of histamine release by histamine controlled by H2 receptor. Nature 244:287–288

    Article  CAS  PubMed  Google Scholar 

  • Lieberman P, Garvey LH (2016) Mast cells and anaphylaxis. Curr Allergy Asthma Rep 16:20

    Article  PubMed  CAS  Google Scholar 

  • Liu WL (2014) Histamine H4 receptor antagonists for the treatment of inflammatory disorders. Drug Discov Today 19:1222–1225

    Article  CAS  PubMed  Google Scholar 

  • MacGlashan DW Jr (2007) Relationship between spleen tyrosine kinase and phosphatidylinositol 5′ phosphatase expression and secretion from human basophils in the general population. J Allergy Clin Immunol 119:626–633

    Article  CAS  PubMed  Google Scholar 

  • MacGlashan D Jr (2010) Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes. Clin Exp Allergy 40:1365–1377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • MacGlashan D Jr (2012) Marked differences in the signaling requirements for expression of CD203c and CD11b versus CD63 expression and histamine release in human basophils. Int Arch Allergy Immunol 159:243–252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • MacGlashan D Jr, Honigberg LA, Smith A, Buggy J, Schroeder JT (2011) Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton’s tyrosine kinase, Btk, inhibitor. Int Immunopharmacol 11:475–479

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Macglashan D Jr, Moore G, Muchhal U (2014) Regulation of IgE-mediated signalling in human basophils by CD32b and its role in syk down-regulation: basic mechanisms in allergic disease. Clin Exp Allergy 44:713–723

    Article  CAS  PubMed  Google Scholar 

  • Marichal T, Tsai M, Galli SJ (2013a) Mast cells: potential positive and negative roles in tumor biology. Cancer Immunol Res 1:269–279

    Article  CAS  PubMed  Google Scholar 

  • Marichal T, Starkl P, Reber LL, Kalesnikoff J, Oettgen HC, Tsai M, Metz M, Galli SJ (2013b) A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity 39:963–975

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marone G, Florio G, Petraroli A, de Paulis A (2001) Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection. J Allergy Clin Immunol 107:22–30

    Article  CAS  PubMed  Google Scholar 

  • Marone G, Triggiani M, Genovese A, De Paulis A (2005) Role of human mast cells and basophils in bronchial asthma. Adv Immunol 88:97–160

    Article  CAS  PubMed  Google Scholar 

  • Marone G, Borriello F, Varricchi G, Genovese A, Granata F (2014) Basophils: historical reflections and perspectives. Chem Immunol Allergy 100:172–192

    Article  PubMed  Google Scholar 

  • Masini E, Blandina P, Brunelleschi S, Mannaioni PF (1982) Evidence for H2-receptor-mediated inhibition of histamine release from isolated rat mast cells. Agents Actions 12:85–88

    Article  CAS  PubMed  Google Scholar 

  • Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ (2004) Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432:512–516

    Article  CAS  PubMed  Google Scholar 

  • May CD (1976) High spontaneous release of histamine in vitro from leukocytes of persons hypersensitive to food. J Allergy Clin Immunol 58:432–437

    Article  CAS  PubMed  Google Scholar 

  • Mazzoni A, Leifer CA, Mullen GE, Kennedy MN, Klinman DM, Segal DM (2003) Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells. J Immunol 170:2269–2273

    Article  CAS  PubMed  Google Scholar 

  • McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X (2015) Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature 519:237–241

    Article  CAS  PubMed  Google Scholar 

  • Meiler F, Zumkehr J, Klunker S, Ruckert B, Akdis CA, Akdis M (2008) In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 205:2887–2898

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Melillo RM, Guarino V, Avilla E, Galdiero MR, Liotti F, Prevete N, Rossi FW, Basolo F, Ugolini C, de Paulis A, Santoro M, Marone G (2010) Mast cells have a protumorigenic role in human thyroid cancer. Oncogene 29:6203–6215

    Article  CAS  PubMed  Google Scholar 

  • Metz M, Piliponsky AM, Chen CC, Lammel V, Abrink M, Pejler G, Tsai M, Galli SJ (2006) Mast cells can enhance resistance to snake and honeybee venoms. Science 313:526–530

    Article  CAS  PubMed  Google Scholar 

  • Meyer J, Gorbach AM, Liu WM, Medic N, Young M, Nelson C, Arceo S, Desai A, Metcalfe DD, Komarow HD (2013) Mast cell dependent vascular changes associated with an acute response to cold immersion in primary contact urticaria. PLoS One 8:e56773

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mobarakeh JI, Sakurada S, Katsuyama S, Kutsuwa M, Kuramasu A, Lin ZY, Watanabe T, Hashimoto Y, Watanabe T, Yanai K (2000) Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice. Eur J Pharmacol 391:81–89

    Article  CAS  PubMed  Google Scholar 

  • Mobarakeh JI, Sakurada S, Hayashi T, Orito T, Okuyama K, Sakurada T, Kuramasu A, Watanabe T, Watanabe T, Yanai K (2002) Enhanced antinociception by intrathecally-administered morphine in histamine H1 receptor gene knockout mice. Neuropharmacology 42:1079–1088

    Article  CAS  PubMed  Google Scholar 

  • Mommert S, Kleiner S, Gehring M, Eiz-Vesper B, Stark H, Gutzmer R, Werfel T, Raap U (2016) Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy 71:1264–1273

    Article  CAS  PubMed  Google Scholar 

  • Moon TC, Befus AD, Kulka M (2014) Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol 5:569

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW (2007) Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol 178:8081–8089

    Article  CAS  PubMed  Google Scholar 

  • Novak N, Mete N, Bussmann C, Maintz L, Bieber T, Akdis M, Zumkehr J, Jutel M, Akdis C (2012) Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2. J Allergy Clin Immunol 130:1153–1158.e2

    Article  CAS  PubMed  Google Scholar 

  • O’Mahony L, Akdis M, Akdis CA (2011) Regulation of the immune response and inflammation by histamine and histamine receptors. J Allergy Clin Immunol 128:1153–1162

    Article  PubMed  CAS  Google Scholar 

  • O’Reilly M, Alpert R, Jenkinson S, Gladue RP, Foo S, Trim S, Peter B, Trevethick M, Fidock M (2002) Identification of a histamine H4 receptor on human eosinophils – role in eosinophil chemotaxis. J Recept Signal Transduct Res 22:431–448

    Article  PubMed  CAS  Google Scholar 

  • Panula P, Chazot PL, Cowart M, Gutzmer R, Leurs R, Liu WL, Stark H, Thurmond RL, Haas HL (2015) International Union of Basic and Clinical Pharmacology. XCVIII. Histamine receptors. Pharmacol Rev 67:601–655

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patella V, Florio G, Petraroli A, Marone G (2000) HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. J Immunol 164:589–595

    Article  CAS  PubMed  Google Scholar 

  • Popielski L (1920) β-Imidazolylathylamin und die Organextrakte Erster Teil: b-Imidazolylathylamin als mechtiger Errezer der Magendrucken. Pfluegers Arch 178:214–236

    Article  CAS  Google Scholar 

  • Riley JF, West GB (1952) Histamine in tissue mast cells. J Physiol 117:72P–73P

    CAS  PubMed  Google Scholar 

  • Riley JF, West GB (1953) The presence of histamine in tissue mast cells. J Physiol 120:528–537

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rivellese F, Suurmond J, de Paulis A, Marone G, Huizinga TW, Toes RE (2014) IgE and IL-33-mediated triggering of human basophils inhibits TLR4-induced monocyte activation. Eur J Immunol 44:3045–3055

    Article  CAS  PubMed  Google Scholar 

  • Rivellese F, Suurmond J, Habets K, Dorjee AL, Ramamoorthi N, Townsend MJ, de Paulis A, Marone G, Huizinga TW, Pitzalis C, Toes RE (2015) Ability of interleukin-33- and immune complex-triggered activation of human mast cells to down-regulate monocyte-mediated immune responses. Arthritis Rheumatol 67:2343–2353

    Article  CAS  PubMed  Google Scholar 

  • Rizk A, Curley J, Robertson J, Raber J (2004) Anxiety and cognition in histamine H3 receptor−/− mice. Eur J Neurosci 19:1992–1996

    Article  PubMed  Google Scholar 

  • Rossbach K, Schaper K, Kloth C, Gutzmer R, Werfel T, Kietzmann M, Baumer W (2016) Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis. Allergy 71:189–197

    Article  CAS  PubMed  Google Scholar 

  • Sabato V, Verweij MM, Bridts CH, Levi-Schaffer F, Gibbs BF, De Clerck LS, Schiavino D, Ebo DG (2012) CD300a is expressed on human basophils and seems to inhibit IgE/FcepsilonRI-dependent anaphylactic degranulation. Cytometry B Clin Cytom 82:132–138

    Article  PubMed  CAS  Google Scholar 

  • Sabato V, Boita M, Shubber S, Bridts CH, Shibuya A, De Clerck LS, Falcone FH, Ebo DG (2014) Mechanism of phosphatidylserine inhibition of IgE/FcepsilonRI-dependent anaphylactic human basophil degranulation via CD300a. J Allergy Clin Immunol 134:734–737.e3

    Article  CAS  PubMed  Google Scholar 

  • Sadek B, Saad A, Sadeq A, Jalal F, Stark H (2016) Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases. Behav Brain Res 312:415–430

    Article  CAS  PubMed  Google Scholar 

  • Saini SS (2009) Basophil responsiveness in chronic urticaria. Curr Allergy Asthma Rep 9:286–290

    Article  CAS  PubMed  Google Scholar 

  • Sampson HA, Broadbent KR, Bernhisel-Broadbent J (1989) Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. N Engl J Med 321:228–232

    Article  CAS  PubMed  Google Scholar 

  • Schafer B, Piliponsky AM, Oka T, Song CH, Gerard NP, Gerard C, Tsai M, Kalesnikoff J, Galli SJ (2013) Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice. J Allergy Clin Immunol 131:541–548.e1–9

    Article  CAS  PubMed  Google Scholar 

  • Schneider LA, Schlenner SM, Feyerabend TB, Wunderlin M, Rodewald HR (2007) Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin. J Exp Med 204:2629–2639

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schroeder JT (2011) Basophils: emerging roles in the pathogenesis of allergic disease. Immunol Rev 242:144–160

    Article  CAS  PubMed  Google Scholar 

  • Schroeder JT, Bieneman AP, Chichester KL, Keet CA, Hamilton RG, MacGlashan DW Jr, Wood R, Frischmeyer-Guerrerio PA (2013) Spontaneous basophil responses in food-allergic children are transferable by plasma and are IgE-dependent. J Allergy Clin Immunol 132:1428–1431

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Seifert R, Strasser A, Schneider EH, Neumann D, Dove S, Buschauer A (2013) Molecular and cellular analysis of human histamine receptor subtypes. Trends Pharmacol Sci 34:33–58

    Article  CAS  PubMed  Google Scholar 

  • Shiraishi Y, Jia Y, Domenico J, Joetham A, Karasuyama H, Takeda K, Gelfand EW (2013) Sequential engagement of FcepsilonRI on mast cells and basophil histamine H(4) receptor and FcepsilonRI in allergic rhinitis. J Immunol 190:539–548

    Article  CAS  PubMed  Google Scholar 

  • Siraganian RP, Hook WA (1977) Mechanism of histamine release by formyl methionine-containing peptides. J Immunol 119:2078–2083

    CAS  PubMed  Google Scholar 

  • Stone KD, Prussin C, Metcalfe DD (2010) IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 125:S73–S80

    Article  PubMed  PubMed Central  Google Scholar 

  • Subramanian H, Gupta K, Guo Q, Price R, Ali H (2011) Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. J Biol Chem 286:44739–44749

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Subramanian H, Gupta K, Lee D, Bayir AK, Ahn H, Ali H (2013) Beta-defensins activate human mast cells via Mas-related gene X2. J Immunol 191:345–352

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Takahashi K, Suwa H, Ishikawa T, Kotani H (2002) Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J Clin Invest 110:1791–1799

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Takeshita K, Sakai K, Bacon KB, Gantner F (2003) Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo. J Pharmacol Exp Ther 307:1072–1078

    Article  CAS  PubMed  Google Scholar 

  • Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther 309:404–413

    Article  CAS  PubMed  Google Scholar 

  • Toyota H, Dugovic C, Koehl M, Laposky AD, Weber C, Ngo K, Wu Y, Lee DH, Yanai K, Sakurai E, Watanabe T, Liu C, Chen J, Barbier AJ, Turek FW, Fung-Leung WP, Lovenberg TW (2002) Behavioral characterization of mice lacking histamine H(3) receptors. Mol Pharmacol 62:389–397

    Article  CAS  PubMed  Google Scholar 

  • Triggiani M, Gentile M, Secondo A, Granata F, Oriente A, Taglialatela M, Annunziato L, Marone G (2001) Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. J Immunol 166:4083–4091

    Article  CAS  PubMed  Google Scholar 

  • Triggiani M, Petraroli A, Loffredo S, Frattini A, Granata F, Morabito P, Staiano RI, Secondo A, Annunziato L, Marone G (2007) Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor. J Allergy Clin Immunol 119:472–481

    Article  CAS  PubMed  Google Scholar 

  • Truta-Feles K, Lagadari M, Lehmann K, Berod L, Cubillos S, Piehler S, Herouy Y, Barz D, Kamradt T, Maghazachi A, Norgauer J (2010) Histamine modulates gammadelta-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways. Br J Pharmacol 161:1291–1300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Varricchi G, Galdiero MR, Marone G, Granata F, Borriello F, Marone G (2016) Controversial role of mast cells in skin cancers. Exp Dermatol 26:11–17

    Google Scholar 

  • Visciano C, Liotti F, Prevete N, Cali G, Franco R, Collina F, de Paulis A, Marone G, Santoro M, Melillo RM (2015) Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway. Oncogene 34:5175–5186

    Article  CAS  PubMed  Google Scholar 

  • Voehringer D (2012) Basophil modulation by cytokine instruction. Eur J Immunol 42:2544–2550

    Article  CAS  PubMed  Google Scholar 

  • Vonakis BM, Saini SS (2008) Syk-deficient basophils from donors with chronic idiopathic urticaria exhibit a spectrum of releasability. J Allergy Clin Immunol 121:262–264

    Article  CAS  PubMed  Google Scholar 

  • Vonakis BM, Vasagar K, Gibbons SP Jr, Gober L, Sterba PM, Chang H, Saini SS (2007) Basophil FcepsilonRI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria. J Allergy Clin Immunol 119:441–448

    Article  CAS  PubMed  Google Scholar 

  • Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuyama H (2010) Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120:2867–2875

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wakahara K, Baba N, Van VQ, Begin P, Rubio M, Ferraro P, Panzini B, Wassef R, Lahaie R, Caussignac Y, Tamaz R, Richard C, Soucy G, Delespesse G, Sarfati M (2012) Human basophils interact with memory T cells to augment Th17 responses. Blood 120:4761–4771

    Article  CAS  PubMed  Google Scholar 

  • Wang M, Han J, Domenico J, Shin YS, Jia Y, Gelfand EW (2016) Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function. Allergy 71:1561–1574

    Article  CAS  PubMed  Google Scholar 

  • Wechsler JB, Schroeder HA, Byrne AJ, Chien KB, Bryce PJ (2013) Anaphylactic responses to histamine in mice utilize both histamine receptors 1 and 2. Allergy 68:1338–1340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yanai K, Son LZ, Endou M, Sakurai E, Nakagawasai O, Tadano T, Kisara K, Inoue I, Watanabe T, Watanabe T (1998) Behavioural characterization and amounts of brain monoamines and their metabolites in mice lacking histamine H1 receptors. Neuroscience 87:479–487

    Article  CAS  PubMed  Google Scholar 

  • Yano H, Wershil BK, Arizono N, Galli SJ (1989) Substance P-induced augmentation of cutaneous vascular permeability and granulocyte infiltration in mice is mast cell dependent. J Clin Invest 84:1276–1286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yokoi H, Choi OH, Hubbard W, Lee HS, Canning BJ, Lee HH, Ryu SD, von Gunten S, Bickel CA, Hudson SA, Macglashan DW Jr, Bochner BS (2008) Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. J Allergy Clin Immunol 121:499–505.e1

    Article  CAS  PubMed  Google Scholar 

  • Zhu D, Kepley CL, Zhang M, Zhang K, Saxon A (2002) A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat Med 8:518–521

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

This work was supported in part by grants from Regione Campania CISI-Lab Project, CRèME Project, and TIMING Project (G.M.). G.M. is the recipient of the Ferdinando Palasciano Award 2016.

Author information

Authors and Affiliations

  1. Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), School of Medicine, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy

    Francesco Borriello, Raffaella Iannone & Gianni Marone

  2. Division of Infectious Diseases, Department of Medicine, Boston Children’s Hospital, Boston, MA, 02115, USA

    Francesco Borriello

  3. Institute of Experimental Endocrinology and Oncology “Gaetano Salvatore” (IEOS), National Research Council (CNR), Naples, Italy

    Gianni Marone

Authors
  1. Francesco Borriello
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Raffaella Iannone
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gianni Marone
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gianni Marone .

Editor information

Editors and Affiliations

  1. Department of Molecular and Medical Pharmacology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Yuichi Hattori

  2. Institute of Pharmacology, Medical School of Hannover, Hannover, Germany

    Roland Seifert

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Borriello, F., Iannone, R., Marone, G. (2017). Histamine Release from Mast Cells and Basophils. In: Hattori, Y., Seifert, R. (eds) Histamine and Histamine Receptors in Health and Disease. Handbook of Experimental Pharmacology, vol 241. Springer, Cham. https://doi.org/10.1007/164_2017_18

Download citation

Publish with us

Policies and ethics

Search

Navigation