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Heart Failure pp 423–445Cite as

Noncoding RNAs in Heart Failure

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 243))

Abstract

Heart failure is a major contributor to the healthcare burden and mortality worldwide. Current treatment strategies are able to slow down the transition of healthy heart into the failing one; nevertheless better understanding of the complex genetic regulation of maladaptive remodeling in the failing heart is essential for new drug discovery. Noncoding RNAs are key epigenetic regulators of cardiac gene expression and thus significantly influence cardiac homeostasis and functions.

In this chapter we will discuss characteristics of noncoding RNAs, especially miRNAs, long noncoding RNAs, and circular RNAs, and review recent evidences proving their profound involvement during different stages of heart failure progression. Several open questions still prevent the extensive use of noncoding RNA-modulating therapies in clinics; yet they are becoming an attractive target to define novel regulatory mechanisms in the heart. In-depth study of their interaction with gene networks will refine our current view of heart failure and revolutionize the drug development in coming years.

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Authors and Affiliations

  1. Institute of Molecular and Translational Therapeutic Strategies, IFBTx, Hannover Medical School, Hannover, Germany

    Seema Dangwal, Katharina Schimmel, Ariana Foinquinos, Ke Xiao & Thomas Thum

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  1. Seema Dangwal
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  2. Katharina Schimmel
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  3. Ariana Foinquinos
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  4. Ke Xiao
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  5. Thomas Thum
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Correspondence to Thomas Thum .

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Editors and Affiliations

  1. Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover Klinik für Kardiologie und Angiologie, Hannover, Niedersachsen, Germany

    Johann Bauersachs

  2. Heart Institute, Stony Brook University , Stony Brook, New York, USA

    Javed Butler

  3. Heart and Lung Diseases, Bayer Pharma Aktiengesellschaft Heart and Lung Diseases, Wuppertal, Nordrhein-Westfalen, Germany

    Peter Sandner

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Dangwal, S., Schimmel, K., Foinquinos, A., Xiao, K., Thum, T. (2016). Noncoding RNAs in Heart Failure. In: Bauersachs, J., Butler, J., Sandner, P. (eds) Heart Failure. Handbook of Experimental Pharmacology, vol 243. Springer, Cham. https://doi.org/10.1007/164_2016_99

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