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Delta Opioid Receptor Pharmacology and Therapeutic Applications pp 227–260Cite as

Delta Opioid Receptors: Learning and Motivation

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 247))

Abstract

Delta opioid receptor (DOR) displays a unique, highly conserved, structure and an original pattern of distribution in the central nervous system, pointing to a distinct and specific functional role among opioid peptide receptors. Over the last 15 years, in vivo pharmacology and genetic models have allowed significant advances in the understanding of this role. In this review, we will focus on the involvement of DOR in modulating different types of hippocampal- and striatal-dependent learning processes as well as motor function, motivation, and reward. Remarkably, DOR seems to play a key role in balancing hippocampal and striatal functions, with major implications for the control of cognitive performance and motor function under healthy and pathological conditions.

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Change history

  • 16 July 2019

    The book was inadvertently published with error in the following chapters.

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  1. Physiologie de la Reproduction et des Comportements, INRA UMR-0085, CNRS UMR-7247, INSERM, Université François Rabelais, IFCE, 37380, Nouzilly, France

    L. P. Pellissier, J. A. J. Becker & J. Le Merrer

  2. Département de Neurosciences, Institut de Génomique fonctionnelle, INSERM U-661, CNRS UMR-5203, 34094, Montpellier, France

    C. N. Pujol

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  1. L. P. Pellissier
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    Emily M. Jutkiewicz

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Pellissier, L.P., Pujol, C.N., Becker, J.A.J., Le Merrer, J. (2016). Delta Opioid Receptors: Learning and Motivation. In: Jutkiewicz, E. (eds) Delta Opioid Receptor Pharmacology and Therapeutic Applications. Handbook of Experimental Pharmacology, vol 247. Springer, Cham. https://doi.org/10.1007/164_2016_89

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