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Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)

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Free Fatty Acid Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 236))

Abstract

The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders. Ongoing investigations of the pharmacological functions of FFA4 and validation of its potential as a therapeutic target depend critically on the appropriateness and quality of the available pharmacological probes or tool compounds. After a brief summary of the pharmacological functions of FFA4 and some general considerations on desirable properties for these pharmacological tool compounds, the individual compounds that have been or are currently being used as tools for probing the function of FFA4 in various in vitro and in vivo settings will be discussed and evaluated.

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Authors and Affiliations

  1. Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark

    Steffen V. F. Hansen & Trond Ulven

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  1. Steffen V. F. Hansen
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  2. Trond Ulven
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Correspondence to Trond Ulven .

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  1. Inst. Molecular, Cell & Systems Biology, University of Glasgow, Glasgow, Lanarkshire, United Kingdom

    Graeme Milligan

  2. Dep of Applied Biological Science, Tokyo Univ of Agriculture and Technology, Fuchu-shi, Tokyo, Japan

    Ikuo Kimura

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Hansen, S.V.F., Ulven, T. (2016). Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120). In: Milligan, G., Kimura, I. (eds) Free Fatty Acid Receptors. Handbook of Experimental Pharmacology, vol 236. Springer, Cham. https://doi.org/10.1007/164_2016_60

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