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Viruses That Exploit Actin-Based Motility for Their Replication and Spread

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The Actin Cytoskeleton

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 235))

Abstract

The actin cytoskeleton is a crucial part of the eukaryotic cell. Viruses depend on host cells for their replication, and, as a result, many have developed ways of manipulating the actin network to promote their spread. This chapter reviews the various ways in which viruses utilize the actin cytoskeleton at discrete steps in their life cycle, from entry into the host cell, replication, and assembly of new progeny to virus release. Various actin inhibitors that function in different ways to affect proper actin dynamics can be used to parse the role of actin at these steps.

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  1. The School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia

    N. Bishara Marzook & Timothy P. Newsome

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  1. N. Bishara Marzook
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  1. Cell Biology, Life Sciences, BRICS, TU Braunschweig, Braunschweig, Germany

    Brigitte M. Jockusch

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Marzook, N.B., Newsome, T.P. (2016). Viruses That Exploit Actin-Based Motility for Their Replication and Spread. In: Jockusch, B. (eds) The Actin Cytoskeleton. Handbook of Experimental Pharmacology, vol 235. Springer, Cham. https://doi.org/10.1007/164_2016_41

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