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Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

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Book cover Pharmacology of Mitochondria

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 240))

Abstract

Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.

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Acknowledgments

This work was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 22592093 to H.J.M.) and the Strategic Promotion Program for Basic Nuclear Research (to H.J.M.) of the Ministry of Education, Culture, Sports, Science and Technology of Japan, and the Program for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry (BRAIN) (to H.J.M.) by the Ministry of Agriculture, Forestry and Fisheries of Japan. M.J.D. gratefully acknowledges financial support from the Novo Nordisk Foundation (Laureate Research Grant NNF13OC0004294).

Conflict of Interest

No potential conflicts of interest were disclosed.

Author information

Authors and Affiliations

  1. Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan

    Hiroko P. Indo, Shigeaki Suenaga & Hideyuki J. Majima

  2. Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan

    Hiroko P. Indo & Hideyuki J. Majima

  3. Graduate Center of Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40506, USA

    Hiroko P. Indo & Daret K. St Clair

  4. The Heart Research Institute, 7 Eliza Street, Newtown, NSW, 2042, Australia

    Clare L. Hawkins

  5. Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia

    Clare L. Hawkins

  6. Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan

    Ikuo Nakanishi & Ken-ichiro Matsumoto

  7. Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki Prefecture, 305-8575, Japan

    Hirofumi Matsui

  8. Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, Copenhagen, 2200, Denmark

    Michael J. Davies

  9. Division of Oxidative Stress Research, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan

    Toshihiko Ozawa

Authors
  1. Hiroko P. Indo
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  2. Clare L. Hawkins
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  3. Ikuo Nakanishi
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  4. Ken-ichiro Matsumoto
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  5. Hirofumi Matsui
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  6. Shigeaki Suenaga
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  7. Michael J. Davies
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  8. Daret K. St Clair
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  9. Toshihiko Ozawa
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  10. Hideyuki J. Majima
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Corresponding authors

Correspondence to Hiroko P. Indo , Clare L. Hawkins or Hideyuki J. Majima .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Harpreet Singh

  2. Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Shey-Shing Sheu

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© 2016 Springer International Publishing Switzerland

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Indo, H.P. et al. (2016). Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. In: Singh, H., Sheu, SS. (eds) Pharmacology of Mitochondria. Handbook of Experimental Pharmacology, vol 240. Springer, Cham. https://doi.org/10.1007/164_2016_117

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