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Influence of Sensory Innervation on Epithelial Renewal and Wound Healing

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Vascular Surgery, Neurosurgery, Lower Extremity Ulcers, Antimicrobials, Wound Assessment, Care, Measurement and Repair

Part of the book series: Recent Clinical Techniques, Results, and Research in Wounds ((RCTRRW,volume 5))

Abstract

Neurons at sensory ganglia are widely known for their ability to transmit external or internal information toward the brain. A subpopulation of these neurons constitutively synthesizes the neuropeptide substance P (SP) and calcitonin gene-related peptide (CGRP). These peptides are related to pain transmission in the spinal cord, but in periphery, these peptides have a wide spectrum of biological effects. Noceffector is the term adopted to designate those peptidergic neurons at sensory ganglia which participate in maintaining tissue homeostasis. Here, we describe the role of noceffector on epithelial homeostasis both in noninjury conditions and during wound healing. Remarkably, peptidergic terminals seem to be an active participant of stem cell physiology.

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  1. Laboratory of Cell Communication and Extracellular Vesicles, Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    Juan Alfonso Martínez-Greene & E. Martínez-Martínez

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  1. Juan Alfonso Martínez-Greene
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    Melvin A. Shiffman

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    Mervin Low

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Martínez-Greene, J.A., Martínez-Martínez, E. (2018). Influence of Sensory Innervation on Epithelial Renewal and Wound Healing. In: Shiffman, M., Low, M. (eds) Vascular Surgery, Neurosurgery, Lower Extremity Ulcers, Antimicrobials, Wound Assessment, Care, Measurement and Repair. Recent Clinical Techniques, Results, and Research in Wounds, vol 5. Springer, Cham. https://doi.org/10.1007/15695_2018_130

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