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pp 1-27 | Cite as

Poly(lactic acid) as Biomaterial for Cardiovascular Devices and Tissue Engineering Applications

  • Waled Hadasha
  • Deon Bezuidenhout
Chapter
Part of the Advances in Polymer Science book series

Abstract

Synthetic bioabsorbable polymers, such as poly-lactic acid (PLA) and its copolymers (PLA-based polymers), have attracted a lot of attention in the medical field. With their excellent biocompatibility, mechanical properties, and tunable biodegradability, PLA-based polymers have found uses in various clinical applications, including sutures and orthopedic fixation devices (e.g. pins, plates, and screws). PLA-based polymers have also been the materials of choice for various cardiovascular applications. For example, they are extensively used as coatings for metallic drug-eluting coronary stents and in the development of the new generation of fully bioresorbable vascular scaffolds. In addition, the emergence of tissue engineering and regenerative medicine (TERM) has further extended the applications of PLA. In this chapter, we discuss the importance of PLA-based polymers as biomaterials and review the applications of this family of materials in cardiovascular applications, specifically in coronary stenting and TERM approaches to vascular grafts, heart valves, and cardiac patches. A brief insight is also given into the current market value and growth potential of PLA-based biomaterials.

Keywords

Biomaterial Cardiac patches Heart valves PLA Stents Tissue engineering Vascular grafts 

Notes

Acknowledgements

The authors wish to thank the National Research Foundation of South Africa Incentive Program for Rated Researchers (CPRR) and the University of Cape Town Faculty of Health Sciences Postdoctoral Fellowship for funding and support.

Potential Conflict of Interest None.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Cardiovascular Research Unit, Christiaan Barnard Division of Cardiothoracic Surgery, Faculty of Health SciencesUniversity of Cape TownCape TownSouth Africa

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