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Poly(lactic acid) Controlled Drug Delivery

  • Jiannan Li
  • Jianxun Ding
  • Tongjun Liu
  • Jessica F. Liu
  • Lesan Yan
  • Xuesi Chen
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 282)

Abstract

Various drug delivery systems are being rapidly developed for controlled drug release, improved efficacy, and reduced side effects with the goal of improving quality of life for patients and curing disease. Poly(lactic acid) (PLA) possesses numerous advantages compared with other polymers, including biocompatibility, biodegradability, low cost, environmental friendliness, and easily modified mechanical properties. These properties make PLA a promising polymer for biomedical applications. This review introduces the specific characteristics of PLA that enable its application for controlled drug delivery and describes different forms of PLA used for drug delivery, including nanoparticles, microspheres, hydrogels, electrospun fibers, and scaffolds. Previous work is summarized and future development is discussed.

Keywords

Controlled drug release Electrospun fiber Hydrogel Microparticle Nanoparticle Poly(lactic acid) Scaffold 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Jiannan Li
    • 1
    • 2
  • Jianxun Ding
    • 1
  • Tongjun Liu
    • 2
  • Jessica F. Liu
    • 3
  • Lesan Yan
    • 3
  • Xuesi Chen
    • 1
  1. 1.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied ChemistryChinese Academy of ScienceChangchunPeople’s Republic of China
  2. 2.Department of General SurgeryThe Second Hospital of Jilin UniversityChangchunPeople’s Republic of China
  3. 3.Department of BioengineeringUniversity of PennsylvaniaPhiladelphiaUSA

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