Computational Studies of Biomembrane Systems: Theoretical Considerations, Simulation Models, and Applications

  • Markus DesernoEmail author
  • Kurt Kremer
  • Harald Paulsen
  • Christine Peter
  • Friederike Schmid
Part of the Advances in Polymer Science book series (POLYMER, volume 260)


This chapter summarizes several approaches combining theory, simulation, and experiment that aim for a better understanding of phenomena in lipid bilayers and membrane protein systems, covering topics such as lipid rafts, membrane-mediated interactions, attraction between transmembrane proteins, and aggregation in biomembranes leading to large superstructures such as the light-harvesting complex of green plants. After a general overview of theoretical considerations and continuum theory of lipid membranes we introduce different options for simulations of biomembrane systems, addressing questions such as: What can be learned from generic models? When is it expedient to go beyond them? And, what are the merits and challenges for systematic coarse graining and quasi-atomistic coarse-grained models that ensure a certain chemical specificity?


Coarse graining Curvature elasticity Lipid bilayer Mediated interactions Multiscaling Simulation 



We would like to thank the many coworkers and colleagues who have contributed to the research reported here, in particular Ira Cooke, Jemal Guven, Vagelis Harmandaris, Gregoria Illya, Martin Müller, Benedict Reynwar, Ira Rothstein, Cem Yolcu, Frank Brown, Olaf Lenz, Sebastian Meinhardt, Peter Nielaba, Beate West, Ananya Debnath, Christoph Globisch, Christoph Junghans, Shahoua Ding, Sabine Wiegand, Sandra Ritz, and Eva Sinner.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Markus Deserno
    • 1
    Email author
  • Kurt Kremer
    • 2
  • Harald Paulsen
    • 3
  • Christine Peter
    • 4
  • Friederike Schmid
    • 5
  1. 1.Department of PhysicsCarnegie Mellon UniversityPittsburghUSA
  2. 2.Max-Planck-Institute for Polymer ResearchMainzGermany
  3. 3.Department of BiologyUniversity of MainzMainzGermany
  4. 4.Department of ChemistyUniversity of KonstanzConstanceGermany
  5. 5.Institute of PhysicsUniversity of MainzMainzGermany

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