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Bio-synthetic Polymer Conjugates pp 37–70Cite as

Chemical Strategies for the Synthesis of Protein–Polymer Conjugates

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 253))

Abstract

Protein-polymer conjugates have achieved tremendous attention in the last few years. The synergistic combination of properties has led to certain advantages in bio-applications. Over the past few years, numerous chemical strategies have been developed to conjugate different synthetic polymers onto proteins, most of which can be summarized within the scope of click-chemistry. Here we highlight conjugation strategies based on available functional groups present on the synthetic polymer and existing groups of proteins from the natural pool. In particular, the chapter organizes the various possible reactions by classes of functional groups present on protein surfaces, deriving from selected amino acid residues.

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Acknowledgment

B. Jung gratefully acknowledges a fellowship funded through the Excellence Initiative (DFG/GSC 266).

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Authors and Affiliations

  1. Graduate School Materials Science in Mainz, Institute of Organic Chemistry, University of Mainz, Duesbergweg 10-14, 55099, Mainz, Germany

    Björn Jung

  2. Institute for Technical and Macromolecular Chemistry, University of Hamburg, Bundesstrasse 45, 20146, Hamburg, Germany

    Patrick Theato

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  1. Björn Jung
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  1. Research Campus Golm, Department of Colloid Chemistry, Max Planck Institute of Colloids and Int, Research Campus Golm, Potsdam, 14424, Germany

    Helmut Schlaad

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Jung, B., Theato, P. (2012). Chemical Strategies for the Synthesis of Protein–Polymer Conjugates. In: Schlaad, H. (eds) Bio-synthetic Polymer Conjugates. Advances in Polymer Science, vol 253. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2012_169

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