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Biodegradable Polymeric Assemblies for Biomedical Materials

  • Yuichi OhyaEmail author
  • Akihiro Takahashi
  • Koji Nagahama
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 247)

Abstract

Recently, self-assembled systems using biodegradable polymers at the nanometer scale, such as microspheres, nanospheres, polymer micelles, nanogels, and polymersomes, have attracted much attention especially in biomedical fields. To construct such self-assembled systems, it is extremely important to have precise control of intermolecular noncovalent interactions, such as hydrophobic interactions based on their amphiphilic molecular structures. Biodegradable polymers, especially aliphatic polyesters such as polylactide, polyglycolide, poly(ε-caplolactone) and their copolymers, have been used as biomedical materials for a long time. This chapter is mainly focused on aliphatic polyesters and related polymers, and reviews the synthetic methods for amphiphilic biodegradable polymers containing aliphatic polyesters as components. Moreover, the application of various types of self-assembly systems using amphiphilic biodegradable copolymers such as micro- or nanosized particles (microspheres, nanospheres, polymer micelles, nanogels, polymersomes), supramolecular physically interlocked systems, and stimuli-responsive systems for biomedical use such as drug delivery systems are also reviewed.

Keywords

Aliphatic polyesters Amphiphilic polymers Polymer micelles Self-assembly Smart materials 

Abbreviations

5FU

5-Fluorouracil

Ala

Alanine

Arg

Arginine

Asp

Aspartic acid

ATRP

Atom transfer radical polymerization

BSA

Bovine serum albumin

CD

Cyclodextrin

cDP

Cyclodepsipeptide

CHESG

Cholesterol group-modified enzymatically synthesized glycogen

CHP

Cholesterol–pullulan

CL

ε-Caprolactone

CMC

Critical micelle concentration

Cys

Cysteine

DDS

Drug delivery system

Dex

Dextran

DLA

d-Lactide

DMAE

Dimethylaminoethyl

DTT

Dithiothreitol

DXO

1,4-Dioxepan-5-one

DXR

Doxorubicin

EP

Ethyl ethylene phosphate

EPR

Enhanced permeability and retention

FDA

Food and Drug Administration

FITC

Fluorescein isothiocyanate

GA

Glycolide

Glc

Glycolic acid

Gly

Glycine

HA

Hyaluronic acid

HMDI

Hexamethylene diisocyanate

HPEI

Heparin–polyethyleneimine

IP

Injectable polymer

IPP

Isopropyl ethylene phosphate

LA

Lactide

LCST

Lower critical solution temperature

Leu

Leucine

LH-RH

Luteinizing hormone-releasing hormone

LLA

l-Lactide

LSEC

Liver sinusoidal endothelial cell

Lys

Lysine

MA

Malic acid

MDBE

Malide dibenzyl ester

MeO

Methoxy

ML

Mevalonolactone

mRNA

Messenger RNA

MS

Microsphere

NCA

N-carboxy anhydride

NIRF

Near-infrared fluorescence

NMR

Nuclear magnetic resonance

NS

Nanosphere

o/w

Oil in water

OCL

Oligocaprolactone

Oct

Octylate

P2VP

Poly(2-vinylpyridine)

PAA

Poly(acrylic acid)

PBD

Poly(butadiene)

PBS

Phosphate-buffered saline

PCL

Poly(ε-caplolactone)

PDLA

Poly(d-lactide)

PDP

Polydepsipeptide

PEE

Poly(ethyl ethylene)

PEG

Poly(ethylene glycol)

PEGMA

Poly(ethylene glycol) methacrylate

PEO

Poly(ethyle oxide)

PGA

Poly(glycolic acid), polyglycolide

PIC

Polyion complex

PLA

Poly(lactic acid), polylactide

PLGA

Poly(lactide-co-glycolide)

PLLA

Poly(l-lactide)

PMA

Poly(malic acid)

PMPC

Poly(2-methacryloyloxyethyl phosphorylcholine)

PNIPAAm

Poly(N-isopropylacrylamide)

pPRX

Pseudopolyrotaxane

PRX

Polyrotaxane

PS

Polystyrene

PTMC

Poly(trimethylene carbonate)

PTX

Paclitaxel

PVA

Poly(vinyl alcohol)

RES

Reticuloendothelial system

RGD

Arginine–glycine–aspartic acid

ROP

Ring-opening polymerization

SC

Stereocomplex

Ser

Serine

siRNA

Small interfering RNA

SMP

Shape-memory polymers

TCA

Tricarboxylic acid

Tg

Glass transition temperature

THF

Tetrahydrofuran

Thr

Threonine

Tm

Melting temperature

TMC

Trimethylene carbonate

TMS

Trimethylsilyl

Tyr

Tyrosine

w/o/w

Water in oil in water

References

  1. 1.
    Auras R, Lim LK, Selke EM, Tsuji H (2010) Poly(lactic acid): synthesis, structures, properties, and applications. Wiley, Hoboken, NJGoogle Scholar
  2. 2.
    Jeong B, Kim SW, Bae YH (2002) Adv Drug Deliv Rev 54:37Google Scholar
  3. 3.
    Kissel T, Li Y, Unger F (2002) Adv Drug Deliv Rev 54:99Google Scholar
  4. 4.
    Luten J, van Nostrum CF, De Smedt SC, Hennink WE (2008) J Control Release 126:97Google Scholar
  5. 5.
    Ulery BD, Nair LS, Laurencin CT (2001) J Polym Sci B Polym Phys 49:832Google Scholar
  6. 6.
    Nair LS, Laurencin CT (2006) Adv Biochem Eng Biotechnol 102:47Google Scholar
  7. 7.
    Nair LS, Laurencin CT (2007) Prog Polym Sci 32:762Google Scholar
  8. 8.
    Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM (1999) Chem Rev 99:3181Google Scholar
  9. 9.
    Drumright RE, Gruber PR, Henton DE (2000) Adv Mater 12:1841Google Scholar
  10. 10.
    Dechy-Cabaret O, Martin-Vaca B, Bourissou D (2004) Chem Rev 104:6147Google Scholar
  11. 11.
    Jacobson GB, Shinde R, Contag CH, Zare RN (2008) Angew Chem Int Ed 47:7880Google Scholar
  12. 12.
    Wei G, Ma PX (2008) Adv Funct Mater 18:3568Google Scholar
  13. 13.
    Albertsson AC, Varma IK, Lochab B, Finne-Wistrand A, Kumar K (2010) In: Auras R, Lim LK, Selke EM, Tsuji H (eds) Poly(lactic acid): synthesis, structures, properties, and applications. Wiley, Hoboken, NJ, p 43Google Scholar
  14. 14.
    Ouchi T, Ohya Y (2004) J Polym Sci A Polym Chem 42:453Google Scholar
  15. 15.
    Sun H, Meng F, Dias AA, Hendriks M, Feijen J, Zhong Z (2011) Biomacromolecules 12:1937Google Scholar
  16. 16.
    Oh JK (2011) Soft Matter 7:5096Google Scholar
  17. 17.
    Feng Y, Lu J, Behl M, Lendlein A (2010) Macromol Biosci 10:1008Google Scholar
  18. 18.
    Pounder RJ, Dove AP (2010) Polym Chem 1:260Google Scholar
  19. 19.
    Gaucher G, Marchessault RH, Leroux J-C (2010) J Control Release 143:2Google Scholar
  20. 20.
    Chvapil M (1977) J Biomed Mater Res 11:721Google Scholar
  21. 21.
    Tabata Y, Ikada Y (1988) Adv Drug Deliv Rev 31:287Google Scholar
  22. 22.
    Rousou JA, Engelman RM, Breyer RH (1984) Ann Thorac Surg 38:409Google Scholar
  23. 23.
    Gopferich A (1997) Macromolecules 30:2598Google Scholar
  24. 24.
    Coulembier O, Degee P, Hedrick JL, Dubois P (2006) Prog Polym Sci 31:723Google Scholar
  25. 25.
    Hill JW (1932) J Am Chem Soc 54:4105Google Scholar
  26. 26.
    Rosen HB, Chang J, Wnek GE, Linhardt RJ, Langer R (1983) Biomaterials 4:131Google Scholar
  27. 27.
    Domb AJ, Gallardo CF, Langer R (1989) Macromolecules 22:3200Google Scholar
  28. 28.
    Pospiech D, Jomber H, Jehnichen D, Haussler L, Eckstein K, Scheibner H, Janke A, Kricheldorf HR, Petermann O (2005) Biomacromolecules 6:439Google Scholar
  29. 29.
    Qi M, Li X, Yang Y, Zhou S (2008) Eur J Pharm Biopharm 70:445Google Scholar
  30. 30.
    Heller J (1985) J Cotrol Release 2:167Google Scholar
  31. 31.
    Wang C, Ge Q, Ting D, Nguyen D, Shen H-R, Chen J, Eisen HN, Heller J, Langer R, Putnam D (2004) Nat Mater 3:190Google Scholar
  32. 32.
    Nguyen DN, Raghavan SS, Tashima LM, Lin EC, Fredette SJ, Langer RS, Wang C (2008) Biomaterials 29:2783Google Scholar
  33. 33.
    Heffernan MJ, Murthy N (2005) Bioconjug Chem 16:1340Google Scholar
  34. 34.
    Lee S, Yang SC, Heffernan MJ, Taylor WR, Murthy N (2007) Bioconjug Chem 18:4Google Scholar
  35. 35.
    Allcock HR, Kugel RL (1965) J Am Chem Soc 87:4216Google Scholar
  36. 36.
    Laurencin CT, Koh HJ, Neenan TX, Allcock HR, Langer RJ (1987) Biomed Mater Res 21:1231Google Scholar
  37. 37.
    Lapienis G, Penczek S (1974) Macromolecules 7:166Google Scholar
  38. 38.
    Kaluzynski K, Libisowski J, Penczek S (1976) Macromolecules 9:365Google Scholar
  39. 39.
    Wang YC, Tang LY, Sun TM, Li C-H, Xiong M-H, Wang J (2008) Biomacromolecules 9:388Google Scholar
  40. 40.
    Iwasaki Y, Wachiralarpphaithoon C, Akiyoshi K (2007) Macromolecules 40:8136Google Scholar
  41. 41.
    Chen R, Curran SJ, Curran JM, Hunt JA (2006) Biomaterials 27:4453Google Scholar
  42. 42.
    Athanasiou KA, Agrawal CM, Barber FA, Burkhart SS (1998) Arthroscopy 14:726Google Scholar
  43. 43.
    Wang YC, Lin MC, Wang DM, Hsieh HJ (2003) Biomaterials 24:1047Google Scholar
  44. 44.
    Porter JR, Henson A, Popat KC (2009) Biomaterials 30:780Google Scholar
  45. 45.
    Mo XM, Xu CY, Kotaki M, Ramakrishna S (2004) Biomaterials 25:1883Google Scholar
  46. 46.
    Katz AR, Turner RJ (1970) Surg Gynecol Obstet 131:701Google Scholar
  47. 47.
    Echeverria EA, Jimenez J (1970) Surgery 131:1Google Scholar
  48. 48.
    Knight S, Erggelet C, Endres M, Sittinger M, Kaps C, Stussi E (2007) J Biomed Mater Res B Appl Biomater 83:50Google Scholar
  49. 49.
    Wang L, Dormer NH, Bonewald LF, Detamore MS (2010) Tissue Eng A 16:1937Google Scholar
  50. 50.
    Dunne N, Jack V, O’Hara R, Farrar D, Buchanan FJ (2010) Mater Sci Mater Med 21:2263Google Scholar
  51. 51.
    Pihlajamaki HK, Salminen ST, Tynninen O, Bostman OM, Laitinen O (2010) Calcif Tissue Int 87:90Google Scholar
  52. 52.
    Erggelet C, Neumann K, Endres M, Haberstroh K, Sittinger M, Kaps C (2007) Biomaterials 28:5570Google Scholar
  53. 53.
    Frisbie DD, Lu Y, Kawcak CE, DiCarlo EF, Binette F, McIlwraith CW (2009) Am J Sports Med 37:71SGoogle Scholar
  54. 54.
    Mahmoudifar N, Doran PM (2010) Biomaterials 31:3858Google Scholar
  55. 55.
    Pihlajamaki H, Tynninen O, Karjalainen P, Rokkanen PJ (2007) Biomed Mater Res A 81:987Google Scholar
  56. 56.
    Xu L, Cao D, Liu W, Zhou G, Zhang WJ, Cao Y (2010) Biomaterials 31:3894Google Scholar
  57. 57.
    Ohara T, Itaya T, Usami K, Ando Y, Sakurai H, Honda MJ, Ueda M, Kagami HJ (2010) Biomed Mater Res A 94:800Google Scholar
  58. 58.
    Darney PD, Monroe SE, Klaisle CM, Alvarado A (1989) Am J Obstet Gynecol 160:1292Google Scholar
  59. 59.
    Gunatillake P, Mayadunne R, Adhikari R (2006) Biotechnol Annu Rev 12:301Google Scholar
  60. 60.
    Pankajakshan D, Philipose LP, Palakkal M, Krishnan K, Krishnan LK (2008) J Biomed Mater Res B Appl Biomater 87:570Google Scholar
  61. 61.
    Plikk P, Malberg S, Albertsson A-C (2009) Biomacromolecules 10:1259Google Scholar
  62. 62.
    Zuo Y, Yang F, Wolke JGC, Li Y, Jansen JA (2010) Acta Biomater 6:1238Google Scholar
  63. 63.
    Li J, Li L, Yu H, Cao H, Gao C, Gong Y (2006) ASAIO J 52:321Google Scholar
  64. 64.
    Garkhal K, Verma S, Tikoo K, Kumar NJ (2007) Biomed Mater Res A 82:747Google Scholar
  65. 65.
    Guarino V, Ambrosio L (2008) Acta Biomater 4:1778Google Scholar
  66. 66.
    Gunatillake P, Mayadunne R, Adhikari R (2006) Biotechnol Annu Rev 12:301Google Scholar
  67. 67.
    Miller RA, Brady JM, Cutright DE (1977) J Biomed Mater Res 11:711Google Scholar
  68. 68.
    Middleton JC, Tipton A (1998) J Med Plast Biomater 31Google Scholar
  69. 69.
    Lu XL, Sun ZJ, Cai W, Gao ZY (2008) J Mater Sci Mater Med 19:395Google Scholar
  70. 70.
    Ito Y, Ochii Y, Fukushima K, Sugioka N, Takada K (2010) Int J Pharm 384:53Google Scholar
  71. 71.
    Lee WL, Foo WL, Widjaja E, Loo SC (2010) J Acta Biomater 6:1342Google Scholar
  72. 72.
    Rieger J, Freichels H, Imberty A, Putaux J-L, Delair T, Jerome C, Auzely-Velty R (2009) Biomacromolecules 10:651Google Scholar
  73. 73.
    Richter A, Olbrich C, Krause M, Kissel T (2010) Int J Pharm 389:244Google Scholar
  74. 74.
    Mathisen T, Masus K, Albertsson AC (1989) Macromolecules 22:3842Google Scholar
  75. 75.
    Ryner M, Albertsson AC (2002) Biomacromolecules 3:601Google Scholar
  76. 76.
    Finne A, Andronova A, Albertsson AC (2003) Biomcromolecules 4:1451Google Scholar
  77. 77.
    Miura Y, Aoyagi S, Kusada Y, Miyamoto K (1980) J Biomed Mater Res 14:619Google Scholar
  78. 78.
    Ouchi T, Fujino A (1989) Macromol Chem 190:1523Google Scholar
  79. 79.
    Ohya Y, Kobayashi H, Ouchi T (1991) React Polym 15:153Google Scholar
  80. 80.
    Ohya Y, Hirai K, Ouchi T (1992) Makromol Chem 193:1881Google Scholar
  81. 81.
    Braud C, Vert M (1985) Polym Bull 13:293Google Scholar
  82. 82.
    Fournie P, Domurado D, Guerin P, Braud C, Vert M, Madelmont JC (1990) J Bioact Compat Polym 5:381Google Scholar
  83. 83.
    Kimura Y, Shirotani K, Yamane H, Kitao T (1989) Kobunshi Ronbunshu 46:281Google Scholar
  84. 84.
    Kimura Y, Shirotani K, Yamane H, Kitao T (1993) Polymer 34:1741Google Scholar
  85. 85.
    Yamaoka T, Hotta Y, Kobayashi K, Kimura Y (1999) Int J Biol Macromol 25:265Google Scholar
  86. 86.
    Mahmud A, Xiong XB, Lavasanifar A (2006) Macromolecules 39:9419Google Scholar
  87. 87.
    Xiong XB, Mahmud A, Uludag H, Lavasanifar A (2008) Pharm Res 25:2555Google Scholar
  88. 88.
    Xiong XB, Ma Z, Lavasanifar A (2010) Biomaterials 31:757Google Scholar
  89. 89.
    Nottelet B, Tommaso CD, Mondon K, Gurny R, Moller M (2010) J Polym Sci A Polym Chem 48:3244Google Scholar
  90. 90.
    Pratt RC, Nederberg F, Waymouth RM, Hedrick JL (2008) Chem Commun 114Google Scholar
  91. 91.
    Fukushima K, Pratt RC, Nederberg F, Tan JPK, Yang YY, Waymouth RM, Hedrick JL (2008) Biomacromolecules 9:3051Google Scholar
  92. 92.
    Suriano F, Pratt R, Tan JPK, Wiradharma N, Nelson A, Yang YY, Dubois P, Hedrick JL (2010) Biomaterials 31:2637Google Scholar
  93. 93.
    Stewart FHC (1969) Aust J Chem 22:1291Google Scholar
  94. 94.
    Helder J, Kohn FE, Sato S, van den Berg JW, Feijen J (1985) Makromol Chem Rapid Commun 6:9Google Scholar
  95. 95.
    Helder J, Feijen J, Lee SJ, Kim SW (1986) Makromol Chem Rapid Commun 7:193Google Scholar
  96. 96.
    In’t Veld PJA, Dijkstra PJ, von Lochem JH, Feijen J (1990) Makromol Chem 191:1813Google Scholar
  97. 97.
    In’t Veld PJA, Wei-Ping Y, Klap R, Dijkstra PJ, Feijen J (1992) Makromol Chem 193:1927Google Scholar
  98. 98.
    EP 322154, Phizer Inc. invs: Fung FN, Glowaky RC (1989) Chemcal Abstr 113:103447Google Scholar
  99. 99.
    Samyn C, van Baylen M (1988) Makromol Chem Macromol Symp 19:255Google Scholar
  100. 100.
    Ouchi T, Shiratani M, Jinno M, Hirao M, Ohya Y (1993) Makromol Chem Rapid Commun 14:825Google Scholar
  101. 101.
    In’t Veld PJA, Dijkstra PJ, Feijen J (1993) Makromol Chem 193:2713Google Scholar
  102. 102.
    Ouchi T, Nozaki T, Okamoto Y, Shiratani M, Ohya Y (1996) Macromol Chem Phys 197:1823Google Scholar
  103. 103.
    Barrera DA, Zylstra E, Lansbury PT Jr, Langer R (1993) J Am Chem Soc 115:11010Google Scholar
  104. 104.
    Barrera DA, Zylstra E, Lansbury PT, Langer R (1995) Macromolecules 28:425Google Scholar
  105. 105.
    Cook AD, Hrkach JS, Gao NN, Johnson IM, Pajvani UB, Cannizzaro SM, Langer R (1997) J Biomed Mater Res 35:513Google Scholar
  106. 106.
    Ouchi T, Seike H, Nozaki T, Ohya Y (1998) J Polym Sci A Polym Chem 36:1283Google Scholar
  107. 107.
    Tasaka F, Miyazaki H, Ohya Y, Ouchi T (1999) Macromolecules 32:6386Google Scholar
  108. 108.
    Ohya Y, Matsunami H, Yamabe E, Ouchi T (2003) J Biomed Mater Res 65A:79Google Scholar
  109. 109.
    Ohya Y, Matsunami H, Ouchi T (2004) J Biomat Sci Polym Edn 15:111Google Scholar
  110. 110.
    Nagahama K, Ueda Y, Ouchi T, Ohya Y (2007) Biomacromolecules 8:3938Google Scholar
  111. 111.
    Nagahama K, Imai Y, Nakayama T, Ohmura J, Ouchi T, Ohya Y (2009) Polymer 50:3547Google Scholar
  112. 112.
    Gref R, Miralles G, Dellacherie E (1999) Polym Int 48:251Google Scholar
  113. 113.
    Zhu KJ, Xiangzhou L, Shilin YJ (1990) Appl Polym Sci 39:1Google Scholar
  114. 114.
    Penning JP, Dijkstra H, Pennings AJ (1993) Polymer 34:942Google Scholar
  115. 115.
    Zhu KJ, Bihai S, Shilin Y (1989) J Polym Sci A Polym Chem 27:2151Google Scholar
  116. 116.
    Piskin E, Kaitian X, Denkbas EB, Kucukyavuz ZJ (1995) Biomater Sci Polym Ed 7:359Google Scholar
  117. 117.
    Zhang X, Jackson JK, Burt HM (1996) Int J Pharm 132:195Google Scholar
  118. 118.
    Kimura Y, Matsuzaki Y, Yamane H, Kitao Y (1989) Polymer 30:1342Google Scholar
  119. 119.
    Vittaz M, Bazile D, Spenlehauer G, Verrecchia T, Veillard M, Puisieux F, Labarre D (1996) Biomaterials 17:1575Google Scholar
  120. 120.
    Rashkov I, Manolova N, Li SM, Espartero JL, Vert M (1996) Macromolecules 29:50Google Scholar
  121. 121.
    Park TG, Cohen S, Langer R (1992) Macromolecules 25:116Google Scholar
  122. 122.
    Chen X, McCarthy SP, Gross RA (1997) Macromolecules 30:4295Google Scholar
  123. 123.
    Li SM, Rashkov I, Espartero JL, Manolova N, Vert M (1996) Macromolecules 29:57Google Scholar
  124. 124.
    Hu DSG, Liu HJ (1994) Macromol Chem Phys 195:1213Google Scholar
  125. 125.
    Du YJ, Lemstra PJ, Nijenhui AJ, Aert HAMV, Bastiaansen C (1995) Macromolecules 28:2194Google Scholar
  126. 126.
    Hagan SA, Davis SS, Illum L, Davies MC, Garnett MC, Taylor DC, Irving MP, Tadros TF (1995) Langmuir 11:1482Google Scholar
  127. 127.
    Jeong B, Bae YH, Lee DS, Kim SW (1997) Nature 388:860Google Scholar
  128. 128.
    Lee DS, Shim MS, Kim SW, Lee H, Park I, Chang T (2001) Macromol Rapid Commun 22:587Google Scholar
  129. 129.
    Kissel T, Li YX, Volland C, Goerich S, Koneberg R (1996) J Control Release 39:315Google Scholar
  130. 130.
    Li Y, Kissel T (1998) Polymer 39:4421Google Scholar
  131. 131.
    Hiemstra C, Zhong Z, Dijkstra PJ, Feijen J (2005) Macromol Symp 224:119Google Scholar
  132. 132.
    Cai C, Wang L, Dong CM et al (2006) J Polym Sci A Polym Chem 44:2034Google Scholar
  133. 133.
    Chen W, Luo W, Wang S, Bei J (2003) Polym Adv Tech 14:245Google Scholar
  134. 134.
    Ohya Y, Nakai T, Nagahama K, Ouchi S, Tanaka S, Kato K (2006) J Bioact Compat Polym 21:557Google Scholar
  135. 135.
    Yamaoka T, Takahashi Y, Ohta T, Miyamoto M, Murakami A, Kimura Y (1999) J Polym Sci A Polym Chem 37:1513Google Scholar
  136. 136.
    Yamaoka T, Takahashi Y, Fujisato T, Lee CW, Tsuji T, Ohta T, Murakami A, Kimura Y (2001) J Biomed Mater Res 54:470Google Scholar
  137. 137.
    Lee J, Bae YH, Sohn YS, Jeong B (2006) Biomacromolecules 7:1729Google Scholar
  138. 138.
    Ouchi T, Miyazaki H, Arimura H, Tasaka F, Hamada A, Ohya Y (2002) J Polym Sci A Polym Chem 40:1218Google Scholar
  139. 139.
    Ouchi T, Miyazaki H, Arimura H, Tasaka F, Hamada A, Ohya Y (2002) J Polym Sci A Polym Chem 40:1426Google Scholar
  140. 140.
    Ouchi T, Seike H, Miyazaki H, Tasaka F, Ohya Y (2000) Design Monom Polym 3:279Google Scholar
  141. 141.
    Ouchi T, Uchida T, Arimura H, Ohya Y (2003) Biomacromolecules 4:477Google Scholar
  142. 142.
    Arimura H, Ohya Y, Ouchi T (2004) Macromol Rapid Commun 25:743Google Scholar
  143. 143.
    Arimura H, Ohya Y, Ouchi T (2005) Biomacromolecules 6:720Google Scholar
  144. 144.
    Schatz C, Lecommandoux S (2010) Macromol Rapid Commun 31:1664Google Scholar
  145. 145.
    Li BG, Zhang LM (2008) Carbohydr Polym 74:390Google Scholar
  146. 146.
    Liu JY, Zhang LM (2007) Carbohydr Polym 69:196Google Scholar
  147. 147.
    Sun H, Guo B, Li X, Cheng R, Meng F, Liu H, Zhong Z (2010) Biomacromolecules 11:848Google Scholar
  148. 148.
    Wang CH, Wang CH, Hsiue GH (2005) J Control Release 108:140Google Scholar
  149. 149.
    Kohori F, Sakai K, Aoyagi T, Yokoyama M, Sakurai Y, Okano T (1998) J Control Release 55:87Google Scholar
  150. 150.
    Nakayama M, Okano T, Miyazaki T, Kohori F, Sakai K, Yokoyama M (2006) J Control Release 115:46Google Scholar
  151. 151.
    You Y, Hong C, Wang W, Lu W, Pan C (2004) Macromolecules 37:9761Google Scholar
  152. 152.
    Hales M, Barner CK, Davis TP, Stenzel MM (2004) Langmuir 20:10809Google Scholar
  153. 153.
    Hsiue GH, Lo CL, Cheng CH, Lin CP, Huang CK, Chen HH (2007) J Polym Sci A Polym Chem 45:688Google Scholar
  154. 154.
    Huang CK, Lo CL, Chen HH, Hsiue GH (2007) Adv Funct Mater 17:2291Google Scholar
  155. 155.
    Watanabe J, Eriguchi T, Ishihara K (2002) Biomacromolecules 3:1375Google Scholar
  156. 156.
    Ohya Y, Maruhashi S, Ouchi T (1998) Macromolecules 31:4662Google Scholar
  157. 157.
    Ohya Y, Maruhashi S, Ouchi T (1998) Macromol Chem Phys 199:2017Google Scholar
  158. 158.
    Ouchi T, Kontani T, Ohya Y (2003) Polymer 44:3927Google Scholar
  159. 159.
    Ouchi T, Kontani T, Ohya Y (2003) J Polym Sci A Polym Chem 41:2462Google Scholar
  160. 160.
    Ouchi T, Kontani T, Saito T, Ohya Y (2005) J Biomater Sci Polym Ed 16:1035Google Scholar
  161. 161.
    Ouchi T, Kontani T, Aoki R, Saito T, Ohya Y (2006) J Polym Sci A Polym Chem 44:6402Google Scholar
  162. 162.
    Ouchi T, Minari T, Ohya Y (2004) J Polym Sci A Polym Chem 42:5482Google Scholar
  163. 163.
    Nagahama K, Mori Y, Ohya Y, Ouchi T (2007) Biomacromolecules 8:2135Google Scholar
  164. 164.
    Nagahama K, Ouchi T, Ohya Y (2008) Macromol Biosci 8:1044Google Scholar
  165. 165.
    de Jong SJ, De Smedt SC, Wahls MWC, Demeester J, Kettenes-van den Bosch JJ, Hennink WE (2000) Macromolecules 33:3680Google Scholar
  166. 166.
    de Jong SJ, van Eerdenbrugh B, van Nostrum CF, Kettenes-van den Bosch JJ, Hennink WE (2001) J Control Release 71:261Google Scholar
  167. 167.
    Hennink WE, De Jong SJ, Bos GW, Veldhuis TFJ, van Nostrum CF (2004) Int J Pharm 277:99Google Scholar
  168. 168.
    Ouchi T, Ichimura S, Ohya Y (2006) Polymer 47:429Google Scholar
  169. 169.
    Tasaka F, Ohya Y, Ouchi T (2001) Macromolecules 34:5494Google Scholar
  170. 170.
    Stolt M, Viljanmaa A, Sodergard A, Tormala P (2004) J Appl Polym Sci 91:196Google Scholar
  171. 171.
    Nagahama K, Ohya Y, Ouchi T (2006) Macromol Biosci 6:412Google Scholar
  172. 172.
    Nagahama K, Ohya Y, Ouchi T (2006) Polym J 38:852Google Scholar
  173. 173.
    Nagahama K, Nishimura Y, Ohya Y, Ouchi T (2007) Polymer 48:2649Google Scholar
  174. 174.
    Nagahama K, Shimizu K, Ouchi T, Ohya Y (2009) React Funct Polym 69:891Google Scholar
  175. 175.
    Tasaka F, Ohya Y, Ouchi T (2001) Macromol Rapid Commun 22:820Google Scholar
  176. 176.
    Ogawa Y, Okada H, Heya T (1989) J Pharm Pharmacol 41:439Google Scholar
  177. 177.
    Ogawa Y, Okada H, Yamamoto M, Shimamoto T (1988) Chem Pharm Bull 36:2576Google Scholar
  178. 178.
    Okada H (1997) Adv Drug Deliv Rev 28:43Google Scholar
  179. 179.
    Okada H, Heya T, Ogawa Y, Shimamoto T (1988) J Pharm Exp Ther 244:744Google Scholar
  180. 180.
    Ouchi T, Hamada A, Ohya Y (1999) Macromol Chem Phys 200:436Google Scholar
  181. 181.
    Ouchi T, Toyohara M, Arimura H, Ohya Y (2002) Biomacromolecules 3:885Google Scholar
  182. 182.
    Ouchi T, Sasakawa M, Arimura H, Ohya Y (2004) Polymer 45:1583Google Scholar
  183. 183.
    Ouchi T, Saito T, Kontani T, Ohya Y (2004) Macromol Biosci 4:458Google Scholar
  184. 184.
    Zhoua S, Liaob X, Lia X, Denga X, Lib H (2003) J Control Release 86:195Google Scholar
  185. 185.
    Liang H-F, Chen CT, Chen SC, Kulkarni AR, Chiu YL, Chen MC, Sung HW (2006) Biomaterials 27:2051Google Scholar
  186. 186.
    Saeed AO, Magnusson JP, Moradi E, Soliman M, Wang W, Stolnik S, Thurecht KJ, Howdle SM, Alexander C (2011) Bioconjug Chem 22:156Google Scholar
  187. 187.
    Liu SQ, Yang YY, Liu XM, Tong YW (2003) Biomacromolecules 4:1784Google Scholar
  188. 188.
    Yokoyama M, Inoue S, Kataoka K, Yui N, Okano T, Sakurai Y (1987) Makromol Chem Rapid Commun 8:431Google Scholar
  189. 189.
    Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, Inoue S (1990) J Control Release 11:269Google Scholar
  190. 190.
    Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K (1991) Cancer Res 51:3229Google Scholar
  191. 191.
    Yokoyama M, Okano T, Sakurai Y, Fukushima S, Okamoto K, Kataoka K (1999) J Drug Target 7:171Google Scholar
  192. 192.
    Kataoka K, Harada A, Nagasaki Y (2001) Adv Drug Deliv Rev 47:113Google Scholar
  193. 193.
    Torchilin VP (2002) Adv Drug Deliv Rev 54:235Google Scholar
  194. 194.
    Blanazs A, Armes SP, Ryan AJ (2009) Macromol Rapid Commun 30:267Google Scholar
  195. 195.
    Shin HC, Alani AWG, Rao DA, Rockich NC, Kwon GS (2009) J Control Release 140:294Google Scholar
  196. 196.
    Mikihail AS, Allen C (2011) Biomacromolecules 11:1273Google Scholar
  197. 197.
    Ding H, Sumer BD, Kessinger CW, Dong Y, Huang G, Boothman DA (2011) Gao J 151:271Google Scholar
  198. 198.
    Kim SH, Tan JPK, Nederberg F, Fukushima K, Colson J, Yang C, Nelson A, Yang YY, Hedrick JL (2010) Biomaterials 31:8063Google Scholar
  199. 199.
    Wang F, Wang YC, Yan LF, Wang J (2009) Polymer 50:5048Google Scholar
  200. 200.
    Liu J, Pang Y, Huang W, Huang X, Meng L, Zhu X, Zhou Y, Yan D (2011) Biomacromolecules 12:1567Google Scholar
  201. 201.
    Ohya Y, Takeda S, Shibata Y, Ouchi T, Maruyama A (2010) Macromol Chem Phys 211:1750Google Scholar
  202. 202.
    Ohya Y, Takeda S, Shibata Y, Ouchi T, Kano A, Iwata T, Mochizuki S, Taniwaki Y, Maruyama A (2011) J Control Release155:104Google Scholar
  203. 203.
    Discher DE, Eisenberg A (2002) Science 297:967Google Scholar
  204. 204.
    Meier W (2000) Chem Soc Rev 29:295Google Scholar
  205. 205.
    Torchilin VP (2005) Nat Rev Drug Discov 4:145Google Scholar
  206. 206.
    Onaca O, Enea R, Hughes DW, Meier W (2009) Macromol Biosci 9:129Google Scholar
  207. 207.
    Christian DA, Cai S, Bowen DM, Kim Y, Pajerowski D, Discher DE (2009) Eur J Pharm Biopharm 71:463Google Scholar
  208. 208.
    De Cock LJ, De Koker S, De Geest BG, Grooten J, Vervaet C, Remon JP, Sukhorukov GB, Antipina MN (2010) Angew Chem Int Ed 49:6954Google Scholar
  209. 209.
    Chang TMS (2005) Nat Rev Drug Discov 4:221Google Scholar
  210. 210.
    Kishimura A, Koide A, Osada K, Yamasaki Y, Kataoka K (2007) Angew Chem Int Ed 46:6085Google Scholar
  211. 211.
    Price AD, Zelikin AN, Wang Y, Caruso F (2009) Angew Chem Int Ed 48:329Google Scholar
  212. 212.
    Johnston APR, Zelikin AN, Caruso F (2007) Adv Mater 19:3727Google Scholar
  213. 213.
    Bally M, Bailey K, Sugahara K, Grieshaber D, Vörös J, Stäler B (2010) Small 6:2481Google Scholar
  214. 214.
    Holowka E, Sun VZ, Kamei DT, Deming TJ (2007) Nat Mater 6:52Google Scholar
  215. 215.
    Bangham AD (1993) Chem Phys Lipids 64:275Google Scholar
  216. 216.
    Ringsdorf H, Schlarb B, Venzmer J (1988) Angew Chem Int Ed 27:113Google Scholar
  217. 217.
    Yoshina-Ishii C, Miller GP, Kraft ML, Kool ET, Boxer SG (2005) J Am Chem Soc 127:1356Google Scholar
  218. 218.
    Discher BM, Won YY, Ege DS, Lee JCM, Bates FS, Discher DE, Hammer DA (1999) Science 284:1143Google Scholar
  219. 219.
    Lee JC, Bermudez H, Discher BM, Sheehan MA, Won YY, Bates FS, Discher DE (2001) Biotechnol Bioeng 73:135Google Scholar
  220. 220.
    Lee Y, Chang JB, Kim HK, Park TG (2006) Macromol Res 14:359Google Scholar
  221. 221.
    Pata V, Dan N (2003) Biophys J 85:2111Google Scholar
  222. 222.
    Wu J, Eisenberg A (2006) J Am Chem Soc 128:2880Google Scholar
  223. 223.
    Borchert U, Lipprandt U, Bilang M, Kimpfler A, Rank A, Peschka-Suss R, Schubert R, Lindner P, Forster S (2006) Langmuir 22:5843Google Scholar
  224. 224.
    Checot F, Lecommandoux S, Gnanou Y, Klok HA (2002) Angew Chem Int Ed 41:1339Google Scholar
  225. 225.
    Qin SH, Geng Y, Discher DE, Yang S (2006) Adv Mater 18:2905Google Scholar
  226. 226.
    Meng FH, Hiemstra C, Engbers GHM, Feijen J (2003) Macromolecules 36:3004Google Scholar
  227. 227.
    Meng FH, Engbers GHM, Feijen J (2005) J Control Release 101:187Google Scholar
  228. 228.
    Ghoroghchian PP, Li GZ, Levine DH, Davis KP, Bates FS, Hammer DA, Therien MJ (2006) Macromolecules 39:1673Google Scholar
  229. 229.
    Ahmed F, Discher DE (2004) J Control Release 96:37Google Scholar
  230. 230.
    Ahmed F, Pakunlu RI, Srinivas G, Brannan A, Bates F, Klein ML, Minko T, Discher DE (2006) Mol Pharm 3:340Google Scholar
  231. 231.
    Rameez S, Alosta H, Palmer AF (2008) Bioconjug Chem 19:1025Google Scholar
  232. 232.
    Kim Y, Tewari M, Pajerowski JD, Cai SS, Sen S, Williams J, Sirsi S, Lutz G, Discher DE (2009) J Control Release 134:132Google Scholar
  233. 233.
    Nagahama K, Saito T, Ouchi T, Ohya Y (2011) J Biomed Sci Polym Ed 22:407Google Scholar
  234. 234.
    Nagahama K, Ohmura J, Sakaue H, Ouchi T, Ohya Y, Yui N (2010) Chem Lett 39:250Google Scholar
  235. 235.
    Ooya T, Eguchi M, Yui N (2003) J Am Chem Soc 125:13016Google Scholar
  236. 236.
    Yui N (2009) Macromol Symp 279:158Google Scholar
  237. 237.
    Bellomo EG, Wyrsta MD, Pakstis L, Pochan DJ, Deming T (2004) Nat Mater 3:244Google Scholar
  238. 238.
    Makino A, Yamahara R, Ozeki E, Kimura S (2007) Chem Lett 36:1220Google Scholar
  239. 239.
    Tanisaka H, Kizaka-Kondoh S, Makino A, Tanaka S, Hiraoka M, Kimura S (2008) Bioconjug Chem 19:109Google Scholar
  240. 240.
    Koide A, Kishimura A, Osada K, Jang WD, Yamasaki Y, Kataoka K (2006) J Am Chem Soc 128:5988Google Scholar
  241. 241.
    Anraku Y, Kishimura A, Oba M, Yamasaki Y, Kataoka K (2010) J Am Chem Soc 131:1631Google Scholar
  242. 242.
    Makino A, Kimura S (2011) React Funct Polym 71:272Google Scholar
  243. 243.
    Makino A, Kizaka-Kondoh S, Yamahara R, Hara I, Kanzaki T, Ozeki E, Hiraoka M, Kimura S (2009) Biomaterials 30:5156Google Scholar
  244. 244.
    Matsumura Y, Maeda H (1986) Cancer Res 46:6387Google Scholar
  245. 245.
    Maeda H, Matsumura Y (1989) Crit Rev Ther Drug Carrier Syst 6:193Google Scholar
  246. 246.
    Oha JK, Lee DI, Park JM (2009) Prog Polym Sci 34:1261Google Scholar
  247. 247.
    Sasaki Y, Akiyoshi K (2010) Chem Rec 10:366Google Scholar
  248. 248.
    van de Manakker F, Vermonden T, van Nostrum CF, Hennink WE (2009) Biomacromolecules 10:3157Google Scholar
  249. 249.
    Kabanov AV, Vinogradov SV (2009) Angew Chem Int Ed 48:5418Google Scholar
  250. 250.
    Akiyoshi K, Deguchi N, Moriguchi N, Yamaguchi S, Sunamoto J (1993) Macromolecules 26:3062Google Scholar
  251. 251.
    Akiyoshi K, Ueminami A, Kurumada S, Nomura Y (2000) Macromolecules 33:6752Google Scholar
  252. 252.
    Akiyama E, Morimoto N, Kujawa P, Ozawa Y, Winnik FM, Akiyoshi K (2007) Biomacromolecules 8:2366Google Scholar
  253. 253.
    Lee KY, Jo WH, Kwon IC, Kim Y, Jeong SY (1998) Macromolecules 31:378Google Scholar
  254. 254.
    Nichifor M, Lopes A, Carpov A, Melo E (1999) Macromolecules 32:7078Google Scholar
  255. 255.
    Yusa S, Kamachi M, Morishima Y (1998) Langmuir 14:6059Google Scholar
  256. 256.
    Morimoto N, Qiu XP, Winnik FM, Akiyoshi K (2008) Macromolecules 41:5985Google Scholar
  257. 257.
    Sawada S, Akiyoshi K (2010) Macromol Biosci 10:353Google Scholar
  258. 258.
    Takahashi H, Sawada S, Akiyoshi K (2011) ACS Nano 5:337Google Scholar
  259. 259.
    Gou ML, Men K, Zhang J, Li YH, Song J, Luo S, Shi HS, Wen YJ, Guo G, Huang MJ, Zhao X, Qian ZY, Wei YQ (2010) ACS Nano 4:5573Google Scholar
  260. 260.
    Li F, Bae B, Na K (2010) Bioconjug Chem 21:1312Google Scholar
  261. 261.
    Tsuji H, Ikada Y (1993) Macromolecules 26:6918Google Scholar
  262. 262.
    Nagahama K, Hashizume M, Yamamoto H, Ouchi T, Ohya Y (2009) Langmuir 25:9734Google Scholar
  263. 263.
    Harada A, Li J, Kamachi M (1992) Nature 356:325Google Scholar
  264. 264.
    Nepogodiev SA, Stoddart JF (1998) Chem Rev 98:1959Google Scholar
  265. 265.
    Wenz G, Han BH, Müller A (2006) Chem Rev 106:782Google Scholar
  266. 266.
    Harada A, Hashidzume A, Yamaguchi H, Takashima Y (2009) Chem Rev 109:5974Google Scholar
  267. 267.
    Loethen S, Kim JM, Thompson DH (2007) Polym Rev 47:383Google Scholar
  268. 268.
    Li J, Loh XJ (2008) Adv Drug Deliv Rev 60:1000Google Scholar
  269. 269.
    Ooya T, Yui N (1998) Macromol Chem Phys 199:2311Google Scholar
  270. 270.
    Ooya T, Arizono K, Yui N (2000) Polym Adv Technol 11:642Google Scholar
  271. 271.
    Ooya T, Eguchi M, Yui N (2001) Biomacromolecules 2:200Google Scholar
  272. 272.
    Watanabe J, Ooya T, Yui N (1998) Chem Lett 1031Google Scholar
  273. 273.
    Watanabe J, Ooya T, Yui N (1999) J Biomater Sci Polym Ed 10:1275Google Scholar
  274. 274.
    Tachaboonyakiat W, Furubayashi T, Katoh M, Ooya T, Yui N (2004) J Biomater Sci Polym Ed 15:1389Google Scholar
  275. 275.
    Loethen S, Ooya T, Choi HS, Yui N, Thompson DH (2006) Biomacromolecules 7:2501Google Scholar
  276. 276.
    Ooya T, Ito A, Yui N (2005) Macromol Biosci 5:379Google Scholar
  277. 277.
    Ooya T, Choi HS, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Ito R, Kogure K, Harashima H (2006) J Am Chem Soc 128:3852Google Scholar
  278. 278.
    Harada A, Nishiyama T, Kawaguchi Y, Okada M, Kamachi M (1997) Macromolecules 30:7115Google Scholar
  279. 279.
    Harada A, Kawaguchi Y, Nishiyama T, Kamachi M (1997) Macromol Rapid Commun 18:535Google Scholar
  280. 280.
    Huang L, Allen E, Tonelli AE (1998) Polymer 39:4857Google Scholar
  281. 281.
    Kawaguchi Y, Nishiyama T, Okada M, Kamachi M, Harada A (2000) Macromolecules 33:4472Google Scholar
  282. 282.
    Rusa CC, Tonelli AE (2000) Macromolecules 33:5321Google Scholar
  283. 283.
    Shuai X, Porbeni FE, Wei M, Bullions T, Tonelli AE (2002) Macromolecules 35:3126Google Scholar
  284. 284.
    Shuai X, Porbeni FE, Wei M, Bullions T, Tonelli AE (2002) Macromolecules 35:3778Google Scholar
  285. 285.
    Lu J, Shin ID, Nojima S, Tonelli AE (2000) Polymer 41:5871Google Scholar
  286. 286.
    Shuai X, Porbeni FE, Wei M, Shin ID, Tonelli AE (2001) Macromolecules 34:7355Google Scholar
  287. 287.
    Shuai X, Porbeni FE, Wei M, Bullions T, Tonelli AE (2002) Macromolecules 35:2401Google Scholar
  288. 288.
    Choi HS, Ooya T, Sasaki S, Yui N, Ohya Y, Nakai T, Ouchi T (2003) Macromolecules 36:9313Google Scholar
  289. 289.
    Shuai X, Merdan T, Unger F, Kissel T (2005) Bioconjug Chem 16:322Google Scholar
  290. 290.
    Liu KL, Goh SH, Li J (2008) Macromolecules 41:6027Google Scholar
  291. 291.
    Ohya Y, Takamido S, Nagahama K, Ouchi T, Ooya T, Katoono R, Yui N (2007) Macromolecules 40:6441Google Scholar
  292. 292.
    Ohya Y, Takamido S, Nagahama K, Ouchi T, Katoono R, Yui N (2009) Biomacromolecules 10:2261Google Scholar
  293. 293.
    Wu DQ, Wang T, Lu B, Xu XD, Cheng SX, Jiang XJ, Zhang XZ, Zhuo RX (2008) Langmuir 24:10306Google Scholar
  294. 294.
    Hoffman AS (2002) Adv Drug Deliv Rev 54:3Google Scholar
  295. 295.
    Jeong B, Kim SW, Bae YH (2002) Adv Drug Deliv Rev 54:37Google Scholar
  296. 296.
    Heskins M, Guillent JE, James E (1968) J Macromol Sci Chem A2:1441Google Scholar
  297. 297.
    Chen GH, Hoffman AS (1995) Nature 373:49Google Scholar
  298. 298.
    Yamato M, Akiyama Y, Kobayashi J, Yang J, Kikuchi A, Okano T (2007) Prog Polym Sci 32:1123Google Scholar
  299. 299.
    Yoshida R, Uchida K, Kaneko Y, Sakai K, Kikuchi A, Sakurai Y, Okano T (1995) Nature 374:240Google Scholar
  300. 300.
    Heras CDL, Pennadam S, Alexander C (2005) Chem Soc Rev 34:276Google Scholar
  301. 301.
    Tachibana Y, Kurisawa M, Uyama H, Kakuchi T, Kobayashi S (2003) Chem Commun 106Google Scholar
  302. 302.
    Shimokuri T, Kaneko T, Serizawa T, Akashi M (2004) Macromol Biosci 4:407Google Scholar
  303. 303.
    Shimokuri T, Kaneko T, Akashi M (2004) J Polym Sci A Polym Chem 42:4492Google Scholar
  304. 304.
    Ohya Y, Toyohara M, Sasakawa M, Arimura H, Ouchi T (2005) Macromol Biosci 5:273Google Scholar
  305. 305.
    Renier ML, Kohn DH (1997) J Biomed Mater Res 34:95Google Scholar
  306. 306.
    Nguyen MK, Lee DS (2010) Macromol Biosci 10:563Google Scholar
  307. 307.
    Joo MK, Park MH, Choi BG, Jeong B (2009) J Mater Chem 19:5891Google Scholar
  308. 308.
    Jeong B, Bae YH, Kim SW (2000) J Control Release 63:155Google Scholar
  309. 309.
    Kim YJ, Choi S, Koh JJ, Lee M, Ko KS, Kim SW (2001) Pharm Res 18:548Google Scholar
  310. 310.
    Kim HK, Shim WS, Kim SE, Lee K, Kang E, Kim J, Kim K, Kwon IC, Lee DS (2009) Tissue Eng 15:923Google Scholar
  311. 311.
    Duvvuri S, Janoria KG, Mitra AK (2005) J Control Release 108:282Google Scholar
  312. 312.
    Li Z, Ning W, Wang J, Choi A, Lee P, Tyagi P, Huang L (2003) Pharm Res 20:884Google Scholar
  313. 313.
    Fujiwara T, Mukose T, Yamaoka T, Yamane H, Sakurai S, Kimura Y (2001) Macromol Biosci 1:204Google Scholar
  314. 314.
    Mukose T, Fujiwara T, Nakano J, Taniguchi I, Miyamoto M, Kimura Y, Teraoka I, Lee CW (2004) Macromol Biosci 4:361Google Scholar
  315. 315.
    Choi BG, Park MH, Cho SH, Joo MK, Oh HJ, Kim EH, Park K, Han DK, Jeong B (2010) Biomaterials 31:9266Google Scholar
  316. 316.
    Ohya Y, Yamamoto H, Nagahama K, Ouchi T (2009) J Polym Sci A Polym Chem 47:3892Google Scholar
  317. 317.
    Park K, Song S (2005) J Biomater Sci Polym Ed 16:1421Google Scholar
  318. 318.
    Park K, Song S (2006) J Biosci Bioeng 101:238Google Scholar
  319. 319.
    Jeong B, Lee KM, Gutowska A, An YH (2002) Biomacromolecules 3:865Google Scholar
  320. 320.
    Nagahama K, Ouchi T, Ohya Y (2008) Adv Funct Mater 18:1220Google Scholar
  321. 321.
    Nagahama K, Fujiura K, Enami S, Ouchi T, Ohya Y (2008) J Polym Sci A Polym Chem 46:6317Google Scholar
  322. 322.
    Osada Y, Matsuda A (1995) Nature 376:219Google Scholar
  323. 323.
    Langer R, Tirrell DA (2004) Nature 428:487Google Scholar
  324. 324.
    Lendlein A, Langer R (2002) Science 296:1673Google Scholar
  325. 325.
    Lendlein A, Kelch S (2002) Angew Chem Int Ed 41:2035Google Scholar
  326. 326.
    Lendlein A, Schmidt AM, Langer R (2001) Proc Natl Acad Sci USA 98:842Google Scholar
  327. 327.
    Rickert D, Lendlein A, Kelch S, Moses MA, Franke RP (2005) Clin Hemorheol Microcirc 32:117Google Scholar
  328. 328.
    Kelch S, Steuer S, Schmidt AM, Lendlein A (2007) Biomacromolecules 8:1018Google Scholar
  329. 329.
    Neuss S, Blomenkamp I, Stainforth R, Boltersdorf D, Jansen M, Butz N, Perez-Bouza A, Knüchel R (2009) Biomaterials 30:1697Google Scholar
  330. 330.
    Nagahama K, Ueda Y, Ouchi T, Ohya Y (2009) Biomacromolecules 10:1789Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Yuichi Ohya
    • 1
    • 2
    Email author
  • Akihiro Takahashi
    • 2
  • Koji Nagahama
    • 3
  1. 1.Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and BioengineeringKansai UniversitySuitaJapan
  2. 2.Organization for Research and Development of Innovative Science and Technology (ORDIST)Kansai UniversitySuitaJapan
  3. 3.Department of Nanobiochemistry, Frontiers of Innovative Research in Science and Technology (FIRST)Konan UniversityChuo-kuJapan

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