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Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering

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Chitosan for Biomaterials II

Part of the book series: Advances in Polymer Science ((POLYMER,volume 244))

Abstract

Chitosan is a nontoxic, biodegradable, and biocompatible polysaccharide of β(1-4)-linked d-glucosamine and N-acetyl-d-glucosamine. This derivative of natural chitin presents remarkable properties that have paved the way for the introduction of chitosan in the biomedical and pharmaceutical fields. Nevertheless, the properties of chitosan, such as its poor solubility in water or in organic solvents, can limit its utilization for a specific application. An elegant way to improve or to impart new properties to chitosan is the chemical modification of the chain, generally by grafting of functional groups, without modification of the initial skeleton in order to conserve the original properties. The functionalization is carried out on the primary amine group, generally by quaternization, or on the hydroxyl group. This review aims to provide an overview of chitosan and chitosan derivatives used for drug delivery, with a special emphasis on chemical modifications of chitosan to achieve specific biomedical purpose. The synthesis of the main chitosan derivatives will be reviewed. The applications of chitosan and these chitosan derivatives will be illustrated.

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Authors and Affiliations

  1. Centre for Education and Research on Macromolecules, University of Liège, Sart-Tilman, Building B6a, 4000, Liège, Belgium

    Raphaël Riva & Christine Jérôme

  2. Louvain Drug Research Institute, Université catholique de Louvain, Avenue Mounier, 73 B1 7312, 1200, Brussels, Belgium

    Héloïse Ragelle, Anne des Rieux, Nicolas Duhem & Véronique Préat

Authors
  1. Raphaël Riva
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  2. Héloïse Ragelle
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  3. Anne des Rieux
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  4. Nicolas Duhem
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  5. Christine Jérôme
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  6. Véronique Préat
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Corresponding author

Correspondence to Véronique Préat .

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Editors and Affiliations

  1. Nanosciences and Molecular Medicine, Amrita Institute of, Amrita Center for, Cochin, 682041, India

    Rangasamy Jayakumar

  2. , Department of Chemistry, SRM University, Kattankulathur, 603 203, India

    M. Prabaharan

  3. Faculty of Medicine, Institute of Biochemistry, University of Ancona, Ancona, 60100, Italy

    Riccardo A. A. Muzzarelli

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Riva, R., Ragelle, H., des Rieux, A., Duhem, N., Jérôme, C., Préat, V. (2011). Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering. In: Jayakumar, R., Prabaharan, M., Muzzarelli, R. (eds) Chitosan for Biomaterials II. Advances in Polymer Science, vol 244. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2011_137

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