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Use of Chitosan as a Bioactive Implant Coating for Bone-Implant Applications

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Chitosan for Biomaterials II

Part of the book series: Advances in Polymer Science ((POLYMER,volume 244))

Abstract

Chitosan is the deacetylated derivative of the natural polysaccharide, chitin. Chitosan has been shown to be biocompatible, biodegradable, osteoconductive, and to accelerate wound healing. These characteristics are largely due to its structural and chemical homology to hyaluronic acid and other proteoglycans found in extracellular matrices. Because of these properties, chitosan has been investigated as a coating for implant materials to promote osseointegration, and as a potential vehicle to deliver therapeutic agents to the local implant–tissue interface. The coating of chitosan onto implant alloy surfaces has been achieved via chemical reactions and electrodeposition mechanisms as well as by other methods such as dip coating and layer-by-layer assembly. This work examines the different mechanisms and bond strengths of chitosan coatings for implant alloys, coating composition and physiochemical properties, degradation, delivery of therapeutic agents, such as growth factors and antibiotics, and in vitro and in vivo compatibilities.

The authors Megan R. Leedy and Holly J. Martin contributed equally as first authors.

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Acknowledgement

Authors would like to acknowledge the Biomaterials Applications of Memphis (BAM) Research Laboratories at the University of Memphis-University of Tennessee Health Science Center for assistance in preparing work.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Memphis, Memphis, TN, 38152, USA

    Megan R. Leedy, P. Andrew Norowski, J. Amber Jennings, Warren O. Haggard & Joel D. Bumgardner

  2. Center for Advanced Vehicular Systems, Mississippi State University, Starkville, MS, 39762, USA

    Holly J. Martin

Authors
  1. Megan R. Leedy
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  2. Holly J. Martin
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  3. P. Andrew Norowski
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  4. J. Amber Jennings
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  5. Warren O. Haggard
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  6. Joel D. Bumgardner
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Corresponding author

Correspondence to Joel D. Bumgardner .

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Editors and Affiliations

  1. Nanosciences and Molecular Medicine, Amrita Institute of, Amrita Center for, Cochin, 682041, India

    Rangasamy Jayakumar

  2. , Department of Chemistry, SRM University, Kattankulathur, 603 203, India

    M. Prabaharan

  3. Faculty of Medicine, Institute of Biochemistry, University of Ancona, Ancona, 60100, Italy

    Riccardo A. A. Muzzarelli

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Leedy, M.R., Martin, H.J., Norowski, P.A., Jennings, J.A., Haggard, W.O., Bumgardner, J.D. (2011). Use of Chitosan as a Bioactive Implant Coating for Bone-Implant Applications. In: Jayakumar, R., Prabaharan, M., Muzzarelli, R. (eds) Chitosan for Biomaterials II. Advances in Polymer Science, vol 244. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2011_115

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