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Antibacterial Peptidomimetics: Polymeric Synthetic Mimics of Antimicrobial Peptides

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Polymer Composites – Polyolefin Fractionation – Polymeric Peptidomimetics – Collagens

Part of the book series: Advances in Polymer Science ((POLYMER,volume 251))

Abstract

Polymer-based peptidomimetics, or proteinomimetics, are a relatively young and dynamic field of research. The ability to successfully mimic the biochemical activity of antimicrobial peptides (AMPs) has been demonstrated by several groups. This has been accomplished by careful tuning of the molecule’s hydrophobicity and charge density. At the same time, many important questions remain to be answered, including the role of backbone rigidity, details of membrane insertion, and the role of curvature in the self-assemblies between these novel peptidemimetics and phospholipids. As the biological properties of polymeric synthetic mimics of AMPs (SMAMPs) result from the interplay of many parameters, it is not yet possible to predict the exact properties of such molecules from their mere chemical structure. However, as demonstrated here, the effect of certain design features such as charge and hydrophobicity on the properties across a polymer series is understood. Compared to the mechanistic specifics that are known about the interactions of AMPs or small antibacterial molecules with membranes and cells, relatively little is known concerning the interaction of polymeric SMAMPs with membranes. Beyond SMAMPs, numerous opportunities exist and protein transduction domain mimics are an active area of research in the Tew laboratory. These two examples, one quite new and the other studied for almost a decade, demonstrate that it is possible to teach synthetic polymers to behave like peptides, despite their lack of sequence specificity and secondary structure.

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Acknowledgment

This work was funded by ARO, MRSEC, NIH, and ONR. Funding by the German Research Foundation (DFG-Forschungsstipendium to K.L.) and the Ludcke Foundation (Fellowship to K.L.) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Polymer Science & Engineering, University of Massachusetts, Amherst, MA, 01003, USA

    Karen Lienkamp, Ahmad E. Madkour & Gregory N. Tew

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  1. Karen Lienkamp
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  2. Ahmad E. Madkour
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  3. Gregory N. Tew
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Corresponding author

Correspondence to Gregory N. Tew .

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Editors and Affiliations

  1. Hiyoshi-Honcho 6-27-12, Yokohama, 223-0062, Japan

    Akihiro Abe

  2. Ch. des Colombaires 10 A, Cully, 1096, Switzerland

    Hans-Henning Kausch

  3. DWI, Textile and Macromol. Chemistry, RWTH Aachen, Pauwelsstr. 8, Aachen, 52056, Germany

    Martin Möller

  4. Dept.of Chemistry, Univ. of Stellenbosch, Private Bag X1, Matieland, 7602, South Africa

    Harald Pasch

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Lienkamp, K., Madkour, A.E., Tew, G.N. (2010). Antibacterial Peptidomimetics: Polymeric Synthetic Mimics of Antimicrobial Peptides. In: Abe, A., Kausch, HH., Möller, M., Pasch, H. (eds) Polymer Composites – Polyolefin Fractionation – Polymeric Peptidomimetics – Collagens. Advances in Polymer Science, vol 251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2010_85

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