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Controlled Drug Release from Biodegradable Shape-Memory Polymers

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Shape-Memory Polymers

Part of the book series: Advances in Polymer Science ((POLYMER,volume 226))

Abstract

Biodegradable shape-memory polymers (SMPs) have attracted significant interest for biomedical applications. Modern concepts for biofunctional implants often comprise the controlled release of bioactive compounds to gain specific biofunctionalities. Therefore, a general strategy has been suggested for polymer systems combining degradability and shape-memory capability with controlled release of drugs. This chapter provides a detailed description of the molecular basis for such multifunctional SMPs including the selection of building blocks, the polymer morphology, and the three dimensional architecture. Moreover, drug loading and release, drug effects on thermomechanical properties of SMPs, and drug release patterns in a physiological environment are described and potential applications in minimally-invasive surgery are discussed.

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Acknowledgements

The authors thank Dr. Karolin Schmälzlin for support with some of the graphics.

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Authors and Affiliations

  1. Center for Biomaterial Development and Berlin-Brandenburg Center for Regenerative Therapies, Institute for Polymer Research, GKSS Research Center Geesthacht GmbH, Kantstrasse 55, 14513, Teltow, Germany

    Christian Wischke, Axel T. Neffe & Andreas Lendlein

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  1. Christian Wischke
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  2. Axel T. Neffe
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  3. Andreas Lendlein
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Correspondence to Andreas Lendlein .

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Editors and Affiliations

  1. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Wischke, C., Neffe, A.T., Lendlein, A. (2009). Controlled Drug Release from Biodegradable Shape-Memory Polymers. In: Lendlein, A. (eds) Shape-Memory Polymers. Advances in Polymer Science, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2009_29

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