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Shape-Memory Polymers for Biomedical Applications

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Shape-Memory Polymers

Part of the book series: Advances in Polymer Science ((POLYMER,volume 226))

Abstract

Shape-memory polymers (SMPs) are a class of mechanically functional “smart” materials that have generated substantial interest for biomedical applications. SMPs offer the ability to promote minimally invasive surgery, provide structural support, exert stabilizing forces, elute therapeutic agents, and biodegrade. This review focuses on several areas of biomedicine including vascular, orthopedic, and neuronal applications with respect to the progress and potential for SMPs to improve the standard of treatment in these areas. Fundamental studies on proposed biomedical SMP systems are discussed with regards to biodegradability, tailorability, sterilization, and biocompatibility. Lastly, a proposed research and development pathway for SMP-based biomedical devices is proposed based on trends in the recent literature.

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Abbreviations

ACL:

Anterior cruciate ligament

CHEM:

Cold hibernated elastic memory

DES:

Drug-eluting stent

\({E}_{\mathrm{r}}^{{\prime}}\) :

Rubbery modulus

EtO:

Ethylene oxide

FDA:

Food and Drug Administration

LTP:

Low temperature plasma

PCL:

Poly(ε-caprolactone)

PLA:

Polylactic acid

PLLA:

Poly(L-lactide)

SMP:

Shape-memory polymer

Tdeform :

Temperature of deformation

Tg :

Glass transition temperature

Tonset :

Onset of the glass transition

Ttrans :

Transition temperature

US:

United States

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Acknowledgments

The authors would like to thank Jack “Mac” Griffis MS for his expert consultation in vascular devices. The authors would also like to thank Kurt Jacobus Ph.D., Carl Frick Ph.D., Alicia M. Ortega, Sean Dixon, Jordan Rakes, and Jhordan Gil for their support and careful review of this work.

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Authors and Affiliations

  1. Research and Development, MedShape Solutions, Atlanta, GA, 30318, USA

    Christopher M. Yakacki & Ken Gall

  2. School of Materials Science and Engineering, The Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Christopher M. Yakacki & Ken Gall

  3. George Woodruff School of Mechanical Engineering, The Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Ken Gall

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  1. Christopher M. Yakacki
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Correspondence to Christopher M. Yakacki .

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Editors and Affiliations

  1. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Yakacki, C.M., Gall, K. (2009). Shape-Memory Polymers for Biomedical Applications. In: Lendlein, A. (eds) Shape-Memory Polymers. Advances in Polymer Science, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2009_23

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