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Migration of Monomeric and Polymeric PVC Plasticizers

  • Minna HakkarainenEmail author
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 211)

Abstract

This paper summarizes current literature on the migration of monomeric and polymeric PVC plasticizers from medical materials, food packaging, and toys. Especially highlighted is macromolecular engineering as a tool to increase the plasticizing efficiency and migration resistance for polymeric plasticizers. The effect of branching, molecular weight, end-group functionality, and polydispersity on plasticizer performance was evaluated by quantification of low-molecular-weight hydrolysis products, measurements of mechanical properties, weight loss, surface segregation, as well as the preservation of material properties during aging. A more migration-resistant polymeric plasticizer that also better preserved its material properties during aging was obtained by combining a low degree of branching, hydrolysis-protecting end-groups, and higher molecular weight.

Migration Phthalate Plasticizer Poly(butylene adipate) Poly(vinyl chloride)  

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References

  1. 1.
    Rahman M, Brazel CS (2004) Prog Polym Sci 29:1223 CrossRefGoogle Scholar
  2. 2.
    Tullo AH (2005) Chem Eng News 83:29 Google Scholar
  3. 3.
    Jaeger RJ, Rubin RJ (1972) New Engl J Med 287:1114 CrossRefGoogle Scholar
  4. 4.
    Jaeger RJ, Rubin RJ (1970) Science 170:460 CrossRefGoogle Scholar
  5. 5.
    Latini G, De Felice C, Verrotti A (2004) Reprod Toxicol 19:27 CrossRefGoogle Scholar
  6. 6.
    Koch HM, Drexler H, Angerer J (2003) Int J Hyg Environ Health 206:77 CrossRefGoogle Scholar
  7. 7.
    Krauskopf LG (2003) J Vinyl Addit Technol 9:159 CrossRefGoogle Scholar
  8. 8.
    Messori M, Toselli M, Pilati F, Fabbri E, Fabbri P, Pasquali L, Nannarone S (2004) Polymer 45:805 CrossRefGoogle Scholar
  9. 9.
    Lee JH, Kim KO, Ju Ym (1999) J Biomed Mater Res 48:328 Google Scholar
  10. 10.
    Lakshmi S, Jayakrishnan A (1998) Artif Organs 22:222 CrossRefGoogle Scholar
  11. 11.
    Bourdeaux D, Sautou-Miranda V, Bagel-Boithias S, Boyer A, Chopineau J (2004) J Pharmaceut Biomed 35:57 CrossRefGoogle Scholar
  12. 12.
    Di Landro L, Capone C, Inzoli F, Malacari PE (2005) J Vinyl Addit Techn 11:111 CrossRefGoogle Scholar
  13. 13.
    Jayakrishnan A, Sunny MC (1996) Polymer 37:5213 CrossRefGoogle Scholar
  14. 14.
    Jayakrishnan A, Lakshmi S (1998) Nature 396:638 CrossRefGoogle Scholar
  15. 15.
    Ito R, Seshimo F, Haishima Y, Hasegawa C, Isama K, Yagami T, Nakahashi K, Yamazaki H, Inoue K, Yoshimura Y, Saito K, Tsuchiya T, Nakazawa H (2005) Int J Pharm 303:104 CrossRefGoogle Scholar
  16. 16.
    Hubbell DS, Cooper SL (1977) J Appl Polym Sci 21:3035 CrossRefGoogle Scholar
  17. 17.
    Chiu F-C, Min K (2000) Polym Int 49:223 CrossRefGoogle Scholar
  18. 18.
    Coleman MM, Zarian J (1979) J Polym Sci Polym Phys 17:837 CrossRefGoogle Scholar
  19. 19.
    Prud'homme RE (1982) Polym Eng Sci 22:90 Google Scholar
  20. 20.
    Clark MBJ, Burkhardt CA, Gardella JAJ (1991) Macromolecules 24:799 CrossRefGoogle Scholar
  21. 21.
    Karal O, Hamurcu EE, Baysal BM (1997) Polymer 38:6071 CrossRefGoogle Scholar
  22. 22.
    Choe S, Cha Y-J, Lee H-S, Yoon JS, Choi H (1995) J Polym 36:4977 CrossRefGoogle Scholar
  23. 23.
    Ziska JJ, Barlow JW, Paul DR (1981) Polymer 22:918 CrossRefGoogle Scholar
  24. 24.
    Oriol-Hemmerlin C, Pham QT (2000) Polymer 41:4401 CrossRefGoogle Scholar
  25. 25.
    Lee S, Lee JG, Lee H, Mumby SJ (1999) Polymer 40:5137 CrossRefGoogle Scholar
  26. 26.
    Castle L, Mercer AJ, Gilbert J (1991) Food Addit Contam 8:565 Google Scholar
  27. 27.
    Hakkarainen M (2003) J Chromatogr A 1010:9 CrossRefGoogle Scholar
  28. 28.
    Hakkarainen M (2003) Polym Degrad Stab 80:451 CrossRefGoogle Scholar
  29. 29.
    Ferruti P, Mancin I, Ranucci E, De Felice C, Latini G, Laus M (2003) Biomacromolecules 4:181 CrossRefGoogle Scholar
  30. 30.
    Garton A (1983) Polym Eng Sci 23:663 CrossRefGoogle Scholar
  31. 31.
    Garton A, Aubin M, Prud'homme RE (1983) J Polym Sci Polym Lett 21:45 Google Scholar
  32. 32.
    Garton A, Cousin P, Prud'homme RE (1983) J Polym Sci Polym Phys 21:2275 Google Scholar
  33. 33.
    Varnell DF, Moskala EJ, Painter PC, Coleman MM (1983) Polym Eng Sci 23:658 CrossRefGoogle Scholar
  34. 34.
    Han YK, Um JW, Im SS, Kim BC (2001) J Polym Sci Polym Chem 39:2143 CrossRefGoogle Scholar
  35. 35.
    Kim YH, Webster OW (1992) Macromolecules 25:5561 CrossRefGoogle Scholar
  36. 36.
    Massa DJ, Shriner KA, Turner SR, Voit BI (1995) Macromolecules 28:3214 CrossRefGoogle Scholar
  37. 37.
    Huber CF, Foulks HCJ, Aylesworth RD (1967) US Patent 3331802 Google Scholar
  38. 38.
    Choi J, Kwak S-Y (2004) PMSE Preprints 90:449 Google Scholar
  39. 39.
    Kwak S-Y, Choi J-S (2004) US Patent 6747092 Google Scholar
  40. 40.
    Lindström A, Hakkarainen M (2006) J Appl Polym Sci 100:2180 CrossRefGoogle Scholar
  41. 41.
    Lindström A, Hakkarainen M (2007) J Appl Polym Sci 104:2458 CrossRefGoogle Scholar
  42. 42.
    Lindström A, Hakkarainen M (2007) J Polym Sci Polym Phys 45:1552 CrossRefGoogle Scholar
  43. 43.
    Lindström A, Hakkarainen M (2007) Biomacromolecules 8:1187 CrossRefGoogle Scholar
  44. 44.
    Clausen PA, Hansen V, Gunnarsen L, Afshari A, Wolkoff P (2004) Environ Sci Technol 38:2531 CrossRefGoogle Scholar
  45. 45.
    Wensing M, Uhde E, Salthammer T (2005) Sci Total Environ 339:19 CrossRefGoogle Scholar
  46. 46.
    Arbin A, Jacobsson S, Hänninen K, Hagman A, Östelius J (1986) Int J Pharmac 28:211 CrossRefGoogle Scholar
  47. 47.
    Inoue K, Higuchi T, Okada F, Iguchi H, Yoshimura Y, Sato A, Nakazawa H (2003) J Pharmacol Biomed Anal 31:1145 CrossRefGoogle Scholar
  48. 48.
    Inoue K, Kawaguchi M, Yamanaka R, Higuchi T, Ito R, Saito K, Nakazawa H (2005) Clin Chim Acta 385:159 CrossRefGoogle Scholar
  49. 49.
    Zygoura PD, Paleologos EK, Riganakos KA, Kontominas MG (2005) J Chromatogr A 1093:29 CrossRefGoogle Scholar
  50. 50.
    Lakshmi S, Jayakrishnan A (1998) Artif Org 22:222 CrossRefGoogle Scholar
  51. 51.
    Ezerskis Z, Morkunas V, Suman M, Simoneau C (2007) Anal Chim Acta 604:29 CrossRefGoogle Scholar
  52. 52.
    Frankhauser-Noti A, Grob K (2006) Trends Food Sci Technol 17:105 CrossRefGoogle Scholar
  53. 53.
    Goulas AE, Anifantaki KI, Kolioulis DG, Kontominas MG (2000) J Dairy Sci 83:1712 CrossRefGoogle Scholar
  54. 54.
    Petersen JH, Naamansen ET, Nielsen PA (1995) Food Addit Contam 12:245 Google Scholar
  55. 55.
    Startin JR, Sharman M, Rose MD, Parker I, Mercer AJ, Castle L, Gilbert J (1987) Food Addit Contam 4:385-398 Google Scholar
  56. 56.
    Castle L, Mercer AJ, Startin JR, Gilbert J (1987) Food Addit Contam 4:399 Google Scholar
  57. 57.
    Castle L, Mercer AJ, Startin JR, Gilbert J (1988) Food Addit Contam 5:9 Google Scholar
  58. 58.
    Goulas AE, Zygoura P, Karatapanis A, Georgantelis D, Konominas MG (2007) Food Chem Toxicol 45:585 CrossRefGoogle Scholar
  59. 59.
    Kondyli E, Panagiotis Demertzis G, Kontominas MG (1992) Food Chem 45:163 CrossRefGoogle Scholar
  60. 60.
    Castle L, Gilbert J, Eklund T (1990) Food Contam Addit 7:591 Google Scholar
  61. 61.
    Choudhry MS, Lox F, Buekens A, Decroly P (1998) Packag Technol Sci 11:275 CrossRefGoogle Scholar
  62. 62.
    Loyo-Rosales JE, Rosales-Rivera GC, Lynch AM, Rice CP, Torrents A (2004) J Agric Food Chem 52:2016 CrossRefGoogle Scholar
  63. 63.
    Inoue K, Kondo S, Yoshie Y, Kato K, Yoshimura Y, Horie M, Nakazawa H (2001) Food Addit Contam 18:157 CrossRefGoogle Scholar
  64. 64.
    Goulas AE, Kokkinos A, Kontominas MG (1995) Z Lebensm Unters Forsch 201:74 CrossRefGoogle Scholar
  65. 65.
    Zygoura PD, Goulas AE, Riganakos KA, Kontominas MG (2007) J Food Eng 78:870 CrossRefGoogle Scholar
  66. 66.
    Goulas AE, Kontominas MG (1996) Z Lebensm Unters Forsch 202:250 CrossRefGoogle Scholar
  67. 67.
    Marín ML, López J, Sánchez A, Vilaplana J, Jiménez A (1998) Bull Environ Contam Toxicol 60:68 CrossRefGoogle Scholar
  68. 68.
    Stringer R, Labunska I, Santillo D, Johnston P, Siddorn J, Stephenson A (2000) Environ Sci Pollut Res 7:27 CrossRefGoogle Scholar
  69. 69.
    Steiner I, Scharf L, Fiala F, Washuttl J (1998) Food Addit Contam 15:812 Google Scholar
  70. 70.
    Bouma K, Schakel DJ (2002) Food Addit Contam 19:602 CrossRefGoogle Scholar
  71. 71.
    Earls AO, Axford IP, Braybrook JH (2003) J Chromatogr A 983:237 CrossRefGoogle Scholar
  72. 72.
    Koch HM, Drexler H, Angerer J (2004) Int J Hyg Environ Health 207:15 CrossRefGoogle Scholar
  73. 73.
    Ticker JA, Schettler T, Guidotti T, McCally M, Rossi M (2001) Am J Ind Med 39:100 CrossRefGoogle Scholar
  74. 74.
    Williams DF, de Jong W, Thomsen M, Rodriguez Farre E, Gatti Am, Paunio MK, Hensten Petersen A, Marquardt H (2002) European Commission Health & Consumer protection directorate-general. Opinion on Medical Devices Containing DEHP Plasticised PVC; Neonates and Other Groups Possibly at Risk from DEHP toxicity. Scientific Committee on Medical Products and Medical Devices of the European Committee. Doc.Sanco/Scmpmd/2002/0010:Final.2002 Google Scholar
  75. 75.
    Hill SS, Shaw BR, Wu AHB (2001) Clin Chim Acta 304:1 CrossRefGoogle Scholar
  76. 76.
    Latini G, De Felice C, Presta G, Del Vecchio A, Paris I, Ruggieri F, Mazzeo P (2003) Environ Health Persp 111:1783 CrossRefGoogle Scholar
  77. 77.
    Kleinsasser NH, Harreus UA, Kastenbauer ER, Wallner BC, Sassen AW, Staudenmaier R, Rettenmeier AW (2004) Toxicol Lett 148:83 CrossRefGoogle Scholar
  78. 78.
    French Ministry of the Environment, French Ministry of Health and F. M. o. Work (2003) Risk Assessment of 1,2-Benzenedicarboxylic Acid, Di-C8-10-Branched Alkyl Esters C9-Rich, and Di-Isononyl Phthalate (DINP). European Chemicals Bureau, Ispra, Italy Google Scholar
  79. 79.
    Lee MH, Park J, Chung SW, Kang BY, Kim SH, Kim TS (2004) Int Arch Allergy Imm 134:213 CrossRefGoogle Scholar
  80. 80.
    Byrne D (1999) The Commission of the European Communities, Commission Decision 1999/815/EC, Official Journal of the European Communities, L315/46 Google Scholar
  81. 81.
    The European Parliament and the European Council (2005) Directive 2005/84/EC of the European Parliament and the Council. Official J Eur Communities L344:40 Google Scholar
  82. 82.
    Vesterberg A, Hedenmark M, Vass A-M (2005) PVC in Medical Devices. An Inventory of PVC and Phthalates Containing Devices Used in Health Care; Department of the Environment and Sustainability. Karolinska University Hospital, Solna, Stockholm Google Scholar
  83. 83.
    Castle L, Nichol J, Gilbert J (1993) Food Addit Contam 10:523 Google Scholar
  84. 84.
    Audic JL, Reyx D, Brosse JC (2003) J Appl Polym Sci 89:1291 CrossRefGoogle Scholar
  85. 85.
    Thomas NL (2004) J Appl Polym Sci 94:2022 CrossRefGoogle Scholar
  86. 86.
    Rushton BM, Salomons NS (1969) J Appl Polym Sci 13:2341 CrossRefGoogle Scholar
  87. 87.
    Wang Q, Storm BK (2005) Macromol Symp 225:191 CrossRefGoogle Scholar
  88. 88.
    Castle L, Mercer AJ, Gilbert J (1988) Food Addit Contam 5:277 Google Scholar
  89. 89.
    Castle L, Nichol J, Gilbert J (1993) Food Addit Contam 10:523 Google Scholar
  90. 90.
    Hamdani M, Thil L, Gans G, Feigenbaum AE (2002) J Appl Polym Sci 83:956 CrossRefGoogle Scholar
  91. 91.
    Choi J, Kwak S-Y (2007) Environ Sci Technol 41:3763 CrossRefGoogle Scholar
  92. 92.
    Lindström A, Albertsson A-C, Hakkarainen M (2004) J Chromatogr A 1022:171 CrossRefGoogle Scholar
  93. 93.
    Lindström A, Albertsson A-C, Hakkarainen M (2004) Polym Degrad Stab 83:487 CrossRefGoogle Scholar
  94. 94.
    Hirschlag H, Koster R (1998) Fresenius J Anal Chem 362:274 CrossRefGoogle Scholar
  95. 95.
    Canavate J, Pages P, Rodriguez MJ, Perez-Folch J, Carrasco F, Colom X (2001) J Polym Mater 18:33 Google Scholar
  96. 96.
    Forrey C, Koberstein JT, Pan DH (2003) Interface Sci 11:211 CrossRefGoogle Scholar
  97. 97.
    Brown DW, Lowry RE, Smith LE (1980) Macromolecules 13:248 CrossRefGoogle Scholar
  98. 98.
    Huffman KR, Casey DJ (1985) J Polym Sci Polym Chem 23:1939 Google Scholar
  99. 99.
    Pitt CG, Gu ZW (1987) J Control Release 4:283 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  1. 1.Department of Fibre and Polymer Technology, School of Chemical Science and EngineeringRoyal Institute of Technology (KTH)StockholmSweden

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