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Polymers for Regenerative Medicine pp 171–190Cite as

Interfaces to Control Cell-Biomaterial Adhesive Interactions

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 203))

Abstract

Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices, biological integration of biomaterials and tissue-engineered constructs, and the performance of biosensors, cell-based arrays, and biotechnological cell-culture supports. This review focuses on interfaces controlling cell-adhesive interactions, with particular emphasis on surfaces controlling protein adsorption, biomimetic substrates presenting bioadhesive motifs, and micropatterned surfaces to engineer adhesive areas. These approaches represent promising strategies to engineer cell-material biomolecular interactions in order to elicit specific cellular responses and enhance the biological performance of materials in biomedical and biotechnological applications.

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Abbreviations

COL-I:

Type I collagen

ECM:

Extracellular matrix

ELISA:

Enzyme-linked immunosorbent assay

FN:

Fibronectin

GFOGER:

Glycine-phenylalanine-hydroxyproline-glycine-glutamate-arginine

LN:

Laminin

PEG:

Poly(ethelyne glycol)

RGD:

Arginine-glycine-aspartic acid

SAM:

Self-assembled monolayers

YIGSR:

Tyrosine-isoleucine-glycine-serine-arginine

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Acknowledgments

AJG gratefully acknowledges support from the National Science Foundation, National Institutes of Health, Arthritis Foundation, Whitaker Foundation, and the Georgia Tech/Emory NSF ERC on Engineering Living Tissues.

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Authors and Affiliations

  1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, IBB 2314, 30332-0363, Atlanta, GA, USA

    Andrés J. García

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  1. Andrés J. García
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Correspondence to Andrés J. García .

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Carsten Werner

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García, A.J. Interfaces to Control Cell-Biomaterial Adhesive Interactions. In: Werner, C. (eds) Polymers for Regenerative Medicine. Advances in Polymer Science, vol 203. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_071

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