Photoiniferter-Driven Precision Surface Graft Microarchitectures for Biomedical Applications
- 459 Downloads
The photoiniferter polymerization method proposed by Otsu et al. was utilized to generate well-controlled graft polymer chains on a surface. The “livingness” of graft chains, coupled with the inherent nature of photochemical processing, enables the development of complex graft-polymerized surface designs with controlled graft-chain length and composition, regiospecific addressability and high-dimensional precision. As an extension of the advantageous features of the “quasi-living” nature of polymerization, precise control technology for surface graft-chain architectures, which show multibranching, a fractal hierarchy and a gradient segmental density, was elaborated. The logical programmed morphogenesis approach was discussed, and a high degree of graft-chain architectures was demonstrated as if these resemble the spatiogeometric analogue models of growing trees with diverse morphologies. The confocal laser scanning microscopic measurement for dye-stained grafted surfaces and the force–distance curves of atomic force microscopy provided some physicochemical and structural insights into graft architectures. Under appropriate conditions, the cross-recommendation reaction of two different dithiocarbamate derivatives enabled the development of a novel surface derivatization method. Microprocessed surfaces with multigraft polymers in different regions and with different chain lengths enabled differentiation of regiospecific cell adhesion and proliferation potentials and cellular functions in one sample, which provides high-throughput screening for the biocompatibility of designed medical devices.
Unable to display preview. Download preview PDF.
This review article is dedicated to Dr. Takayuki Ohtsu (Professor Emeritus, Osaka City University) who pioneered photoiniferter polymerization. A large number of studies by his research group stimulated and directed me to conduct a series of surface microarchitecture studies focusing on biomedical applications. The author also appreciates Professor Rainer Jordan, volume editor of this special issue, who carefully edited this article with patience.
- 1.Ratner BD, Hoffman AF, Schoen FJ, Lemons JE (1996) Biomaterials Science: an Introduction to Materials in Medicine. Academic, New York, p 193 Google Scholar
- 2.Andrade JD (1985) Polymer Surface Dynamics, Vol. 1.Plenum, New York Google Scholar
- 3.Kim SW, Jacobs H (1996) Blood Purif 14:357–362 Google Scholar
- 7.Otsu T, Yoshida M, Tazaki T (1982) Rapid Commun 3:133–40 Google Scholar
- 8.Otsu T, Yaoshida M (1982) Rapid Commun 3:127–32 Google Scholar
- 12.Bowman NC, Anseth SK, Luo N, Lovell GL, Lu H (2001) Polym Mater Eng 85–156 Google Scholar
- 18.Zaremski YM, Chernikova VE, Izmailov GL, Garina SE, Olenin VA (1996) Macromol Rep A 33:237–242 Google Scholar
- 19.Zarenskii YM, Olenin VA (1991) Zh Prikl Khim 64:2145–2149 Google Scholar
- 28.Kidoaki S, Nakayama Y, Matsuda T (2001) Langmuir 17:10870–10872 Google Scholar
- 40.Nakamata K (1998) MS Dissertation, Osaka Institute of Technology. Matsuda T, Nakamata K, Hirano J, Nakayama Y (in contribution) Google Scholar