Photoiniferter-Driven Precision Surface Graft Microarchitectures for Biomedical Applications

  • Takehisa MatsudaEmail author
Part of the Advances in Polymer Science book series (POLYMER, volume 197)


The photoiniferter polymerization method proposed by Otsu et al. was utilized to generate well-controlled graft polymer chains on a surface. The “livingness” of graft chains, coupled with the inherent nature of photochemical processing, enables the development of complex graft-polymerized surface designs with controlled graft-chain length and composition, regiospecific addressability and high-dimensional precision. As an extension of the advantageous features of the “quasi-living” nature of polymerization, precise control technology for surface graft-chain architectures, which show multibranching, a fractal hierarchy and a gradient segmental density, was elaborated. The logical programmed morphogenesis approach was discussed, and a high degree of graft-chain architectures was demonstrated as if these resemble the spatiogeometric analogue models of growing trees with diverse morphologies. The confocal laser scanning microscopic measurement for dye-stained grafted surfaces and the force–distance curves of atomic force microscopy provided some physicochemical and structural insights into graft architectures. Under appropriate conditions, the cross-recommendation reaction of two different dithiocarbamate derivatives enabled the development of a novel surface derivatization method. Microprocessed surfaces with multigraft polymers in different regions and with different chain lengths enabled differentiation of regiospecific cell adhesion and proliferation potentials and cellular functions in one sample, which provides high-throughput screening for the biocompatibility of designed medical devices.

Biomedical application Iniferter Living polymerization Surface graft architecture 


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This review article is dedicated to Dr. Takayuki Ohtsu (Professor Emeritus, Osaka City University) who pioneered photoiniferter polymerization. A large number of studies by his research group stimulated and directed me to conduct a series of surface microarchitecture studies focusing on biomedical applications. The author also appreciates Professor Rainer Jordan, volume editor of this special issue, who carefully edited this article with patience.


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Authors and Affiliations

  1. 1.Division of Biomedical EngineeringGraduate School of Medicine, Kyushu UniversityHigashi-ku, FukuokaJapan

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