Abstract
Homogeneous catalytic asymmetric hydrogenation has evolved into a significantly useful methodology for the prepartion of enantiopure compounds. Significant advances in asymmetric hydrogenation of imines have enabled a straightforward and powerful approach to various chiral amines. An overview of the many variants of the chiral transition metal catalysts, illustrations of synthetic applications, and discussions of emerging and future strategies from a mechanistic perspective are presented.
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Abbreviations
- BARF:
-
(Tetrakis(3,5-bis(trifluoromethyl)phenyl)borate)
- COD:
-
Cyclooctadiene
- Cp:
-
Cyclopentadienyl
- Cp*:
-
1,2,3,4,5-Pentamethylcyclopentadienyl
- DCE:
-
Dichloroethane
- D-DTTA:
-
Di-p-toluoyl-d-tartaric acid
- DPEN:
-
1,2-Diphenylethane-1,2-diamine
- MEA:
-
2-Methyl-5-ethylaniline
- Py:
-
Pyridine
- SPO:
-
Secondary phosphine oxide
- TBME:
-
tert-Butyl methyl ether
- TFE:
-
Trifluoroethanol
- THF:
-
Tetrahydrofuran
- TMI:
-
2,3,3-Trimethylindolenine
- TOF:
-
Turnover frequency
- TON:
-
Turnover number
- Ts:
-
Tosyl (p-CH3C6H4SO2)
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Li, W., Zhang, X. (2013). Asymmetric Hydrogenation of Imines. In: Li, W., Zhang, X. (eds) Stereoselective Formation of Amines. Topics in Current Chemistry, vol 343. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2013_483
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