Abstract
N-Heterocycles, including fused ones, have proven to be an important class of compounds since they possess biological and pharmacological activities themselves and serve as valuable intermediates for synthetic drug discovery. My interest in the synthesis of these compounds stems from studies dealing with the hydroformylation (oxo) of olefins. The dihydroindolizines and benzofused ones are easily generated via rhodium-catalyzed hydroformylation of N-allylpyrroles and indoles: the butanal intermediate undergoes an intramolecular cyclodehydration giving the final polycyclic compound. This chapter reports my results in the area of the conversions of oxo aldehydes with additional C,C-bond-forming reactions together with relevant work from other laboratories on additional C,N-bond-forming reactions, encountered in the field of Azapolycycles synthesis over the last 5 years or so. The intramolecular sequences for polycylization will be especially emphasized using rhodium complexes to effect these transformations, under both conventional and microwave heating.
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References
Kouznetsov V, Palma A, Ewert C (2001) Synthesis and applicability of partially reduced 2-benzazepines. Curr Org Chem 5:519–551
Yea CM, Allan CE, Ashworth DM, Barnett J, Baxter AJ, Broadbridge JD, Franklin RJ, Hampton SL, Hudson P, Horton JA, Jenkins PD, Penson AM, Pitt GRW, Rivière P, Robson PA, Rooker DP, Semple G, Sheppard A, Haigh RM, Roe MB (2008) New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem 51:8124–8134
Katritzky A, Rees CW, Scriven EF (eds) (1996) Comprehensive heterocyclic chemistry. Elsevier, Oxford
Gilchrist TL (1997) Heterocyclic chemistry, 3rd edn. Addison Wesley, Essex, p 414
Nakamura I, Yamamoto Y (2004) Transition-metal-catalyzed reactions in heterocyclic synthesis. Chem Rev 104:2127–2198
Cacchi S, Fabrizi G (2005) Synthesis and functionalization of indoles through palladium-catalyzed reactions. Chem Rev 105:2873–2920
Zeni G, Larock RC (2006) Synthesis of heterocycles via palladium-catalyzed oxidative addition. Chem Rev 106:4644–4680
Conreaux D, Bouyssi D, Monteiro N, Balme G (2006) Palladium-catalyzed bicyclization processes in the one step construction of heteropolycyclic ring systems. Curr Org Chem 10:1325–1340
Varchi G, Ojima I (2006) Synthesis of heterocycles through hydrosilylation, silylformylation, silylcarbocyclization and cyclohydrocarbonylation react. Curr Org Chem 10:1341–1362
Negishi E-I (ed) (2002) Handbook of organopalladium chemistry for organic synthesis. Wiley, Weinheim
Balme G, Bossharth E, Monteiro N (2003) Pd-assisted multicomponent synthesis of heterocycles. Eur J Org Chem 21:4101–4111
Balme G (2004) Pyrrolsynthese durch Mehrkomponenten–Kupplungen. Angew Chem 116:6396–6399
Balme G (2004) Pyrrole syntheses by multicomponent coupling reactions. Angew Chem Int Ed 43:6238–6241
Eilbracht P, Schmidt AM (2002) New synthetic applications of tandem reactions under hydroformylation conditions. In: Beller M, Bolm C (eds) Transition metals for organic synthesis. Wiley, Weinheim, pp 57–85
Breit B (2003) Synthetic aspects of stereoselective hydroformylation. Acc Chem Res 36:264–275
Eilbracht P, Schmidt AM (2006) Synthetic applications of tandem reaction sequences involving hydroformylation. Top Organomet Chem 18:65–95
Frohning CD, Kohlpainter CW(1996) In: Cornils B, Herrmann WA (eds) Applied homogeneous catalysis with organometallic compounds, vol 1.Wiley, Weinheim, p 29
Kalck P, Peres Y, Jenck J (1991) Hydroformylation catalyzed by ruthenium complexes. Adv Organomet Chem 32:121–146
van Leeuwen PWNM, Claver C (eds) (2000) Catalysis by metal complexes. Rhodium catalyzed hydroformylation, vol 22. Kluwer, Dordrecht
Evans D, Osborn JA, Wilkinson G (1968) Hydroformylation of alkenes by use of rhodium complex catalysts. J Chem Soc A 3133–3142
Ungvary F (2003) Application of transition metals in hydroformylation annual survey covering the year 2002. Coord Chem Rev 241:295–312
Grushin VV (2004) Mixed phosphine−phosphine oxide ligands. Chem Rev 104:1629–1662
Cuny GD, Buchwald SL (1993) Practical, high-yield, regioselective, rhodium-catalyzed hydroformylation of functionalized alpha-olefins. J Am Chem Soc 115:2066–2068
Bronger RPJ, Kamer PCJ, van Leeuwen PWNM (2003) Influence of the bite angle on the hydroformylation of internal olefins to linear aldehydes. Organometallics 22:5358–5369
Selent D, Wiese KD, Röttger D, Börner A (2000) Novel oxyfunctionalized phosphonite ligands for the hydroformylation of isomeric n-olefins. Angew Chem Int Ed 39:1639–1641
Gual A, Godard C, Castillón S, Claver C (2010) Highlights of the Rh-catalysed asymmetric hydroformylation of alkenes using phosphorus donor ligands. Tetrahedron Asymmetry 21:1135–1146
Aubry DA, Bridges NN, Ezell K, Stanley GG (2003) Polar phase hydroformylation: the dramatic effect of water on mono- and dirhodium catalysts. J Am Chem Soc 125:11180–11181
Li C, Widjaja E, Garland M (2003) The Rh4(CO)12-catalyzed hydroformylation of 3,3-dimethylbut-1-ene promoted with HMn(CO)5. Bimetallic catalytic binuclear elimination as an origin for synergism in homogeneous catalysis. J Am Chem Soc 125:5540–5548
Kim JJ, Alper H (2005) Ionic diamine rhodium(I) complexes-highly active catalysts for the hydroformylation of olefins. Chem Commun 3059–3061
Amer I, Alper H (1990) Zwitterionic rhodium complexes as catalysts for the hydroformylation of olefins. J Am Chem Soc 112:3674–3676
Lazzaroni R, Settambolo R, Caiazzo A (2000) Hydroformylation with unmodified rhodium catalysts. In: van Leeuwen PVNM, Claver C (eds) Catalysis by metal complexes. Rhodium catalyzed hydroformylation, vol 22. Kluwer, Dordrecht, pp 15–33
Thatchenko I (1982) In: Wilkinson G, Stone FGA, Abel EW (eds) Comprehensive organometallic chemistry. Pergamon, Oxford, p 101
Beller M, Bolm C (eds) (1999) Transition metals for organic synthesis. Wiley, Weinheim
Garland M, Pino P (1991) Kinetics of the formation and hydrogenolysis of acylrhodium tetracarbonyl. Organometallics 10:1693–1704
Garland M (1993) Heterometallic clusters as catalyst precursors. Synergism arising from the facile generation of a reactive fragment. Organometallics 12:535–543
Fyhr C, Garland M (1993) Phenomenological aspects of homogeneous catalysis. The case of equilibrium-controlled precursor conversion. Organometallics 12:1753–1764
Feng J, Garland M (1999) Unmodified homogeneous rhodium-catalyzed hydroformylation of styrene. The detailed kinetics of the regioselective synthesis. Organometallics 18:417–427
Liu G, Volken R, Garland M (1999) Unmodified rhodium-catalyzed hydroformylation of alkenes using tetrarhodium dodecacarbonyl. The infrared characterization of 15 acyl rhodium tetracarbonyl intermediates. Organometallics 18:3429–3436
Lazzaroni R, Raffaelli A, Settambolo R, Bertozzi S, Vitulli G (1989) Regioselectivity in the rhodium-catalyzed hydroformylation of styrene as a function of reaction temperature and gas pressure. J Mol Catal 50:1–9
Kalck P, Serein-Spiran F (1989) Easy synthesis of phenyl- and furylpropanals by low pressure hydroformylation of styrene and 2-vinylfuran. New J Chem 13:515–518
Browning AF, Bacon AD, White C, Milner DJ (1993) The beneficial effects of introducing sulfur substituents into hydroformylation substrates. J Mol Catal 83:L11–L14
Caiazzo A, Settambolo R, Uccello-Barretta G, Lazzaroni R (1997) Influence of the reaction temperature on the regioselectivity in the rhodium-catalyzed hydroformylation of vinylpyrroles. J Organomet Chem 548:279–284
Lazzaroni R, Settambolo R, Mariani M, Caiazzo A (1999) Stepwise hydroformylation of C,N-divinylpyrroles with Rh4(CO)12 under mild conditions: an original synthesis of N-vinylpyrrolylmonoaldehydes and of pyrrolyldialdehydes. J Organomet Chem 592:69–73
Basoli C, Botteghi C, Cabras MA, Chelucci G, Marchetti M (1995) Hydroformylation of some functionalized olefins catalyzed by rhodium(I) complexes with pydiphos and its P-oxide. J Organomet Chem 488:C20–C22
Settambolo R, Scamuzzi S, Caiazzo A, Lazzaroni R (1998) Opposite chemoselectivity (hydrogenation versus carbonylation) shown by 4-vinylpyridine with respect to 3-vinylpyridine under hydroformylation conditions with Rh4(CO)12. Organometallics 17:2127–2130
Caiazzo A, Settambolo R, Pontorno L, Lazzaroni R (2000) Chemoselectivity in the rhodium-catalyzed hydroformylation of 4-vinylpyridine: crucial role of phosphine ligand in promoting carbonylation instead of hydrogenation. J Organomet Chem 599:298–303
Hanson BE, Davis NE (1987) Hydroformylation of 1-hexene utilizing homogeneous rhodium catalysts regioselectivity as a function of conversion. J Chem Educ 64:928–930
Lazzaroni R, Pertici P, Bertozzi S, Fabrizi G (1990) 1-Hexene rhodium-catalyzed hydroformylation at partial substrate conversion: influence of reaction parameters on the chemoselectivity and regioselectivity. J Mol Catal 58:75–85
Wender I, Pino P (eds) (1977) Organic syntheses via metal carbonyls, vol 2. Wiley, New York
Lazzaroni R, Settambolo R, Uccello-Barretta G, Caiazzo A, Scamuzzi S (1999) Rhodium-catalyzed hydroformylation of vinylidenic olefins: the different behaviors of the isomeric alkyl-metal intermediates as the origin of the β-regioselectivity. J Mol Catal A Chem 143:123–130
Botteghi C, Cazzolato L, Marchetti M, Paganelli S (1995) New synthetic route to pharmacologically active 1-(N, N-dialkylamino)-3,3-diarylpropanes via rhodium-catalyzed hydroformylation of 1,1-diarylethenes. J Org Chem 60:6612–6615
Lazzaroni R, Settambolo R, Caiazzo A (2000) Hydroformylation with unmodified rhodium catalysts. In: van Leeuwen PVNM, Claver C (eds) Catalysis by metal complexes. Rhodium catalyzed hydroformylation. Kluwer, Dortrecht, pp 15–33
Garst ME, Lukton D (1981) Hydroformylation of bisolefinic amine derivatives catalyzed by cobalt and rhodium. J Org Chem 46:4433–4438
dos Santos EN, Pittman CU Jr, Toghiani H (1993) Hydroformylation of α- and β-pinene catalysed by rhodium and cobalt carbonyls. J Mol Catal 83:51–65
Banach D, Evans GO II, Mcintyre DG, Predmore T, Richmond MG, Supple HJ, Stewart RP Jr (1985) Rhodium-catalyzed hydroformylations of unsaturated nitrogen heterocycles: regio- and stereoselectivity in the synthesis of tropane and pdperidine carboxaldehydes. J Mol Catal 31:15–37
Botteghi C, Paganelli S, Perosa A, Lazzaroni R, Uccello-Barretta G (1993) Hydroformylation of norbornene and 2,5-norbornadiene catalysed by platinum(0)-alkene complexes in the presence of methanesulfonic acid: determination of the stereochemistry of the reaction. J Organomet Chem 447:153–157
Becker Y, Eisenstadt A, Stille JK (1980) Asymmetric hydroformylation and hydrocarboxylation of enamides. Synthesis of alanine and proline. J Org Chem 45:2145–2151
Cavinato G, Toniolo L, Botteghi C, Gladiali S (1982) Hydrocarboalkoxylation of N-vinylphthalimide catalyzed by palladium complexes. J Organomet Chem 229:93–100
Delogu G, Fredda G, Gladiali S (1984) Hydrocarbonylation of unsaturated nitrogen compounds. Synthesis of N-protected amino acid derivatives from N-substituted phthalimides. J Organomet Chem 268:167–174
Parriniello G, Stille JK (1987) Asymmetric hydroformylation catalyzed by homogeneous and polymer-supported platinum complexes containing chiral phosphine ligands. J Am Chem Soc 109:7122–7127
Botteghi C, Paganelli S, Schiodato A, Marchetti M (1991) The asymmetric hydroformylation in the synthesis of pharmaceuticals. Chirality 3:355–369
Gladiali S, Bayòn JC, Claver C (1995) Recent advances in enantioselective hydroformylation. Tetrahedron Asymmetry 6:1453–1474
Dolphin D (1997) The porphirins. Academic, New York
Lazzaroni R, Settambolo R, Caiazzo A, Pontorno L (2000) Rhodium-catalyzed hydroformylation of 1-allylpyrrole as an unexpected way to 5,6-dihydroindolizine synthesis. J Organomet Chem 601:320–323
Guazzelli G, Settambolo R (2007) 4-Indolylbutanals from rhodium-catalyzed hydroformylation of allylindoles as precursors of benzofused indolizine. Tetrahedron Lett 48:6034–6038
Michael JP (2005) Indolizidine and quinolizidine alkaloids. Nat Prod Rep 22:603–626
Daly JW (2003) Ernest Guenther award in chemistry of natural products. amphibian skin: a remarkable source of biologically active arthropod alkaloids. J Med Chem 46:445–452
Baxter EW, Reitz AB (1994) Expeditious synthesis of aza sugars by the double reductive amination of dicarbonyl sugars. J Org Chem 59:3175–3185
Sinnot LM (1990) Catalytic mechanism of enzymic glycosyl transfer. Chem Rev 90:1171–1202
Shao J, Yang J-S (2012) A diastereoselective cyclic imine cycloaddition strategy to access polyhydroxylated indolizidine skeleton: concise syntheses of (+)-/(−)-lentiginosines and (−)-2-epi-steviamine. J Org Chem 77:7891–7900
Sultane PR, Mohite AR, Bhat RG (2012) Total synthesis of 1-deoxy-7,8a-di-epi-castanospermine and formal synthesis of pumiliotoxin-251D. Tetrahedron Lett 53:5856–5858
Elbein AD, Molyneux RJ (1987) In: Pelletier SW (ed) Alkaloids: chemical and biological perspectives, vol 5. Wiley, New York, pp 1–54
Leclercq S, Braekman JC, Daloze D, Pasteels JM (2000) The defensive chemistry of ants. Prog Chem Org Nat Prod 79:115–229
Angle SR, Kim M (2007) A general approach to 3-n-butyl-5-alkylindolizidines: total synthesis of (−)-indolizidine 195B. J Org Chem 72:8791–8796
Bergauer M, Huebner H, Gmeiner P (2004) Practical ex-chiral-pool methodology for the synthesis of dopaminergic tetrahydroindoles. Tetrahedron 60:1197–1204
Lehmann T, Huebner H, Gmeiner P (2001) Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding. Bioorg Med Chem Lett 11:2863–2866
Lehmann T, Gmeiner P (2000) Synthesis of enantiopure 8-aminomethylindolizines from glutamine by stereoelectronically controlled cationic cyclization. Heterocycles 53:1371–1378
Gracia S, Cazorla C, Métay E, Pellet-Rostaing S, Lemaire M (2009) Synthesis of 3-aryl-8-oxo-5,6,7,8-tetrahydroindolizines via a palladium-catalyzed arylation and heteroarylation. J Org Chem 74:3160–3163
Gmeiner P, Mierau J, Hoefner G (1992) Enantiomerically pure aminoindolizines: bicyclic ergoline analogs with dopamine autoreceptor activity. Arch Pharm 325:57–60
Carry JC, Mignani S (1997) Eur Pat Appl EP 118 321; EP 147 317; EP 124 384
Carry JC, Mignani S (1997) French Appl 2(539):417
Remers WA (1979) The chemistry of antitumor antibiotics. Wiley, New York
Pelletier SW (1983) Alkaloids: chemistry and biological perspectives. Wiley, New York
Basavaiah D, Devendar B, Lenin DV, Satyanarayana T (2009) The Baylis–Hillman bromides as versatile synthons: a facile one-pot synthesis of indolizine and benzofused indolizine frameworks. Synlett 3:411–416
Utsunomiya I, Fuji M, Sato T, Natsume M (1993) Preparation of alkyl-substituted indoles in the benzene portion. Part 9. Synthesis of (1aS, 8bS)-1-tert-butyloxycarbonyl-8-formyl-1, 1a, 2, 8b-tetrahydroazirino[2′, 3′:3, 4]pyrrolo[1, 2-α]indole. Model study for the enantiospecific synthesis of aziridinomitosenes. Chem Pharm Bull 41:854–860
Settambolo R, Caiazzo A, Lazzaroni R (2001) An original approach to 5,6-dihydroindolizines from 1-allylpyrroles by a tandem hydroformylation/cyclization/dehydration sequence. Tetrahedron Lett 42:4045–4048
Settambolo R, Guazzelli G, Mandoli A, Lazzaroni R (2004) (5R)-5-Alkyl-5,6-dihydroindolizines via stereospecific domino hydroformylation/cyclodehydration of (3R)-3-(pyrrol-1-yl)alk-1-enes. Tetrahedron Asymmetry 15:1821–1823
McCleverty JA, Wilkinson G (1966) Dichlorotetracarbonyldirhodium. Inorg Synth 8:211–214
Cattermole PE, Osborne AG (1977) Dodecacarbonyltetrarhodium. Inorg Synth 17:115–117
Beller M, Cornils B, Frohning D, Kohlpaintner CW (1995) Progress in hydroformylation and carbonylation. J Mol Catal A Chem 104:17–85
Settambolo R, Rocchiccioli S, Uccello-Barretta G, Lazzaroni R (2007) Chiral N-allylpyrroles as versatile substrates under rhodium-catalyzed hydroformylation: good regio- and diastereo-selectivity at room temperature and high pressure. Lett Org Chem 4:388–392
Kollár L, Farkas E, Bâtiu J (1997) Synthesis of aryl-butanal isomers by hydroformylation of substituted allylbenzene and propenylbenzene. J Mol Catal A 115:283–288
Abu-Gnim C, Amer I (1996) Phosphine oxides as ligands in the hydroformylation reaction. J Organomet Chem 516:235–243
Raffaelli A, Pucci S, Settambolo R, Uccello-Barretta G, Lazzaroni R (1991) Inter- and intramolecular protium-deuterium exchange in the rhodium-catalyzed deuterioformylation of styrene. Organometallics 10:3892–3898
Uccello-Barretta G, Lazzaroni R, Settambolo R, Salvadori P (1991) The use of 2H NMR in the elucidation of the catalytic pathway of the hydroformylation reaction. J Organomet Chem 417:111–119
Lazzaroni R, Settambolo R, Caiazzo A, Bennett MA (2002) Rhodium-catalyzed hydroformylation of 4-vinylpyridine: 4-ethylpyridine formation via an unusual cleavage of the Rh−C bond by the enolic form of the oxo product. Organometallics 21:2454–2459
Lazzaroni R, Settambolo R, Prota G, Botteghi C, Paganelli S, Marchetti M (2004) Rhodium-catalyzed hydro(deuterio)formylation of vinylidenic olefins containing a phenyl and a pyridyl group: crucial role of the β-hydride elimination in determining regio- and chemoselectivity. Inorg Chim Acta 357:3079–3083
Lazzaroni R, Settambolo R, Marchetti M, Paganelli S, Alagona G, Ghio C (2009) Rhodium-catalyzed deuterioformylation of the ketal-masked β-isophorone: evidence for a tertiary alkyl rhodium intermediate as a precursor of the main reaction product acetaldehyde derivative. Inorg Chim Acta 362:1641–1644
Polniaszek RP, Belmont SE (1990) Enantioselective total syntheses of indolizidine alkaloids 167B and 209D. J Org Chem 55:4688–4693
Daly JW, Myers CW, Whittaker N (1987) Further classification of skin alkaloids from neotropical poison frogs (dendrobatidae), with a general survey of toxic/noxious substances in the amphibian. Toxicon 25:1023–1095
Daly JW, Garraffo HM, Spande TF(1999) Alkaloids from amphibian skins. In: Pelletier SW (ed) Alkaloids: chemical and biological perspectives. Pergamon, Amsterdam, pp 1–161
Chang M-Y, Wu T-C, Ko Y-J (2007) Synthesis of Indolizidine 167B. Heterocycles 71:933–940
Ganapati Reddy P, Baskaran S (2004) Epoxide-initiated cationic cyclization of azides: a novel method for the stereoselective construction of 5-hydroxymethyl azabicyclic compounds and application in the stereo- and enantioselective total synthesis of (+)- and (−)-indolizidine 167B and 209D. J Org Chem 69:3093–3101
Michael JP (2007) Indolizidine and quinolizidine alkaloids. Nat Prod Rep 24:191–222
Lapointe G, Kapat A, Weidner K, Renaud P (2012) Radical azidation reactions and their application in the synthesis of alkaloids. Pure Appl Chem 84:1633–1641
By P, Vagner D, Burtoloso ACB (2012) Total synthesis of (−)-indolizidine 167B via an unusual Wolff rearrangement from an α, β-unsaturated diazaketone. Tetrahedron Lett 53:876–878
Reddy CR, Latha B, Rao NN (2012) Enantioselective access to (−)-indolizidines 167B, 209D, 239AB, 195B and (−)-monomorine from a common chiral synthon. Tetrahedron 68:145–151
Settambolo R, Guazzelli G, Mengali L, Mandoli A, Lazzaroni R (2003) A new class of optically active pyrrole derivatives: (3R)-3-(pyrrol-1-yl)alk-1-enes from d-α-aminoacids. Tetrahedron Asymmetry 14:2491–2493
Rocchiccioli S, Guazzelli G, Lazzaroni R, Settambolo R (2007) Synthesis of 5,6,7,8-tetrahydroindolizines via a domino-type transformation based on the rhodium catalyzed hydroformylation of N-(β-methallyl)pyrroles. J Heterocyclic Chem 44:479–482
Settambolo R, Rocchiccioli S, Lazzaroni R, Alagona G (2006) Complete 1,3-asymmetric induction into 3-methyl-4-(3-acetylpyrrol-1- yl)butanal to 1-acetyl-6-methyl-8-hydroxy-5,6,7,8-tetrahydroindolizine cyclization. Lett Org Chem 3:10–12
Rocchiccioli S, Settambolo R, Lazzaroni R (2005) Domino reaction sequences in the rhodium-catalyzed hydroformylation of 3-acetyl-1-allylpyrrole: a short route to 5,6,7,8-tetrahydroindolizines. J Organomet Chem 690:1866–1870
Alagona G, Ghio C, Rocchiccioli S (2007) Computational prediction of the regio- and diastereoselectivity in a rhodium-catalyzed hydroformylation/cyclization domino process. J Mol Model 13:823–837
Breit B, Seiche W (2001) Recent advances on chemo-, regio- and stereoselective hydroformylation. Synthesis 1:1–36
Settambolo R, Miniati S, Lazzaroni R (2003) One pot hydroformylation/intramolecular aldol condensation reactions of 1-allyl-2-carbonylpyrroles: a new entry into hydroindolizines synthesis. Synth Commun 33:2953–2961
Guazzelli G, Settambolo R, Lazzaroni R (2007) Synthesis of 4-(indol-1-yl)butanals via rhodium-catalyzed hydroformylation of 1-allylindoles. Synth Commun 37:1211–1218
Guida WC, Mathre DJ (1980) Phase-transfer alkylation of heterocycles in the presence of 18-crown-6 and potassium tert-butoxide. J Org Chem 45:3172–3176
Petrini M, Ballini R, Marcantoni E (1988) Amberlyst 15: a practical, mild and selective catalyst for methyl esterification of carboxylic acids. Synth Commun 18:847–853
Thalji RK, Ahrendt KA, Bergman RG, Ellman JA (2005) Annulation of aromatic imines via directed C−H bond activation. J Org Chem 70:6775–6781
Yi CS, Yun SY (2005) Ruthenium-catalyzed intermolecular coupling reactions of arylamines with ethylene and 1,3-dienes: mechanistic insight on hydroamination vs ortho-C−H bond activation. Org Lett 7:2181–2183
Eberle MK (1976) Chemistry of indole. 5-(1-indolyl)-2-pentanone system. J Org Chem 41:633–636
Reppe W, Vetter H (1953) Carbonylization. VI. Syntheses with hydrides of metal carbonyls. Justus Liebig Ann Chem 582:133–161
Beller M, Seayad J, Tillack A, Jiao H (2004) Catalytic Markovnikov and anti-Markovnikov functionalization of alkenes and alkynes: recent developments and trends. Angew Chem Int Ed 43:3368–3398
Eilbracht P, Bärfacker L, Buss C, Collmann C, Kitos-Rzychon BE, Kranemann CL, Rische T, Roggenbuck R, Schmidt A (1999) Tandem reaction sequences under hydroformylation conditions: new synthetic applications of transition metal catalysis. Chem Rev 99:3329–3366
Wittmann K, Wisniewski R, Mynott R, Leitner W, Kranemann CL, Rische T, Eilbracht P, Kluwer S, Ernsting JM, Elsevier CJ (2001) Supercritical carbon dioxide as solvent and temporary protecting group for rhodium-catalyzed hydroaminomethylation. Chem Eur J 7:4584–4589
da Rosa RG, de Campos RJD, Buffon R (1999) Effects of chelating diphosphines on the rhodium catalysed carbonylation of allylamines. J Mol Catal A Chem 137:297–301
Zhang Z, Ojima I (1993) Syntheses of nitrogen heterocycles by means of amine-directed carbonylation and hydrocarbonylation. J Organomet Chem 454:281–289
Chiou W-H, Schoenfelder A, Sun L, Mann A, Ojima I (2007) Rhodium-catalyzed cyclohydrocarbonylation approach to the syntheses of enantiopure homokainoids. J Org Chem 72:9418–9425
Vieira TO, Alper H (2007) Rhodium(I)-catalyzed hydroaminomethylation of 2-isopropenylanilines as a novel route to 1,2,3,4-tetrahydroquinolines. Chem Commun 2710–2711
Jesudason CD, Beavers LS, Cramer JW, Dill J, Finley DR, Lindsley CW, Stevens FC, Gadski RA, Oldham SW, Pickard RT, Siedem CS, Sindelar DK, Singh A, Watson BM, Hipskind PA (2006) Synthesis and SAR of novel histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:3415–3418
Lombardo LJ, Camuso A, Clark J, Fager K, Gullo-Brown J, Hunt JT, Inigo I, Kan D, Koplowitz B, Lee F, McGlinchey K, Qian L, Ricca C, Rovnyak G, Traeger S, Tokarski J, Williams DK, Wu LI, Zhao Y, Manne V, Bhide RS (2005) Design, synthesis, and structure– activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors. Bioorg Med Chem Lett 15:1895
Asolkar RN, Schröder D, Heckmann R, Lang S, Wagner-Döbler I, Laatsch H (2004) Helquinoline, a new tetrahydroquinoline antibiotic from Janibacter limosus Hel 1+. J Antibiot 57:17–23
Katritzky AR, Rachwal S, Rachwal B (1996) Recent progress in the synthesis of 1,2,3,4,-tetrahydroquinolines.Tetrahedron 52:15031–15070
Lu S-M, Wang Y-Q, Han X-W, Zhou Y-G (2006) Asymmetric hydrogenation of quinolines and isoquinolines activated by chloroformates. Angew Chem Int Ed 45:2260–2263
Rueping M, Theissmann T, Antonchick AP (2006) Metal-free Brønsted acid catalyzed transfer hydrogenation – new organocatalytic reduction of quinolines. Synlett 7:1071–1074
Lam KH, Xu L, Feng L, Fan Q-H, Lam FL, Lo W-H, Chan ASC (2005) Highly enantioselective iridium-catalyzed hydrogenation of quinoline derivatives using chiral phosphinite H8-BINAPO. Adv Synth Catal 347:1755–1758
Vieira TO, Alper H (2008) An efficient three-component one-pot approach to the synthesis of 2,3,4,5-tetrahydro-1H-2-benzazepines by means of rhodium-catalyzed hydroaminomethylation. Org Lett 10:485–487
Slugovc C, Burtscher D, Stelzer F, Mereiter K (2005) Thermally switchable olefin metathesis initiators bearing chelating carbenes: influence of the chelate’s ring size. Organometallics 24:2255–2258
Banwell MG, Kokas OJ, Willis AC (2007) Chemoenzymatic approaches to the montanine alkaloids: a total synthesis of (+)-brunsvigine. Org Lett 9:3503–3506
Mach UR, Hackling AE, Perachon S, Ferry S, Wermuth CG, Schwartz J-C, Sokoloff P, Stark H (2004) Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as potent and selective dopamine D3 receptor ligands. ChemBioChem 5:508–518
Johnson RE, Busacca CA (1992) Sterling drug, Inc. U.S. Patent 5,098,901; Fujisawa Pharmaceutical Co Ltd. US Appl 380,517
Okuro K, Alper H (2010) Ionic diamine rhodium complex catalyzed hydroaminomethylation of 2-allylanilines. Tetrahedron Lett 51:4959–4961
Nozaki K, Sakai N, Nanno T, Higashijima T, Mano S, Horiuchi T, Takaya H (1997) Highly enantioselective hydroformylation of olefins catalyzed by rhodium(I) complexes of new chiral phosphine−phosphite ligands. J Am Chem Soc 119:4413–4423
Airiau E, Girard N, Pizzetti M, Salvadori J, Taddei M, Mann A (2010) Hydroformylation of alkenylamines. Concise approaches toward piperidines, quinolizidines, and related alkaloids. J Org Chem 75:8670–8673
Caddick S, Fitzmaurice R (2009) Microwave enhanced synthesis. Tetrahedron 65:3325–3355
Jindal R, Bajaj S (2008) Recent applications of microwaves in synthesis of bioactive heterocyclic compounds. Curr Org Chem 12:836–849
Coquerel Y, Rodriguez J (2008) Microwave-assisted olefin metathesis. Eur J Org Chem 1125–1132
Solinas A, Taddei M (2007) Solid-supported reagents and catch-and-release techniques in organic synthesis. Synthesis 2409–2453
Petricci E, Mann A, Salvadori J, Taddei M (2007) Microwave assisted hydroaminomethylation of alkenes. Tetrahedron Lett 48:8501–8504
Petricci E, Mann A, Schoenfelder A, Rota A, Taddei M (2006) Microwaves make hydroformylation a rapid and easy process. Org Lett 8:3725–3727
Leadbeater NE, Torenius HM (2002) A study of the ionic liquid mediated microwave heating of organic solvents. J Org Chem 67:3145–3148
Chiou W-H, Mizutani N, Ojima I (2007) Highly efficient synthesis of Azabicyclo[x.y.0]alkane amino acids and congeners by means of Rh-catalyzed cyclohydrocarbonylation. J Org Chem 72:1871–1882
Cluzeau J, Lubell WD (2005) Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics. Biopolymers 80:98–150
Maison W (2005) Stereoselective synthesis of aza- and diazabicyclo[X.Y.0]alkane dipeptide mimetics. Synthesis 1031–1048
Hanessian S, Ronan B, Laoui A (1994) Design and synthesis of a prototype model antagonist of tachykinin NK-2 receptor. Bioorg Med Chem Lett 4:1397–1400
Genin MJ, Johnson RL (1992) Design, synthesis, and conformational analysis of a novel spiro-bicyclic system as a type II.beta.-turn peptidomimetic. J Am Chem Soc 114:8778–8783
Granberg D, Robinson JA (1994) Design and synthesis of a cis–gly–pro, type-VI turn, dipeptide mimetic and its use in fmoc-solid phase peptide synthesis. Tetrahedron Lett 35:861–864
Sato K, Nagai U (1986) Synthesis and antibiotic activity of a gramicidin S analogue containing bicyclic β-turn dipeptides. J Chem Soc Perkin Trans 1:1231–1234
Haubner R, Schmitt W, Hölzemann G, Goodman SL, Jonczyk A, Kessler H (1996) Cyclic RGD peptides containing β-turn mimetics. J Am Chem Soc 118:7881–7891
Chiou W-H, Lin G-H, Hsu C-C, Chaterpaul SJ, Ojima I (2009) Efficient syntheses of crispine A and harmicine by Rh-catalyzed cyclohydrocarbonylation. Org Lett 12:2659–2662
Ojima I, Tzamarioudaki M, Eguchi M (1995) New and efficient route to pipecolic acid derivatives by means of Rh-catalyzed intramolecular cyclohydrocarbonylation. J Org Chem 60:7078–7079
Ojima I, Zhang Z (1988) Novel amide-directed hydrocarbonylations and double carbonylation of N-allylamides. J Org Chem 53:4422–4425
Airiau E, Spangenber T, Girard N, Schoenfelder A, Salvadori J, Taddei M, Mann A (2008) General approach to aza-heterocycles by means of domino sequences driven by hydroformylation. Chem Eur J 14:10938–10948
Youn SW (2006) The Pictet–Spengler reaction: efficient carbon–carbon bond forming reaction in heterocyclic synthesis. Org Prep Proced Int 38:505–591
Larghi EL, Kaufman TS (2006) The Oxa–Pictet–Spengler cyclization: synthesis of isochromans and related pyran-type heterocycles. Synthesis 2:187–220
Airiau E, Chemin C, Girard N, Lonzi G, Mann A, Petricci E, Salvadori J, Taddei M (2010) Microwave-assisted domino hydroformylation/cyclization reactions: scope and limitations. Synthesis 17:2901–2914
Wakchaure PB, Easwar S, Argade NP (2009) Synthesis of the reported protoberberine gusanlung D. Synthesis 10:1667–1672
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Settambolo, R. (2013). Rhodium-Catalyzed Hydroformylation in Fused Azapolycycles Synthesis. In: Taddei, M., Mann, A. (eds) Hydroformylation for Organic Synthesis. Topics in Current Chemistry, vol 342. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2013_432
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DOI: https://doi.org/10.1007/128_2013_432
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