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Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines

  • Minghua Lu
  • Zongwei CaiEmail author
Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 331)

Abstract

Traditional Chinese medicines (TCMs) are attracting more and more attention because of their long historical clinical experience and reliable therapeutic efficacy for preventing and/or treating various human diseases. Many techniques and methods were developed for the analysis of TCMs to support new drug discovery and quality control. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), a soft ionization mass spectrometric technique, has been widely used in the analysis of a wide variety of large molecular compounds including proteins, peptides, and polymers since it was introduced in the late 1980s. In the present chapter, advances of MALDI-TOF MS in TCMs analysis have been reviewed. The review covers MALDI-TOF MS applications in the identification of new bioactive ingredients, analysis of alkaloids, determination of small molecular compounds with new matrices, proteomics analysis associated with TCMs, direct analysis of plant tissue, and other applications in TCMs.

Keywords

Chinese herbs MALDI-TOF MS Traditional Chinese medicines (TCMs) 

Abbreviations

2-DE

Two-dimensional gel electrophoresis

α-CHCA

α-Cyano-4-hydroxycinnamic acid

DHB

2,5-Dihydroxybenzoic acid

ESI

Electrospray ionization

HPLC

High performance liquid chromatography

IEC

Ion exchange chromatography

MALDI

Matrix-assisted laser desorption/ionization

MS

Mass spectrometry

TCMs

Traditional Chinese medicines

TLC

Thin-layer chromatography

TOF

Time-of-flight

Notes

Acknowledgements

We are thankful for the financial support from the National Nature Sciences Foundation of China (No. 20928005 and 21175025)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of ChemistryHong Kong Baptist UniversityHong Kong SARChina

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