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Synthetic and Biological Applications of Fluorous Reagents as Phase Tags

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Fluorous Chemistry

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 308))

Abstract

The search for new and better techniques for the purification of organic compounds has made the recent emergence of fluorous chemistry in the field of organic synthesis possible. Using fluorous reagents as phase tags allows for the access of different synthetic routes, and this has been translated into a time reduction and higher simplicity compared to standard, nonfluorous procedures. The synthesis in fluorous phase of target molecules can be pursued in a parallel or combinatorial manner in order to access chemical libraries with structural and/or stereochemical diversity. The preparation of radiolabeled molecules also benefits from the advantages of fluorous synthesis. Finally, biochemical tools such as microarrays or proteomic techniques are improved by means of fluorous-tagged compounds.

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Acknowledgments

We would like to thank MICINN (CTQ2010-19774) of Spain and Generalitat Valenciana (PROMETEO/2010/061) for their financial support. J.L.A. expresses his gratitude to MICINN for a Ramón y Cajal contract and S. C. expresses her thanks to MICINN for a Juan de la Cierva contract.

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Authors and Affiliations

  1. Departamento de Química Orgánica, Universidad de Valencia, 46100, Burjassot, Spain

    Santos Fustero

  2. Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, 46012, Valencia, Spain

    Santos Fustero, José Luis Aceña & Silvia Catalán

Authors
  1. Santos Fustero
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  2. José Luis Aceña
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  3. Silvia Catalán
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Corresponding author

Correspondence to Santos Fustero .

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Editors and Affiliations

  1. , Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, China, People's Republic

    István T. Horváth

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Fustero, S., Aceña, J.L., Catalán, S. (2011). Synthetic and Biological Applications of Fluorous Reagents as Phase Tags. In: Horváth, I. (eds) Fluorous Chemistry. Topics in Current Chemistry, vol 308. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_263

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