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Fluorous Organocatalysis

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Fluorous Chemistry

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 308))

Abstract

Organocatalysis is a new and fast growing research area, especially for asymmetric synthesis. Compared to metal catalysis and biocatalysis, organocatalysis has a number of unique features such metal-free, mild reaction conditions, novel mode of activations, and good structural amenability. Fluorous organocatalysis provides an efficient way for catalyst recovery. In addition to phase tag separation, fluorous chain can also be used to modify the reactivity and selectivity in the design of new catalysts.

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Abbreviations

Boc:

tert-Butyloxycarbonyl

BTF:

Benzotrifluoride

CBS:

Corey-Bakshi-Shibata

CBZ:

Carboxybenzyl

DABCO:

1,4-Diazabicyclo[2.2.2]octane

DBU:

Diazabicyclo[5.4.0]undec-7-ene

DIBAL:

Diisobutylaluminum hydride

DMAP:

4-N,N-Dimethylaminopyridine

F-LLE:

Fluorous liquid–liquid extraction

F-SPE:

Fluorous solid-phase extraction

HFIP:

Hexafluoroisopropanol

NCS:

N-Chlorosuccinimide

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Acknowledgments

University of Massachusetts Boston, Joseph P. Healey, and Proposal Development Program grants for supporting the green chemistry and fluorous organocatalysis projects are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA, 02125, USA

    Wei Zhang

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  1. Wei Zhang
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Correspondence to Wei Zhang .

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Editors and Affiliations

  1. , Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, China, People's Republic

    István T. Horváth

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© 2011 Springer-Verlag Berlin Heidelberg

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Zhang, W. (2011). Fluorous Organocatalysis. In: Horváth, I. (eds) Fluorous Chemistry. Topics in Current Chemistry, vol 308. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_257

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