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Pyrethroids pp 113-135 | Cite as

Biotransformation and Enzymatic Reactions of Synthetic Pyrethroids in Mammals

Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 314)

Abstract

Synthetic pyrethroids, a major insecticide group, are used worldwide for controlling indoor and agricultural pests. Extensive mammalian metabolism studies have been carried out since the late 1960s, and major metabolic reactions have been found to be oxidation of the acid or alcohol moiety, ester cleavage, and conjugation reactions. In addition, various conjugation reactions occur in mammals, forming hydrophilic and lipophilic conjugates. Pyrethroids are generally rapidly metabolized in mammals and completely excreted from the body in a short period. Human and laboratory animals share similar metabolic reactions for pyrethroids. Oxidation reactions in humans are mediated by several CYP isoforms. On the other hand, ester bonds of pyrethroids are hydrolyzed mainly by carboxylesterase(s).

Keywords

Carboxylesterase CYP Ester hydrolysis Metabolism Oxidation Pyrethroid 

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Copyright information

© Springer-Verlag Berlin-Heidelberg 2011

Authors and Affiliations

  1. 1.Environmental Health Science LaboratorySumitomo Chemical Co., LtdOsakaJapan

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