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The Multiple Carbohydrate Binding Specificities of Helicobacter pylori

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Glycoscience and Microbial Adhesion

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 288))

Abstract

Persistent colonization of the human stomach by Helicobacter pylori is a risk factor for the development of peptic ulcer disease and gastric cancer. Adhesion of microbes to the target tissue is an important determinant for successful initiation, establishment and maintenance of infection, and a variety of different candidate carbohydrate receptors for H. pylori have been identified. Here the different the binding specifities, and their potential role in adhesion to human gastric epithelium are described. Finally, recent findings on the roles of sialic acid binding SabA adhesin in interactions with human neutrophils and erythrocytes are discussed.

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Abbreviations

BabA:

blood group antigen binding adhesin

HpaA:

H. pylori adhesin A

HP-NAP:

neutrophil-activating protein of Helicobacter pylori

SabA:

sialic acid binding adhesin.The glycosphingolipid nomenclature follows the recommendations by the IUPAC-IUB Commission on Biochemical Nomenclature (CBN for Lipids: Eur J Biochem 257:293, 1998).

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Authors and Affiliations

  1. Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Göteborg University, P.O. Box 440, 405 30 Göteborg, Sweden

    Susann Teneberg

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  1. Susann Teneberg
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Correspondence to Susann Teneberg .

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Editors and Affiliations

  1. Inst. Organische Chemie, Universität Kiel, Otto-Hahn-Platz 3, Kiel, 24118, Germany

    Thisbe K. Lindhorst

  2. Arrhenius Laboratory, Stockholm University, Stockholm, 106 91, Sweden

    Stefan Oscarson

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Teneberg, S. (2008). The Multiple Carbohydrate Binding Specificities of Helicobacter pylori. In: Lindhorst, T., Oscarson, S. (eds) Glycoscience and Microbial Adhesion. Topics in Current Chemistry, vol 288. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2008_14

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