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Carbohydrate Receptors of Bacterial Adhesins: Implications and Reflections

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Glycoscience and Microbial Adhesion

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 288))

Abstract

Bacteria entering a host depend on adhesins to achieve colonization. Adhesins are bacterial surface structures mediating binding to host surficial areas. Most adhesins are composed of one or several proteins. Usually a single bacterial strain is able to express various adhesins. The adhesion type expressed may influence host-, tissue or even cell tropism of Gram-negative and of Gram-positive bacteria. The binding of fimbrial as well as of afimbrial adhesins of Gram-negative bacteria to host carbohydrate structures (=receptors) has been elucidated in great detail. In contrast, in Gram-positives, most well studied adhesins bind to proteinaceous partners. Nevertheless, for both bacterial groups the binding of bacterial adhesins to eukaryotic carbohydrate receptors is essential for establishing colonization or infection. The characterization of this interaction down to the submolecular level provides the basis for strategies to interfere with this early step of infection which should lead to the prevention of subsequent disease. However, this goal will not be achieved easily because bacterial adherence is not a monocausal event but rather mediated by a variety of adhesins.

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Authors and Affiliations

  1. Institut für Molekulare Infektionsbiologie, Röntgenring 11, 97070, Würzburg

    K. Ohlsen, T. A. Oelschlaeger, J. Hacker & A. S. Khan

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  1. K. Ohlsen
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  2. T. A. Oelschlaeger
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  3. J. Hacker
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  4. A. S. Khan
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Editors and Affiliations

  1. Inst. Organische Chemie, Universität Kiel, Otto-Hahn-Platz 3, Kiel, 24118, Germany

    Thisbe K. Lindhorst

  2. Arrhenius Laboratory, Stockholm University, Stockholm, 106 91, Sweden

    Stefan Oscarson

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Ohlsen, K., Oelschlaeger, T.A., Hacker, J., Khan, A.S. (2008). Carbohydrate Receptors of Bacterial Adhesins: Implications and Reflections. In: Lindhorst, T., Oscarson, S. (eds) Glycoscience and Microbial Adhesion. Topics in Current Chemistry, vol 288. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2008_10

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