Skip to main content
SpringerLink
Log in

Modulation of the Bioactive Conformation of Transforming Growth Factor β: Possible Implications of Cation Binding for Biological Function

  • Chapter
  • First Online:
Bioactive Conformation II

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 273))

Abstract

In any organism, very precisely adjusted interaction and exchange of information between cellsis continuously required. These cooperative interactions involve numerous cytokines, acting throughcorresponding sets of cell-surface receptors. The transforming growth factor β (TGF-β)superfamily includes a variety of structurally related multifunctional cytokines that play criticalroles in maintaining cellular homeostasis and controlling cell fate. Response of a cell to a specificsignal it receives should depend upon the current state of the environment, including concentrationsof biologically relevant ions. One of the most biologically active ions, calcium, acts upon a specificcalcium signaling system that operates over a wide temporal range and regulates many cellularprocesses in continuous “cross-talk” with the TGF-β signaling system. In additionto that, the structural and dynamical properties of TGF-β molecules, along with detected directinteraction of them with the biologically relevant cations suggest another level of fine regulationof TGF-β activity. The fact that both mono- and divalent cations bind in the same low-affinitysites implies that some competition of cations for interaction with TGF-β can also occur in vivo,contributing to the diversity of TGF-β biological functions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Massagué J (1998) Annu Rev Biochem 67:753

    Article  Google Scholar 

  2. Massagué J, Chen Y-G (2000) Genes Dev 14:627

    Google Scholar 

  3. Massagué J, Blain SW, Roger SL (2000) Cell 103:295

    Article  Google Scholar 

  4. Blobe GC, Schiemann WP, Lodish HF (2000) N Engl J Med 342:1350

    Article  CAS  Google Scholar 

  5. Letterio JJ, Roberts AB (1998) Annu Rev Immunol 16:137

    Article  CAS  Google Scholar 

  6. Miyazono K, Kusanagi K, Inoue H (2001) J Cell Physiol 103:295

    Google Scholar 

  7. Lijnen PJ, Petrov VV, Fagard RH (2003) Am J Hypertens 16:605

    Article  Google Scholar 

  8. Reeves WB, Andreoli TE (2000) Proc Natl Acad Sci USA 97:7667

    Article  CAS  Google Scholar 

  9. Sanders PW (2004) Hypertension 43:142

    Article  CAS  Google Scholar 

  10. Sharma K, McGowan TA (2000) Cytokine Growth Factor Rev 11:115

    Article  CAS  Google Scholar 

  11. Katagiri T, Takahashi N (2002) Oral Dis 8:147

    Article  CAS  Google Scholar 

  12. Shi Y, Massagué J (2003) Cell 113:685

    Article  CAS  Google Scholar 

  13. Piek E, Heldin C-H, ten Dijke P (1999) FASEB J 13:2105

    CAS  Google Scholar 

  14. Bocharov EV, Korzhnev DM, Blommers MJJ, Arvinte T, Orekhov VY, Billeter M, Arseniev AS (2002) J Biol Chem 277:46273

    Article  CAS  Google Scholar 

  15. Greenwald J, Vega ME, Allendorph GP, Fischer WH, Vale W, Choe S (2004) Mol Cell 15:485

    Article  CAS  Google Scholar 

  16. Hart PJ, Deep S, Taylor AB, Shu Z, Hinck CS, Hinck AP (2002) Nat Struct Biol 9:203

    CAS  Google Scholar 

  17. Thompson TB, Woodruff TK, Jardetzky TS (2003) EMBO J 22:1555

    Article  CAS  Google Scholar 

  18. Souchelnytskyi S, Moustakas A, Heldin C-H (2002) Trends Cell Biol 12:304

    Article  CAS  Google Scholar 

  19. Derynck R, Feng X-H (1997) Biochim Biophys Acta 1333:105

    Google Scholar 

  20. Blobe GC, Schiemann WP, Pepin M-C, Beauchemin M, Moustakas A, Lodish HF, O’Connor-McCourt MD (2001) J Biol Chem 276:24627

    Article  CAS  Google Scholar 

  21. Qin BY, Lam SS, Correia JJ, Lin K (2002) Genes Dev 16:1950

    Article  CAS  Google Scholar 

  22. Campbell AK (1983) Intracellular calcium: Its universal role as regulator. John Wiley & Sons Ltd., Norwich

    Google Scholar 

  23. Brown EM, MacLeod RJ (2001) Physiol Rev 81:239

    CAS  Google Scholar 

  24. Raya Á, Kawakaml Y, Rodriguez-Esteban C, Ibanes M, Rasskin-Gutman D, Rodriguez-León J, Büscher D, Feijó JA, Belmonte JCI (2004) Nature 427:121

    Article  CAS  Google Scholar 

  25. Berridge MJ, Bootman MD, Roderick HL (2003) Nat Rev Mol Cell Biol 4:517

    Article  CAS  Google Scholar 

  26. Webb SH, Moreau M, Leclerc C, Miller AL (2005) Cell Calcium 37:375

    Article  CAS  Google Scholar 

  27. Ishiyama N, Shibata H, Kanzaki M, Shiozaki S, Miyazaki J-I, Kobayashi I, Kojima I (1996) Mol Cell Endocrinol 117:1

    Article  CAS  Google Scholar 

  28. McGowan TA, Madesh M, Zhu Y, Wang L, Russo M, Deelman L, Henning R, Joseph S, Hajnóczky G, Sharma K (2002) Am J Physiol 282:F910

    CAS  Google Scholar 

  29. Sharma K, McGowan TA, Wang L, Madesh M, Kaspar V, Szalai G, Thomas AP, Hajnóczky G (2000) Am J Physiol 278:F1022

    CAS  Google Scholar 

  30. Chen C-H, Seguin-Devaux C, Burke NA, Oriss TB, Watkins SC, Clipstone N, Ray A (2003) J Exp Med 197:1689

    Article  CAS  Google Scholar 

  31. Martineau I, Lacoste E, Gagnon G (2004) Biomaterials 25:4489

    Article  CAS  Google Scholar 

  32. Nakade O, Takahashi K, Takuma T, Aoki T, Kaku T (2001) J Bone Miner Metab 19:13

    Article  CAS  Google Scholar 

  33. Wang D, Canaff L, Davidson D, Carluka A, Liu H, Hendy GN, Henderson JE (2001) J Biol Chem 276:33995

    Article  CAS  Google Scholar 

  34. Sakaguchi M, Sonegawa H, Nukui T, Sakaguchi Y, Miyazaki M, Namba M, Huh N (2005) Proc Natl Acad Sci USA 102:13921

    Article  CAS  Google Scholar 

  35. Muldoon LL, Rodland KD, Magun BE (1988) J Biol Chem 263:18834

    CAS  Google Scholar 

  36. Gooch JL, Gorin Y, Zhang B-X, Abboud HE (2004) J Biol Chem 279:15561

    Article  CAS  Google Scholar 

  37. Chuang C-C, Tan S-K, Tai L-K, Hsin J-P, Wang F-F (1998) Mol Pharmacol 53:1054

    CAS  Google Scholar 

  38. Purroy J, Spurr NK (2002) Hum Mol Genet 11:2377

    Article  CAS  Google Scholar 

  39. Mostov K, Werb Z (1997) Science 276:219

    Article  CAS  Google Scholar 

  40. Gombotz WR, Pankey SC, Bouchard LS, Phan DH, Puolakkainen PA (1994) J Appl Biomater 5:141

    Article  CAS  Google Scholar 

  41. Blom EJ, Klein-Nulend J, Kurashina K, van Waas MA, Burger EH (2000) J Biomed Mater Res 50:67

    Article  CAS  Google Scholar 

  42. Kamakura S, Sasano Y, Nakajo S, Shimizo T, Suzuki O, Katou F, Kagayama M, Motegi K (2001) J Biomed Mater Res 57:175

    Article  CAS  Google Scholar 

  43. Arvinte T, Schote UT, Sigg J (2000) Patent WO/2000/054797

    Google Scholar 

  44. Quinn SJ, Kifor O, Trivedi S, Diaz R, Vassilev P, Brown E (1998) J Biol Chem 273:19579

    Article  CAS  Google Scholar 

  45. Ying W-Z, Sanders PW (2002) Hypertension 39:239

    Article  CAS  Google Scholar 

  46. Murphy-Ullrich JE, Poczatek M (2000) Cytokine Growth Factor Rev 11:59

    Article  CAS  Google Scholar 

  47. Mangasser-Stephan K, Gressner AM (1999) Cell Tissue Res 297:363

    Article  CAS  Google Scholar 

  48. Ten Dijke P, Hill CS (2004) Trends Biochem Sci 29:265

    Article  CAS  Google Scholar 

  49. Sebald W, Mueller TD (2003) Trends Biochem Sci 28:518

    Article  CAS  Google Scholar 

  50. Derynck R, Zhang YE (2003) Nature 425:577

    Article  CAS  Google Scholar 

  51. Mittl PRE, Priestle JP, Cox DA, McMaster G, Cerletti N, Grütter MG (1996) Protein Sci 5:1261

    Article  CAS  Google Scholar 

  52. Kirsch T, Sebald W, Dreyer MK (2000) Nat Struct Biol 7:492

    Article  CAS  Google Scholar 

  53. Huang SS, Zhou M, Johnson FE, Shieh H-S, Huang JS (1999) J Biol Chem 274:27754

    Article  CAS  Google Scholar 

  54. Keller S, Nickel J, Zhang J-L, Sebald W, Mueller TD (2004) Nat Struct Mol Biol 11:481

    Article  CAS  Google Scholar 

  55. Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S (2003) Mol Cell 11:605

    Article  CAS  Google Scholar 

  56. Hinck AP, Archer SJ, Qian SW, Roberts AB, Sporn MB, Weatherbee JA, Tsang ML-S, Lucas R, Zhang B-L, Wenker J, Torchia DA (1996) Biochemistry 35:8517

    Article  CAS  Google Scholar 

  57. Pellaud J, Schote U, Arvinte T, Seelig J (1999) J Biol Chem 274:7699

    Article  CAS  Google Scholar 

  58. Keah HH, Hearn TW (2005) J Mol Recognit 18:385

    Article  CAS  Google Scholar 

  59. De Creszenso G, Grothe S, Zwaagstra J, Tsang M, O’Connor-McCourt MD (2001) J Biol Chem 276:29632

    Article  Google Scholar 

  60. De Creszenso G, Pham LP, Durocher Y, O’Connor-McCourt MD (2003) J Mol Biol 328:1173

    Article  Google Scholar 

  61. De Creszenso G, Pham LP, Durocher Y, Chao H, O’Connor-McCourt MD (2004) J Biol Chem 279:26013

    Article  Google Scholar 

  62. Moriki T, Maruyama H, Maruyama IN (2001) J Mol Biol 311:1011

    Article  CAS  Google Scholar 

  63. Chi J-I, Yokota H, Kim S-H (1997) FEBS Lett 414:327

    Article  CAS  Google Scholar 

  64. Bell CA, Tynan JA, Kristen CH, Meyer AN, Robertson SC, Donoghue DJ (2000) Mol Biol Cell 11:3589

    CAS  Google Scholar 

  65. Fleishman SJ, Schlessinger J, Ben-Tal N (2002) Proc Natl Acad Sci USA 99:15937

    Article  CAS  Google Scholar 

  66. Zhu H-J, Sizeland AM (1999) J Biol Chem 274:11773

    Article  CAS  Google Scholar 

  67. Zhu H-J, Sizeland AM (1999) J Biol Chem 274:29220

    Article  CAS  Google Scholar 

  68. Bocharov EV, Blommers MJJ, Kuhla J, Arvinte T, Bürgi R, Arseniev AS (2000) J Biomol NMR 16:179

    Article  CAS  Google Scholar 

  69. Jordan JD, Landau EM, Iyengar R (2000) Cell 103:193

    Article  CAS  Google Scholar 

  70. Korolev N, Lyubartsev AP, Rupprecht A, Nordenskiöld L (1999) Biophys J 77:2736

    Article  CAS  Google Scholar 

  71. Di Paolo ML, Scarpa M, Corazza A, Stevanato R, Rigo A (2002) Biophys J 83:2231

    Article  Google Scholar 

  72. Erbas H, Lennard TW, Lai LC (1999) Anticancer Res 19:3077

    CAS  Google Scholar 

  73. Hallab NJ, Vermes C, Messina C, Roebuck KA, Glant TT, Jacobs JJ (2002) J Biomed Mater Res 60:420

    Article  CAS  Google Scholar 

  74. Eisman JA (1999) Endocrine Rev 20:788

    Article  CAS  Google Scholar 

  75. Janssens K, ten Dijke P, Janssens S, Hul WV (2005) Endocrine Rev 26:743

    Article  CAS  Google Scholar 

  76. Clines GA, Guise TA (2005) Endocrine-Related Cancer 12:549

    Article  CAS  Google Scholar 

  77. Jaunberzins A, Gutmann JL, Witherspoon DE, Harper RP (2000) J Endodont 26:494

    Article  CAS  Google Scholar 

  78. Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR, Brown EM (2000) Endocrinology 141:4357

    Article  CAS  Google Scholar 

  79. Efremov RG, Vergoten G (1995) Phys Chem 99:10658

    Article  CAS  Google Scholar 

  80. Koradi R, Billeter M, Wüthrich K (1996) J Mol Graphics 14:51

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, ul. Miklukho-Maklaya, 16/10, 117997, Moscow, Russia

    Eduard V. Bocharov & Alexander S. Arseniev

  2. Frumkin Institute of Electrochemistry, Russian Academy of Science, 117071, Moscow, Russia

    Konstantin V. Pavlov

  3. Novartis Pharma AG, 4002, Basel, Switzerland

    Marcel J. J. Blommers

  4. School of Pharmacy, Department of Pharmaceutics and Biopharmaceutics, University of Geneva, 1211, Geneva, Switzerland

    Tudor Arvinte

Authors
  1. Eduard V. Bocharov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Konstantin V. Pavlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marcel J. J. Blommers
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tudor Arvinte
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alexander S. Arseniev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eduard V. Bocharov .

Editor information

Thomas Peters

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bocharov, E.V., Pavlov, K.V., Blommers, M.J.J., Arvinte, T., Arseniev, A.S. (2008). Modulation of the Bioactive Conformation of Transforming Growth Factor β: Possible Implications of Cation Binding for Biological Function. In: Peters, T. (eds) Bioactive Conformation II. Topics in Current Chemistry, vol 273. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2007_17

Download citation

Publish with us

Policies and ethics

Search

Navigation