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Continuous Asymmetric Hydrogenation

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In situ NMR Methods in Catalysis

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 276))

Abstract

Asymmetric hydrogenation with homogeneous soluble catalysts is a key technology for the production of enantiomerically enriched fine chemicals. Hydrogen supply via dense membranes in combination with continuous membrane filtration of soluble macromolecular catalysts allows for continuous hydrogenation. A optimised reactor with minimized volume was realized and used for continuous enzymatic and homogeneous catalysis. The vital importance of catalyst stability for continuous application is discussed. Furthermore, activation kinetics of the Pyrphos catalyst was investigated and found to be dependent on the presence of substrate.

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Acknowledgments

We thank Andreas Franz, Daniela H. Müller and Christian R. Reimers (all of Forschungszentrum Jülich) for skilful technical support. The research was made possible by financial support from the German Federal Ministry of Education and Research (BMBF) and Degussa AG.

Author information

Authors and Affiliations

  1. RWTH Aachen University, Institut für Technische und Makromolekulare Chemie, Worringerweg 1, 52074, Aachen, Germany

    Lasse Greiner

  2. Bu-PLS-P & T-PD, Bayer Material Science, 51368, Uerdingen, Germany

    Stephan Laue

  3. Degussa AG, Rodenbacher Chaussee 4, 63457, Hanau-Wolfgang, Germany

    Jens Wöltinger

  4. Institute of Technical Biocatalysis, Hamburg University of Technology TUHH, Dennickestr. 15, 21073, Hamburg, Germany

    Andreas Liese

Authors
  1. Lasse Greiner
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  2. Stephan Laue
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  3. Jens Wöltinger
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  4. Andreas Liese
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Corresponding author

Correspondence to Andreas Liese .

Editor information

Joachim Bargon Lars T. Kuhn

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© 2006 Springer-Verlag Berlin Heidelberg

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Greiner, L., Laue, S., Wöltinger, J., Liese, A. (2006). Continuous Asymmetric Hydrogenation. In: Bargon, J., Kuhn, L.T. (eds) In situ NMR Methods in Catalysis. Topics in Current Chemistry, vol 276. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2006_096

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