Skip to main content
SpringerLink
Log in

Synthetic Glycopeptide-Based Vaccines

  • Chapter
  • First Online:
Glycopeptides and Glycoproteins

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 267))

Abstract

This review provides an overview of our explorations into oligosaccharide and glycoconjugate construction for the creation and evaluation of glycopeptide-based vaccines. The basis for these investigations is the known tendency of both cancer cells and viruses to express selective carbohydrate motifs in the form of glycoproteins or glycolipids. Utilization of these carbohydrates in a glycopeptide-based vaccine could potentially trigger immune recognition, generating a protective response against the disease. However, obtaining large quantities of such compounds from natural sources is extremely difficult. Over the past two decades, our lab has been engaged in the total synthesis of complex oligosaccharides and glycoconjugates. With this knowledge and experience, we have begun to evaluate, in many cases at the clinical level, whether the human immune system is capable of mounting a response against such fully synthetic carbohydrate antigens in a focused and useful way. Toward this goal, we have merged the powers of both chemistry and immunology to provide insight into this problem. The synthesis and evaluation of potential vaccines for both cancer and HIV will be described.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

Ac:

acetyl

Bn:

benzyl

Boc:

tert-butoxycarbonyl

Bz:

benzoyl

DMDO:

3,3-dimethyldioxirane

DTBP:

di-tert-butylpyridine

ELISA:

enzyme-linked immunosorbent assay

Fmoc:

fluoren-9-ylmethylcarbonyl

ivDde:

4,4-dimethyl-2,6-dioxocyclohex-1-ylidine-3-methylbutyl

KLH:

keyhole limpet hemocyanin

MBS:

m-maleimidobenzoyl-N-hydroxysuccinimide ester

MCA:

monochloroacetyl

MesNa:

sodium 2-mercaptoethanesulfonate

MMCCH:

4-(4-N-maleimidomethyl)cyclohexane-1-carboxylic acid hydrazide

NCL:

native chemical ligation

Pam3Cys:

tripalmitoyl-S-glycerylcysteinylserine

Phth:

phthaloyl

py:

pyridine

SCLC:

small cell lung cancer

SPR:

surface plasmon resonance

TBAF:

tetrabutylammonium fluoride

TBS:

tert-butyldimethylsilyl

TFA:

trifluoroacetic acid

TIPS:

triisopropylsilyl

References

  1. Haurowitz F (1979) Trends Biochem Sci 4:N268

    Article  CAS  Google Scholar 

  2. Silverstein AM (1989) In: A History of Immunology, chap. 1 and 12. Academic Press, San Diego

    Google Scholar 

  3. Rosen FS, Mackay I (2001) New Eng J Med 345:1343

    Article  CAS  Google Scholar 

  4. Livingston PO (1992) Curr Opin Immunol 4:624

    Article  CAS  Google Scholar 

  5. Lanzavecchia A (1993) Science 260:937

    Article  CAS  Google Scholar 

  6. Pardoll DM (1993) Curr Opin Immunol 5:719

    Article  CAS  Google Scholar 

  7. Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC (1993) Proc Natl Acad Sci USA 90:3539

    Article  CAS  Google Scholar 

  8. Tao MH, Levy R (1993) Nature 362:755

    Article  CAS  Google Scholar 

  9. Boon T (1993) Int J Cancer 54:177

    Article  CAS  Google Scholar 

  10. Danishefsky SJ, Allen JR (2000) Angew Chem Int Ed Engl 39:836

    Article  CAS  Google Scholar 

  11. Mandal M, Dudkin VY, Geng X, Danishefsky SJ (2004) Angew Chem Int Ed Engl 43:2557

    Article  CAS  Google Scholar 

  12. Geng X, Dudkin VY, Mandal M, Danishefsky SJ (2004) Angew Chem Int Ed Engl 43:2562

    Article  CAS  Google Scholar 

  13. Paulsen H (1982) Angew Chem Int Ed Engl 21:155

    Article  Google Scholar 

  14. Schmidt RR (1991) In: Trost BM, Flemming I (eds) Comprehensive organic synthesis: selectivity, strategy and efficiency in modern organic chemistry, vol 6. Pergamon Press, Inc. p 33

    Google Scholar 

  15. Toshima K, Tatsuta K (1993) Chem Rev 93:1503

    Article  CAS  Google Scholar 

  16. Danishefsky SJ, Bilodeau MT (1996) Angew Chem Int Ed Engl 35:1380

    Article  CAS  Google Scholar 

  17. Boons GJ (1996) Contemp Org Synth 3:173

    Article  CAS  Google Scholar 

  18. Boons GJ (1996) Tetrahedron 52:1095

    Article  CAS  Google Scholar 

  19. Davis BG (2000) J Chem Soc, Perkin Trans 1:2137

    Article  Google Scholar 

  20. Seeberger PH (2002) J Carbohydr Chem 21:613

    Article  CAS  Google Scholar 

  21. Varki A (1999) In: Varki A, Cummings R, Esco J, Freeze H, Hart G, Marth J (eds) Essentials of Glycobiology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, p. 537

    Google Scholar 

  22. Livingston PO, Zhang SL, Lloyd KO (1997) Cancer Immunol Immunother 45:1

    Article  CAS  Google Scholar 

  23. Cobb Ba, Kasper DL (2005) Eur J Immunol 35:352

    Article  CAS  Google Scholar 

  24. Beuvery EC, Vanrossum F, Nagel J (1982) Infect Immun 37:15

    CAS  Google Scholar 

  25. Barrett DJ, Ammann AJ, Stenmark S, Wara DW (1980) Infect Immun 27:411

    CAS  Google Scholar 

  26. Kasper DL, Paoletti LC, Wessels MR, Guttormsen HK, Carey VJ, Jennings HJ, Baker CJ (1996) J Clin Invest 98:2308

    Article  CAS  Google Scholar 

  27. Keding SJ, Danishefsky SJ (2003) In: Wong CH (ed) Carbohydrate-Based Drug Discovery, vol 1. Wiley, Weinheim, Germany, p 381

    Google Scholar 

  28. Stroud MR, Levery SB, Nudelman ED, Salyan ME, Towell JA, Roberts CE, Watanabe M, Hakomori S (1991) J Biol Chem 266:8439

    CAS  Google Scholar 

  29. Stroud MR, Levery SB, Martensson S, Salyan ME, Clausen H, Hakomori S (1994) Biochemistry 33:10672

    Article  CAS  Google Scholar 

  30. Yuen CT, Bezouska K, Obrien J, Stoll M, Lemoine R, Lubineau A, Kiso M, Hasegawa A, Bockovich NJ, Nicolaou KC, Feizi T (1994) J Biol Chem 269:1595

    CAS  Google Scholar 

  31. Ragupathi G, Koide F, Sathyan N, Kagan E, Spassova M, Bornmann W, Gregor P, Reis CA, Clausen H, Danishefsky SJ, Livingston PO (2003) Cancer Immunol Immunother 52:608

    Article  CAS  Google Scholar 

  32. Nilsson O, Mansson J-E, Brezicka T, Holmgren J, Lindholm L, Sorensen S, Yngvason F, Szennerholm L (1984) Glycoconjugate J 1:43

    Article  CAS  Google Scholar 

  33. Nilsson O, Brezicka FT, Holmgren J, Sorenson S, Svennerholm L, Yngvason F, Lindholm L (1986) Cancer Res 46:1403

    CAS  Google Scholar 

  34. Brezicka FT, Olling S, Nilsson O, Bergh J, Holmgren J, Sorenson S, Yngvason F, Lindholm L (1989) Cancer Res 49:1300

    CAS  Google Scholar 

  35. Vangsted AJ, Clausen H, Kjeldsen TB, White T, Sweeney B, Hakomori S, Drivsholm L, Zeuthen J (1991) Cancer Res 51:2879

    CAS  Google Scholar 

  36. Brezicka T, Bergman B, Olling S, Fredman P (2000) Lung Cancer 28:29

    Article  CAS  Google Scholar 

  37. Zhang SL, CordonCardo C, Zhang HS, Reuter VE, Adluri S, Hamilton WB, Lloyd KO, Livingston PO (1997) Int J Cancer 73:42

    Article  CAS  Google Scholar 

  38. Markl J, Lieb B, Gebauer W, Altenhein B, Meissner U, Harris JR (2001) J Cancer Res Clin Oncol 127 Suppl 2:R3

    Google Scholar 

  39. Dickler MN, Ragupathi G, Liu NX, Musselli C, Martino DJ, Miller VA, Kris MG, Brezicka FT, Livingston PO, Grant SC (1999) Clin Cancer Res 5:2773

    CAS  Google Scholar 

  40. Allen JR, Danishefsky SJ (1999) J Am Chem Soc 121:10875

    Article  CAS  Google Scholar 

  41. Krug LM, Ragupathi G, Hood C, Kris MG, Miller VA, Allen JR, Keding SJ, Danishefsky SJ, Gomez J, Tyson L, Pizzo B, Baez V, Livingston PO (2004) Clin Cancer Res 10:6094

    Article  CAS  Google Scholar 

  42. Hellström I, Garrigues HJ, Garrigues U, Hellström KE (1990) Cancer Res 50:2183

    Google Scholar 

  43. Federici MF, Kudryashov V, Saigo PE, Finstad CL, Lloyd KO (1999) Int J Cancer 81:193

    Article  CAS  Google Scholar 

  44. Zhang SL, Zhang HS, CordonCardo C, Reuter VE, Singhal AK, Lloyd KO, Livingston PO (1997) Int J Cancer 73:50

    Article  CAS  Google Scholar 

  45. Behar V, Danishefsky SJ (1994) Angew Chem Int Ed Engl 33:1468

    Article  Google Scholar 

  46. Danishefsky SJ, Behar V, Randolph JT, Lloyd KO (1995) J Am Chem Soc 117:5701

    Article  CAS  Google Scholar 

  47. Kudryashov V, Kim HM, Ragupathi G, Danishefsky SJ, Livingston PO, Lloyd KO (1998) Cancer Immunol Immunother 45:281

    Article  CAS  Google Scholar 

  48. Sabbatini P, Kudryashov V, Ragupathi G, Danishefsky SJ, Livingston PO, Bornmann W, Spassova M, Zatorski A, Spriggs D, Aghajanian C, Soignet S, Peyton M, O'Flaherty C, Curtin J, Lloyd KO (2000) Int J Cancer 87:79

    Article  CAS  Google Scholar 

  49. Nudelman E, Levery SB, Kaizu T, Hakomori S (1986) J Biol Chem 261:11247

    CAS  Google Scholar 

  50. Deshpande PP, Danishefsky SJ (1997) Nature 387:164

    Article  CAS  Google Scholar 

  51. Deshpande PP, Kim HM, Zatorski A, Park TK, Ragupathi G, Livingston PO, Live D, Danishefsky SJ (1998) J Am Chem Soc 120:1600

    Article  CAS  Google Scholar 

  52. Spassova MK, Bornmann WG, Ragupathi G, Sukenick G, Livingston PO, Danishefsky SJ (2005) J Org Chem 70:3383

    Article  CAS  Google Scholar 

  53. Kaizu T, Levery SB, Nudelman E, Stenkamp RE, Hakomori S (1986) J Biol Chem 261:11254

    CAS  Google Scholar 

  54. Kim YS, Yuan M, Itzkowitz SH, Sun QB, Kaizu T, Palekar A, Trump BF, Hakomori S (1986) Cancer Res 46:5985

    CAS  Google Scholar 

  55. Ragupathi G, Deshpande PP, Coltart DM, Kim HM, Williams LJ, Danishefsky SJ, Livingston PO (2002) Int J Cancer 99:207

    Article  CAS  Google Scholar 

  56. Kabat EA (1976) In: Structural Concepts in Immunology and Immunochemistry. Holt, Rinehart and Winston, New York, p 119

    Google Scholar 

  57. Kannagi R, Levery SB, Ishigami F, Hakomori S, Shevinsky LH, Knowles BB, Solter D (1983) J Biol Chem 258:8934

    CAS  Google Scholar 

  58. Bremer EG, Levery SB, Sonnino S, Ghidoni R, Canevari S, Kannagi R, Hakomori S (1984) J Biol Chem 259:14773

    CAS  Google Scholar 

  59. Menard S, Tagliabue E, Canevari S, Fossati G, Colnaghi MI (1983) Cancer Res 43:1295

    CAS  Google Scholar 

  60. Livingston PO (1995) Semin Cancer Biol 6:357

    Article  CAS  Google Scholar 

  61. Zhang SL, Zhang HS, Reuter VE, Slovin SF, Scher HI, Livingston PO (1998) Clin Cancer Res 4:295

    CAS  Google Scholar 

  62. Bilodeau MT, Park TK, Hu SH, Randolph JT, Danishefsky SJ, Livingston PO, Zhang SL (1995) J Am Chem Soc 117:7840

    Article  CAS  Google Scholar 

  63. Park TK, Kim IJ, Hu SH, Bilodeau MT, Randolph JT, Kwon O, Danishefsky SJ (1996) J Am Chem Soc 118:11488

    Article  CAS  Google Scholar 

  64. Allen JR, Allen JG, Zhang XF, Williams LJ, Zatorski A, Ragupathi G, Livingston PO, Danishefsky SJ (2000) Chem Eur J 6:1366

    Article  CAS  Google Scholar 

  65. Ragupathi G, Park TK, Zhang SL, Kim IJ, Graber L, Adluri S, Lloyd KO, Danishefsky SJ, Livingston PO (1997) Angew Chem Int Ed Engl 36:125

    Article  CAS  Google Scholar 

  66. Ragupathi G, Slovin SF, Adluri S, Sames D, Kim IJ, Kim HM, Spassova M, Bornmann WG, Lloyd KO, Scher HI, Livingston PO, Danishefsky SJ (1999) Angew Chem Int Ed Engl 38:563

    Article  CAS  Google Scholar 

  67. Slovin SF, Ragupathi G, Adluri S, Ungers G, Terry K, Kim S, Spassova M, Bornmann WG, Fazzari M, Dantis L, Olkiewicz K, Lloyd KO, Livingston PO, Danishefsky SJ, Scher HI (1999) Proc Natl Acad Sci USA 96:5710

    Article  CAS  Google Scholar 

  68. Wang ZG, Williams LJ, Zhang XF, Zatorski A, Kudryashov V, Ragupathi G, Spassova M, Bornmann W, Slovin SF, Scher HI, Livingston PO, Lloyd KO, Danishefsky SJ (2000) Proc Natl Acad Sci USA 97:2719

    Article  CAS  Google Scholar 

  69. Gilewski T, Ragupathi G, Bhuta S, Williams LJ, Musselli C, Zhang XF, Bornmann WG, Spassova M, Bencsath KP, Panageas KS, Chin J, Hudis CA, Norton L, Houghton AN, Livingston PO, Danishefsky SJ (2001) Proc Natl Acad Sci USA 98:3270

    Article  CAS  Google Scholar 

  70. Carlstedt I, Davies JR (1997) Biochem Soc Trans 25:214

    CAS  Google Scholar 

  71. Springer GF (1984) Science 224:1198

    Article  CAS  Google Scholar 

  72. Werther JL, Riveramacmurray S, Bruckner H, Tatematsu M, Itzkowitz SH (1994) Brit J Cancer 69:613

    Article  CAS  Google Scholar 

  73. Fung PY, Madej M, Koganty RR, Longenecker BM (1990) Cancer Res 50:4308

    CAS  Google Scholar 

  74. Livingston PO, Ragupathi G (1997) Cancer Immunol Immunother 45:10

    Article  CAS  Google Scholar 

  75. Zhang SL, Walberg LA, Ogata S, Itzkowitz SH, Koganty RR, Reddish M, Gandhi SS, Longenecker BM, Lloyd KO, Livingston PO (1995) Cancer Res 55:3364

    CAS  Google Scholar 

  76. Nakada H, Inoue M, Numata Y, Tanaka N, Funakoshi I, Fukui S, Mellors A, Yamashina I (1993) Proc Natl Acad Sci USA 90:2495

    Article  CAS  Google Scholar 

  77. Nakahara Y, Iijima H, Ogawa T (1994) Tetrahedron Lett 35:3321

    Article  CAS  Google Scholar 

  78. Liebe B, Kunz H (1994) Tetrahedron Lett 35:8777

    Article  CAS  Google Scholar 

  79. Meinjohanns E, Meldal M, Schleyer A, Paulsen H, Bock K (1996) J Chem Soc, Perkin Trans 1:985

    Article  Google Scholar 

  80. Mathieux N, Paulsen H, Meldal M, Bock K (1997) J Chem Soc, Perkin Trans 1:2359

    Article  Google Scholar 

  81. Chen XT, Sames D, Danishefsky SJ (1998) J Am Chem Soc 120:7760

    Article  CAS  Google Scholar 

  82. Kuduk SD, Schwarz JB, Chen XT, Glunz PW, Sames D, Ragupathi G, Livingston PO, Danishefsky SJ (1998) J Am Chem Soc 120:12474

    Article  CAS  Google Scholar 

  83. Kagan E, Ragupathi G, Yi SS, Reis CA, Gildersleeve J, Kahne D, Clausen H, Danishefsky SJ, Livingston PO (2005) Cancer Immunol Immunother 54:424

    Article  CAS  Google Scholar 

  84. Slovin SF, Ragupathi G, Musselli C, Olkiewicz K, Verbel D, Kuduk SD, Schwarz JB, Sames D, Danishefsky S, Livingston PO, Scher HI (2003) J Clin Oncol 21:4292

    Article  CAS  Google Scholar 

  85. Schwarz JB, Kuduk SD, Chen XT, Sames D, Glunz PW, Danishefsky SJ (1999) J Am Chem Soc 121:2662

    Article  CAS  Google Scholar 

  86. Sames D, Chen XT, Danishefsky SJ (1997) Nature 389:587

    Article  CAS  Google Scholar 

  87. Glunz PW, Hintermann S, Williams LJ, Schwarz JB, Kuduk SD, Kudryashov V, Lloyd KO, Danishefsky SJ (2000) J Am Chem Soc 122:7273

    Article  CAS  Google Scholar 

  88. Kudryashov V, Glunz PW, Williams LJ, Hintermann S, Danishefsky SJ, Lloyd KO (2001) Proc Natl Acad Sci USA 98:3264

    Article  CAS  Google Scholar 

  89. Ragupathi G, Cappello S, Yi SS, Canter D, Spassova M, Bornmann WG, Danishefsky SJ, Livingston PO (2002) Vaccine 20:1030

    Article  CAS  Google Scholar 

  90. Lee CJ, Lee LH, Koizumi K (2002) Infect Med 19:127

    Google Scholar 

  91. Lee CJ, Lee LH, Koizumi K (2002) Infect Med 19:179

    Google Scholar 

  92. Dagan R, Eskola J, Leclerc C, Leroy O (1998) Infect Immun 66:2093

    CAS  Google Scholar 

  93. Fattom A, Cho YH, Chu C, Fuller S, Fries L, Naso R (1999) Vaccine 17:126

    Article  CAS  Google Scholar 

  94. Herzenberg LA, Tokuhisa T, Herzenberg LA (1980) Nature 285:664

    Article  CAS  Google Scholar 

  95. Williams LJ, Harris CR, Glunz PW, Danishefsky SJ (2000) Tetrahedron Lett 41:9505

    Article  CAS  Google Scholar 

  96. Allen JR, Harris CR, Danishefsky SJ (2001) J Am Chem Soc 123:1890

    Article  CAS  Google Scholar 

  97. Ragupathi G, Coltart DM, Williams LJ, Koide F, Kagan E, Allen J, Harris C, Glunz PW, Livingston PO, Danishefsky SJ (2002) Proc Natl Acad Sci USA 99:13699

    Article  CAS  Google Scholar 

  98. Bessler WG, Cox M, Lex A, Suhr B, Wiesmuller KH, Jung G (1985) J Immunol 135:1900

    CAS  Google Scholar 

  99. Musselli C, Livingston PO, Ragupathi G (2001) J Cancer Res Clin Oncol 127:R20

    Article  CAS  Google Scholar 

  100. Biswas K, Coltart DM, Danishefsky SJ (2002) Tetrahedron Lett 43:6107

    Article  CAS  Google Scholar 

  101. Keding SJ, Atsushi E, Biswas K, Zatorski A, Coltart DM, Danishefsky SJ (2003) Tetrahedron Lett 44:3413

    Article  CAS  Google Scholar 

  102. Keding SJ, Endo A, Danishefsky SJ (2003) Tetrahedron 59:7023

    Article  CAS  Google Scholar 

  103. Keding SJ, Danishefsky SJ (2004) Proc Natl Acad Sci USA 101:11937

    Article  CAS  Google Scholar 

  104. Burton DR (1997) Proc Natl Acad Sci USA 94:10018

    Article  CAS  Google Scholar 

  105. Wei XP, Decker JM, Wang SY, Hui HX, Kappes JC, Wu XY, Salazar-Gonzalez JF, Salazar MG, Kilby JM, Saag MS, Komarova NL, Nowak MA, Hahn BH, Kwong PD, Shaw GM (2003) Nature 422:307

    Article  CAS  Google Scholar 

  106. Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, Wilson IA (2003) Science 300:2065

    Article  CAS  Google Scholar 

  107. Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Stanfield R, Wilson IA, Katinger H, Dwek RA, Rudd PM, Burton DR (2002) J Virol 76:7306

    Article  CAS  Google Scholar 

  108. Sanders RW, Venturi M, Schiffner L, Kalyanaraman R, Katinger H, Lloyd KO,Kwong PD, Moore JP (2002) J Virol 76:7293

    Article  CAS  Google Scholar 

  109. Dudkin VY, Orlova M, Geng X, Mandal M, Olson WC, Danishefsky SJ (2004) J Am Chem Soc 126:9560

    Article  CAS  Google Scholar 

  110. Dawson PE, Muir TW, Clark-Lewis I, Kent SBH (1994) Science 266:776

    Article  CAS  Google Scholar 

  111. Miller JS, Dudkin VY, Lyon GJ, Muir TW, Danishefsky SJ (2003) Angew Chem Int Ed Engl 42:431

    Article  CAS  Google Scholar 

  112. Dudkin VY, Miller JS, Danishefsky SJ (2004) J Am Chem Soc 126:736

    Article  CAS  Google Scholar 

  113. Dudkin VY, Miller JS, Danishefsky SJ (2003) Tetrahedron Lett 44:1791

    Article  CAS  Google Scholar 

  114. Zhang YM, Mallet JM, Sinaÿ P (1992) Carbohydr Res 236:73

    Article  CAS  Google Scholar 

  115. Likhosherstov LM, Novikova OS, Derevitskaja VA, Kochetkov NK (1986) Carbohydr Res 146:C1

    Article  CAS  Google Scholar 

  116. Cohen-Anisfeld ST, Lansbury PT (1993) J Am Chem Soc 115:10531

    Article  CAS  Google Scholar 

  117. Rich RL, Myszka DG (2000) Curr Opin Biotech 11:54

    Article  CAS  Google Scholar 

  118. Rich RL, Day YSN, Morton TA, Myszka DG (2001) Anal Biochem 296:197

    Article  CAS  Google Scholar 

  119. Trkola A, Dragic T, Arthos J, Binley JM, Olson WC, Allaway GP, ChengMayer C, Robinson J, Maddon PJ, Moore JP (1996) Nature 384:184

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The research reviewed in this manuscript was possible only through the dedication, enthusiasm, and creativity of those co-workers whose names are acknowledged on the publications cited from our laboratory. It is to these people, and to other members of the laboratory (who were constantly available for the extensive discussions that helped fashion this research) to whom the program is lastingly indebted. Financial support was largely provided by the National Institutes of Health, grants CA-103823 and CA-28824 (to S.J.D). We especially thank Mr. William H. Goodwin and Mrs. Alice Goodwin and the Commonwealth Cancer Foundation for Research for additional financial support. J.D.W. gratefully acknowledges the US Army Breast Cancer Research Foundation (DAMD17-03-1-0443) for a Postdoctoral Research Fellowship.

Author information

Authors and Affiliations

  1. Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, 10021, New York, NY, USA

    J. David Warren & Samuel J. Danishefsky

  2. Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, 10027, New York, NY, USA

    Samuel J. Danishefsky

  3. Global Discovery Chemistry, Novartis Institute for Biomedical Research, Inc., 100 Technology Square, 02139, Cambridge, MA, USA

    Xudong Geng

Authors
  1. J. David Warren
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xudong Geng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Samuel J. Danishefsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Samuel J. Danishefsky .

Editor information

Valentin Wittmann

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Warren, J.D., Geng, X., Danishefsky, S.J. (2006). Synthetic Glycopeptide-Based Vaccines. In: Wittmann, V. (eds) Glycopeptides and Glycoproteins. Topics in Current Chemistry, vol 267. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_031

Download citation

Publish with us

Policies and ethics

Search

Navigation