Abstract
To investigate the accuracy for absolute quantification of brain creatine (Cr) concentration using in vivo long echo time PRESS sequence performed with an external standard. Ten swine and an external standard phantom were investigated by 1.5T GE Signa scanner and the standard head coil. 1H-MRS data were acquired from the two VOI (2x2x2cm3) placed in swine brain and external standard solution by using PRESS sequence with TE = 135 mses, TR = 1500 msec, and 128 scan averages. In vivo Cr evaluation was made by LCModel. In vitro Cr concentration was analyzed by HPLC method. In the 1H-MRS group, the Cr concentration was 9.37±0.137 mmol/kg. In the HPLC group, the Cr concentration was 8.905±0.126 mmol/kg. Good agreement was obtained between in these two methods (P=0.491), which indicated that long echo time PRESS sequence with an external standard can accurately detect brain Cr concentration. The application of LCModel introduces more convenience for the MRS quantification.
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© 2006 Springer-Verlag Berlin Heidelberg
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Lin, Y. et al. (2006). Absolute Quantification of Brain Creatine Concentration Using Long Echo Time PRESS Sequence with an External Standard and LCModel: Verification with in Vitro HPLC Method. In: King, I., Wang, J., Chan, LW., Wang, D. (eds) Neural Information Processing. ICONIP 2006. Lecture Notes in Computer Science, vol 4232. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11893028_23
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DOI: https://doi.org/10.1007/11893028_23
Publisher Name: Springer, Berlin, Heidelberg
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