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Model Deconstruction of an Immunoprevention Vaccine

  • F. Pappalardo
  • P. -L. Lollini
  • S. Motta
  • E. Mastriani
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4222)

Abstract

We present a further step in developing an in silico model that simulates the immune system responses to tumor cells in vaccinated mice. Our study is based on our previous model that simulates the cancer – immune System competition activated by a tumor vaccine. In what follows, we show first results on effects of deconstructing the components of Triplex vaccine that are in very good agreement with in vivo results.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • F. Pappalardo
    • 1
    • 2
  • P. -L. Lollini
    • 3
  • S. Motta
    • 2
  • E. Mastriani
    • 2
  1. 1.Faculty of PharmacyUniversity of Catania 
  2. 2.Department of Mathematics and Computer ScienceUniversity of Catania 
  3. 3.Sezione di Cancerologia, Dipartimento di Patologia Sperimentale, and Centro Interdipartimentale di Ricerche sul Cancro ”Giorgio Prodi”University of Bologna 

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