Highly Accurate Segmentation of Brain Tissue and Subcortical Gray Matter from Newborn MRI

  • Neil I. Weisenfeld
  • Andrea U. J. Mewes
  • Simon K. Warfield
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4190)


The segmentation of newborn brain MRI is important for assessing and directing treatment options for premature infants at risk for developmental disorders, abnormalities, or even death. Segmentation of infant brain MRI is particularly challenging when compared with the segmentation of images acquired from older children and adults. We sought to develop a fully automated segmentation strategy and present here a Bayesian approach utilizing an atlas of priors derived from previous segmentations and a new scheme for automatically selecting and iteratively refining classifier training data using the STAPLE algorithm. Results have been validated by comparison to hand-drawn segmentations.


Training Point Cortical Gray Matter Accurate Segmentation Tissue Class Subcortical Gray Matter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Neil I. Weisenfeld
    • 1
    • 2
  • Andrea U. J. Mewes
    • 1
  • Simon K. Warfield
    • 1
  1. 1.Computational Radiology LaboratoryBrigham and Women’s and Children’s Hospitals, Harvard Medical SchoolBoston
  2. 2.Department of Cognitive and Neural SystemsBoston UniversityBoston

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