Did Germinal Centers Evolve Under Differential Effects of Diversity vs Affinity?
- 534 Downloads
The classical view on the process of mutation and affinity maturation that occurs in GCs assumes that their major role is to generate high affinity levels of serum Abs, as well as a dominant pool of high affinity memory B cells, through a very efficient selection process. Here we present a model that considers different types of structures where a mutation selection process occurs, with the aim at discussing the evolution of Germinal Center reactions. Based on the results of this model, we suggest that in addition to affinity maturation, the diversity generated during the GC reaction may have also been important in the evolution towards the presently observed highly organized structure of GC in higher vertebrates.
KeywordsDeleterious Mutation High Vertebrate Lower Vertebrate Primary Immune Response Germinal Center Reaction
Unable to display preview. Download preview PDF.
- 1.Janeway, C., Travers, P., Walport, M., Shlomchik, M.: Immunobiology: the immune system in health and disease, 6th edn. Garland Science, New York (2004)Google Scholar
- 7.Gordo, I., Charlesworth, B.: On the speed of Muller’s ratchet. Genetics 156, 2137–2140 (2000)Google Scholar
- 8.Bachtrog, D., Gordo, I.: Adaptive evolution of asexual populations under Muller’s ratchet. Evolution Int. J. Org. Evolution 58, 1403–1413 (2004)Google Scholar
- 10.Charlesworth, B., Morgan, M.T., Charlesworth, D.: The effect of deleterious mutations on neutral molecular variation. Genetics 134, 1289–1303 (1993)Google Scholar