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Optical Waveguide-Based Cellular Assays

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Label-Free Monitoring of Cells in vitro

Part of the book series: Bioanalytical Reviews ((BIOREV,volume 2))

Abstract

Optical waveguides have been widely used to develop a range of biosensing platforms. Among them, resonant waveguide grating (RWG) has found broad applications in monitoring cell phenotypic responses in native cells mostly due to its adoption to microtiter plates, the de facto footprint for drug discovery. This chapter first reviews RWG biosensor configurations and reader systems, followed by a discussion about how to apply them to facilitate drug discovery, elucidate receptor biology, and perform single-cell analysis.

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Authors and Affiliations

  1. Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, NY, USA

    Y. Fang

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Correspondence to Y. Fang .

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  1. Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Regensburg, Germany

    Joachim Wegener

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Fang, Y. (2018). Optical Waveguide-Based Cellular Assays. In: Wegener, J. (eds) Label-Free Monitoring of Cells in vitro. Bioanalytical Reviews, vol 2. Springer, Cham. https://doi.org/10.1007/11663_2018_3

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